A noticeable phenomenon: Thiol terminal PEG enhances the immunogenicity of PEGylated emulsions injected intravenously or subcutaneously into rats

Yamaoka, 1994, Distribution and tissue uptake of poly (ethylene glycol) with different molecular weights after intravenous administration to mice, J. Pharm. Sci., 83, 601, 10.1002/jps.2600830432 Gref, 1995, The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres, Adv. Drug Deliv. Rev., 16, 215, 10.1016/0169-409X(95)00026-4 Abuchowski, 1979, Preparation and properties of polyethylene glycol-trypsin adducts, Biochim. Biophys. Acta: Protein Struct., 578, 41, 10.1016/0005-2795(79)90110-7 Allen, 1991, Liposomes containing synthetic lipid derivatives of poly (ethylene glycol) show prolonged circulation half-lives in vivo, BBA-Biomembranes, 1066, 29, 10.1016/0005-2736(91)90246-5 Li, 2001, PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats, J. Control. Release, 71, 203, 10.1016/S0168-3659(01)00218-8 Manson, 2011, Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media, Gold Bull., 44, 99, 10.1007/s13404-011-0015-8 Dams, 2000, Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes, J. Pharmacol. Exp. Ther., 292, 1071 Laverman, 2000, Preclinical and clinical evidence for disappearance of long-circulating characteristics of polyethylene glycol liposomes at low lipid dose, J. Pharmacol. Exp. Ther., 293, 996 Ishida, 2002, The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study, Cell. Mol. Biol. Lett., 7, 286 Ishihara, 2009, Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles, Pharm. Res., 26, 2270, 10.1007/s11095-009-9943-x Lu, 2007, Brain delivery property and accelerated blood clearance of cationic albumin conjugated pegylated nanoparticle, J. Control. Release, 118, 38, 10.1016/j.jconrel.2006.11.015 Kaminskas, 2011, Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance, J. Pharm. Sci., 100, 5069, 10.1002/jps.22682 Ishida, 2006, Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes, J. Control. Release, 115, 243, 10.1016/j.jconrel.2006.08.001 Ishida, 2006, Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes, J. Control. Release, 112, 15, 10.1016/j.jconrel.2006.01.005 Ishida, 2004, Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice, J. Control. Release, 95, 403, 10.1016/j.jconrel.2003.12.011 Wang, 2005, Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats, J. Control. Release, 104, 91, 10.1016/j.jconrel.2005.01.008 Yan, 2012, LyP-1-conjugated PEGylated liposomes: a carrier system for targeted therapy of lymphatic metastatic tumor, J. Control. Release, 157, 118, 10.1016/j.jconrel.2011.07.034 Hood, 2011, Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis, Cancer Res., 71, 3792, 10.1158/0008-5472.CAN-10-4455 Ichihara, 2010, Anti-PEG IgM response against PEGylated liposomes in mice and rats, Pharmaceutics, 3, 1, 10.3390/pharmaceutics3010001 Laverman, 2001, Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection, J. Pharmacol. Exp. Ther., 298, 607 Oussoren, 1997, Lymphatic uptake and biodistribution of liposomes after subcutaneous injection: II. Influence of liposomal size, lipid composition and lipid dose, BBA-Biomembranes, 1328, 261, 10.1016/S0005-2736(97)00122-3 Harrell, 2008, Lymph node mapping in the mouse, J. Immunol. Methods, 332, 170, 10.1016/j.jim.2007.11.012 Zhang, 2004, Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter, Hum. Gene Ther., 15, 339, 10.1089/104303404322959498 Ripollés, 2003, The role of ultrasound in the diagnosis, management and evolutive prognosis of acute left-sided colonic diverticulitis: a review of 208 patients, Eur. Radiol., 13, 2587, 10.1007/s00330-003-1861-4 Zhao, 2012, Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles, Int. J. Nanomed., 7, 2891 Shiraishi, 2012, Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon, J. Control. Release, 165, 183, 10.1016/j.jconrel.2012.11.016 Koide, 2010, T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes, Int. J. Pharm., 392, 218, 10.1016/j.ijpharm.2010.03.022 Ishida, 2007, PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner, J. Control. Release, 122, 349, 10.1016/j.jconrel.2007.05.015 Humphrey, 2005, Tolerogenic or immunogenic activity of hapten-conjugated polysaccharides correlated with cellular localization, Eur. J. Immunol., 11, 212, 10.1002/eji.1830110310 Mond, 1995, T cell independent antigens, Curr. Opin. Immunol., 7, 349, 10.1016/0952-7915(95)80109-X Aggarwal, 2009, Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy, Adv. Drug Deliv. Rev., 61, 428, 10.1016/j.addr.2009.03.009 Alexis, 2008, Factors affecting the clearance and biodistribution of polymeric nanoparticles, Mol. Pharm., 5, 505, 10.1021/mp800051m Woodle, 1992, Sterically stabilized liposomes, Biochim. Biophys. Acta, 1113, 171, 10.1016/0304-4157(92)90038-C Ishida, 2002, Liposome clearance, Biosci. Rep., 22, 197, 10.1023/A:1020134521778 Law, 1995 Montdargent, 1993, Regulation by sulphonate groups of complement activation induced by hydroxymethyl groups on polystyrene surfaces, Biomaterials, 14, 203, 10.1016/0142-9612(93)90024-V Sahu, 2002, Structure and biology of complement protein C3, a connecting link between innate and acquired immunity, Immunol. Rev., 180, 35, 10.1034/j.1600-065X.2001.1800103.x Torchilinl, 1994, Why do polyethylene glycol-coated liposomes circulate so long?: Molecular mechanism of liposome steric protection with polyethylene glycol: role of polymer chain flexibility, J. Liposome Res., 4, 725, 10.3109/08982109409037068 Salvador-Morales, 2009, Immunocompatibility properties of lipid–polymer hybrid nanoparticles with heterogeneous surface functional groups, Biomaterials, 30, 2231, 10.1016/j.biomaterials.2009.01.005 Toda, 2008, Complement activation on surfaces carrying amino groups, Biomaterials, 29, 407, 10.1016/j.biomaterials.2007.10.005 Ishida, 2005, Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes, J. Control. Release, 105, 305, 10.1016/j.jconrel.2005.04.003 Bertrand, 2012, The journey of a drug-carrier in the body: an anatomo-physiological perspective, J. Control. Release, 161, 152, 10.1016/j.jconrel.2011.09.098 Hawley, 1995, Targeting of colloids to lymph nodes: influence of lymphatic physiology and colloidal characteristics, Adv. Drug Deliv. Rev., 17, 129, 10.1016/0169-409X(95)00045-9 Pal, 2011, The role of the lymphatic system in vaccine trafficking and immune response, Adv. Drug Deliv. Rev., 63, 909, 10.1016/j.addr.2011.05.018 O’Hagan, 1992, Particulates and lymphatic drug delivery, 279 Goodman, 1977, Nonspecific activation of murine lymphocytes. I. Proliferation and polyclonal activation induced by 2-mercaptoethanol and alpha-thioglycerol, J. Exp. Med., 145, 473, 10.1084/jem.145.3.473 Goodman, 1978, Nonspecific activation of murine lymphocytes. IV. Proliferation of a distinct, late maturing lymphocyte subpopulation induced by 2-mercaptoethanol. [Gamma radiation], J. Immunol. (United States), 121 Ohmori, 1981, Activation of murine lymphocytes by 2-mercaptoethanol and related thiol compounds and its mechanism. I. Relationship between mitogenic activities and augmenting effects on antibody synthesis in vitro, Immunopharmacology, 3, 333, 10.1016/0162-3109(81)90026-6 Zmuda, 1983, Changes in intracellular glutathione levels in stimulated and unstimulated lymphocytes in the presence of 2-mercaptoethanol or cysteine, J. Immunol., 130, 362, 10.4049/jimmunol.130.1.362 Ishii, 1981, Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro. Role of the mixed disulfide of 2-mercaptoethanol and cysteine, J. Biol. Chem., 256, 12387, 10.1016/S0021-9258(18)43284-X Hoffeld, 1981, Agents which block membrane lipid peroxidation enhance mouse spleen cell immune activities in vitro: relationship to the enhancing activity of 2-mercaptoethanol, Eur. J. Immunol., 11, 371, 10.1002/eji.1830110505 Gray, 2002, A role for antigen in the maintenance of immunological memory, Nat. Rev. Immunol., 2, 60, 10.1038/nri706