A new method for quantifying causative and diagnostic markers of methylenecyclopropylglycine poisoning

Scott, 1916, On the vomiting sickness of Jamaica, Ann. Trop. Med. Parasitol., 10, 1, 10.1080/00034983.1916.11684104 Antoine, 2017, Assessment of the potential health risks associated with the aluminium, arsenic, cadmium and lead content in selected fruits and vegetables grown in Jamaica, Toxicol. Rep., 4, 181, 10.1016/j.toxrep.2017.03.006 Paireau, 2012, Litchi-associated acute encephalitis in children, Northern Vietnam, 2004-2009, Emerg. Infect. Dis., 18, 1817, 10.3201/eid1811.111761 John, 2014, Acute encephalitis syndrome in children in Muzaffarpur: hypothesis of toxic origin, Curr. Sci., 106, 1184 Shah, 2014, Recurrent outbreaks of hypoglycaemic encephalopathy in Muzaffarpur, Bihar, Curr. Sci., 107, 570 Das, 2015, Litchi fruit contains methylenecyclopropylglycine, Curr. Sci., 109, 2195 Shrivastava, 2015, 49 Shrivastava, 2017, Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study, Lancet Glob. Health, 5, e458, 10.1016/S2214-109X(17)30035-9 Pulla, 2015, A child-killing toxin emerges from shadows, Science, 348, 15, 10.1126/science.348.6230.15 Phan, 2018, Hypoglycemic toxins and enteroviruses as causes of outbreaks of acute encephalitis-like syndrome in children, Bac Giang Province, Northern Vietnam, Emerg. Infect. Dis., 24, 1435, 10.3201/eid2408.171004 Westermann, 2008, Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy, Neuromuscul. Disord., 18, 355, 10.1016/j.nmd.2008.02.007 Sponseller, 2012, Equine multiple acyl-CoA dehydrogenase deficiency (MADD) associated with seasonal pasture myopathy in the midwestern United States, J. Vet. Intern. Med., 26, 1012, 10.1111/j.1939-1676.2012.00957.x Valberg, 2013, Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree, Equine Vet. J., 45, 419, 10.1111/j.2042-3306.2012.00684.x Votion, 2014, Identification of methylenecyclopropyl acetic acid in serum of European horses with atypical myopathy, Equine Vet. J., 46, 146, 10.1111/evj.12117 Gray, 1962, Alpha-(methylenecyclopropyl)glycine from Litchi seeds, Biochem. J., 82, 385, 10.1042/bj0820385 Eloff, 1970, The isolation of hypoglycin A and related compounds from Billia hippocastanum, Phytochemistry, 9, 2423, 10.1016/S0031-9422(00)85756-8 Fowden, 1972, Nitrogenous constituents of Billia hippocastanum and Acer pseudoplatanus, Phytochemistry, 11, 3521, 10.1016/S0031-9422(00)89850-7 Minakata, 1985, Antimutagenic unusual amino acids from plants, Experientia, 41, 1622, 10.1007/BF01964840 Melde, 1991, Metabolic consequences of methylenecyclopropylglycine poisoning in rats, Biochem. J., 274, 395, 10.1042/bj2740395 Fowden, 1973, Cyclopropyl amino acids of the genus Acer: distribution and biosynthesis, Phytochemistry, 12, 1677, 10.1016/0031-9422(73)80387-5 Isenberg, 2015, Quantification of metabolites for assessing human exposure to soapberry toxins hypoglycin A and methylenecyclopropylglycine, Chem. Res. Toxicol., 28, 1753, 10.1021/acs.chemrestox.5b00205 Isenberg, 2016, Quantification of toxins in soapberry (Sapindaceae) arils: hypoglycin A and methylenecyclopropylglycine, J. Agric. Food Chem., 64, 5607, 10.1021/acs.jafc.6b02478 Sander, 2017, Quantification of methylenecyclopropyl compounds and acyl conjugates by UPLC-MS/MS in the study of the biochemical effects of the ingestion of canned ackee (Blighiasapida) and lychee (Litchi chinensis), J. Agric. Food Chem., 65, 2603, 10.1021/acs.jafc.7b00224 Poirier, 2006, Peroxisomal beta-oxidation-a metabolic pathway with multiple functions, Biochim. Biophys. Acta, 1763, 1413, 10.1016/j.bbamcr.2006.08.034 Tanaka, 1971, Hypoglycin A: a specific inhibitor of isovaleryl CoA dehydrogenase, Proc. Natl. Acad. Sci. U. S. A., 68, 20, 10.1073/pnas.68.1.20 Kean, 1976, Selective inhibition of acyl-CoA dehydrogenases by a metabolite of hypoglycin, Biochim. Biophys. Acta, 422, 8, 10.1016/0005-2744(76)90003-6 Li, 1999, The Toxicity of methylenecyclopropylglycine: studies of the inhibitory effects of (methylenecyclopropyl)formyl-CoA on enzymes involved in fatty acid metabolism and the molecular basis of its inactivation of enoyl-CoA hydratases, J. Am. Chem. Soc., 121, 9034, 10.1021/ja991908w Agnihotri, 2002, A revised mechanism for the inactivation of bovine liver enoyl-CoA hydratase by (methylenecyclopropyl) formyl-CoA based on unexpected results with the C114A mutant, Biochemistry, 41, 1843, 10.1021/bi0119363 Sander, 2016, Rapid diagnosis of hypoglycin A intoxication in atypical myopathy of horses, J. Vet. Diagn. Invest., 28, 98, 10.1177/1040638715624736 Sander, 2016, Quantification of hypoglycin A as butyl ester, J. Chromatogr. B, 1029, 169, 10.1016/j.jchromb.2016.07.005 van Eeckhaut, 2009, Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects, J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 877, 2198, 10.1016/j.jchromb.2009.01.003 Isenberg, 2015, Quantification of metabolites for assessing human exposure to soapberry toxins hypoglycin A and methylenecyclopropylglycine, Chem. Res. Toxicol., 28, 1753, 10.1021/acs.chemrestox.5b00205 Wu, 2008, Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation, Org. Lett., 10, 3355, 10.1021/ol801267e