A new insight on elderberry anthocyanins bioactivity: Modulation of mitochondrial redox chain functionality and cell redox state

Andoni, 2016, Theoretical determination of the redox electrode potential of cyanidin, Journal of the Serbian Chemical Society, 81, 177, 10.2298/JSC150715075A Andres-Lacueva, 2005, Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory, Nutritional Neuroscience, 8, 111, 10.1080/10284150500078117 Asseburg, 2016, Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice, Neuromolecular Medicine, 18, 378, 10.1007/s12017-016-8428-4 Bernardo, 2018, In vitro multimodal–effect of Trichilia catigua A. Juss. (Meliaceae) bark aqueous extract in CNS targets, Journal of Ethnopharmacology, 211, 247, 10.1016/j.jep.2017.09.039 Borkowski, 2005, Radical scavenging capacity of wine anthocyanins is strongly pH-dependent, Journal of Agricultural and Food Chemistry, 53, 5526, 10.1021/jf0478556 Carballo-Carbajal, 2019, Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis, Nature Communications, 10, 973, 10.1038/s41467-019-08858-y Chan, 2011, Optimization and validation of a cell-based tyrosinase assay for screening of tyrosinase inhibitors, Journal of the University of Malaya Medical Centre, 14, 1 Chen, 2011, Myricetin affords protection against peroxynitrite-mediated DNA damage and hydroxyl radical formation, Food and Chemical Toxicology, 49, 2439, 10.1016/j.fct.2011.06.066 Chen, 2012, Neuroprotective effect of raspberry extract by inhibiting peroxynitrite-induced DNA damage and hydroxyl radical formation, Food Research International, 49, 22, 10.1016/j.foodres.2012.07.021 Chen, 2013, Myricitrin protects against peroxynitrite-mediated DNA damage and cytotoxicity in astrocytes, Food Chemistry, 141, 927, 10.1016/j.foodchem.2013.04.033 Chen, 2015, A new function of Chinese bayberry extract: Protection against oxidative DNA damage, Food Science and Technology, 60, 1200 Chuang, 2014, Dietary Sutherlandia and elderberry mitigate cerebral ischemia-induced neuronal damage and attenuate p47phox and phospho-ERK1/2 expression in microglial cells, ASN Neuro, 6, 10.1177/1759091414554946 Duymus, 2014, In vitro antioxidant properties and anthocyanin compositions of elderberry extracts, Food Chemistry, 15, 112, 10.1016/j.foodchem.2014.01.028 Gellerich, 2002, Mitochondrial respiratory rates and activities of respiratory chain complexes correlate linearly with heteroplasmy of deleted mtDNA without threshold and independently of deletion size, Biochimica et Biophysica Acta, 1556, 41, 10.1016/S0005-2728(02)00305-5 Green, 2011, Mitochondria and the autophagy-inflammation-cell death axis in organismal aging, Science, 333, 1109, 10.1126/science.1201940 Hoyos-Arbeláez, 2017, Electrochemical methods as a tool for determining the antioxidant capacity of food and beverages: A review, Food Chemistry, 221, 1371, 10.1016/j.foodchem.2016.11.017 Janeiro, 2007, Redox behavior of anthocyanins present in Vitis vinifera L, Electroanalysis, 19, 1779, 10.1002/elan.200703941 Jones, 2010, Redox sensing: Orthogonal control in cell cycle and apoptosis signalling, Journal of Internal Medicine, 268, 432, 10.1111/j.1365-2796.2010.02268.x Johnson, 2015, Impact of frozen storage on the anthocyanin and polyphenol contents of American elderberry fruit juice, Journal of Agricultural and Food Chemistry, 63, 5653, 10.1021/acs.jafc.5b01702 Kelsey, 2011, Neuroprotective effects of anthocyanins on apoptosis induced by mitochondrial oxidative stress, Nutritional Neuroscience, 14, 249, 10.1179/1476830511Y.0000000020 Lacroix, 2018, A computationally driven analysis of the polyphenol–protein interactome, Scientific Reports, 8, 2232, 10.1038/s41598-018-20625-5 Lane, 2011, Mitonuclear match: Optimizing fitness and fertility over generations drives ageing within generations, Bioessays, 33, 860, 10.1002/bies.201100051 Lee, 2007, Anthocyanins and other polyphenolics in American elderberry (Sambucus canadensis) and European elderberry (S. nigra) cultivars, Journal of the Science of Food and Agriculture, 87, 2665, 10.1002/jsfa.3029 Leung, 2007, Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity, Neuropharmacology, 52, 827, 10.1016/j.neuropharm.2006.10.001 Mendes, 2018, Beneficial effects of white wine polyphenols-enriched diet on Alzheimer’s disease–like pathology, Journal of Nutritional Biochemistry, 55, 65, 10.1016/j.jnutbio.2018.02.001 Mlynarczyk, 2018, Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry, Journal of Functional Foods, 40, 377, 10.1016/j.jff.2017.11.025 Monteiro-Cardoso, 2015, Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer’s disease, Journal of Alzheimers Disease, 43, 1375, 10.3233/JAD-141002 Na, 2008, Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG, Food and Chemical Toxicology, 46, 1271, 10.1016/j.fct.2007.10.006 Olejnik, 2016, Gastrointestinal digested Sambucus nigra L. fruit extract protects in vitro cultured human colon cells against oxidative stress, Food Chemistry, 197, 648, 10.1016/j.foodchem.2015.11.017 Parrado-Fernández, 2016, Anthocyanins protect from complex I inhibition and APPswe mutation through modulation of the mitochondrial fission/fusion pathways, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862, 2110, 10.1016/j.bbadis.2016.08.002 Porter, 2017, A review of the antiviral properties of black elder (Sambucus nigra L.) products, Phytotherapy Research, 31, 533, 10.1002/ptr.5782 Rebelo, 2014, Phenolic profile of Douro wines and evaluation of their NO scavenging capacity in LPS-stimulated RAW 264.7 macrophages, Food Chemistry, 163, 16, 10.1016/j.foodchem.2014.04.070 Rieger, 2008, Influence of altitudinal variation on the content of phenolic compounds in wild populations of Calluna vulgaris, Sambucus nigra, and Vaccinium myrtillus, Journal of Agricultural and Food Chemistry, 56, 9080, 10.1021/jf801104e Salvador, 2018, Sambucus nigra L. berries and flowers health benefits, from lab testing to human consumption, 1 Santos, 2014, Interaction of fullerene nanoparticles with biomembranes, from the partition in lipid membranes to effects on mitochondrial bioenergetics, Toxicological Sciences, 138, 117, 10.1093/toxsci/kft327 Schneider, 2011, Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress, Free Radical Biology and Medicine, 51, 2007, 10.1016/j.freeradbiomed.2011.08.030 Simonyi, 2015, Inhibition of microglial activation by elderberry extracts and its phenolic components, Life Science, 128, 30, 10.1016/j.lfs.2015.01.037 Skemiene, 2015, Anthocyanins as substrates for mitochondrial complex I – Protective effect against heart ischemic injury, FEBS Journal, 282, 963, 10.1111/febs.13195 Spagnuolo, 2016, Neuroprotective role of natural polyphenols, Current Topics in Medicinal Chemistry, 16, 1943, 10.2174/1568026616666160204122449 Strathearn, 2014, Neuroprotective effects of anthocyanin-and proanthocyanidins rich extracts in cellular models of Parkinson’s disease, Brain Research, 25, 60, 10.1016/j.brainres.2014.01.047 Upadhyay, 2015, Role of polyphenols and other phytochemicals on molecular signaling, Oxidative Medicine and Cellular Longevity, 504253 Veberic, 2009, European elderberry (Sambucus nigra L.) rich in sugars, organic acids, anthocyanins and selected polyphenols, Food Chemistry, 114, 511, 10.1016/j.foodchem.2008.09.080 Veberic, 2014, Changes in the contents of anthocyanins and other compounds in blackberry fruits due to freezing and long-term frozen storage, Journal of Agricultural and Food Chemistry, 62, 6926, 10.1021/jf405143w Videira, 2018, Toxicity and structure-activity relationship (SAR) of α, β-dehydroamino acids against human cancer cell lines, Toxicology in Vitro, 47, 26, 10.1016/j.tiv.2017.10.027 Winklhofer, 2010, Mitochondrial dysfunction in Parkinson's disease, Biochimica et Biophysica Acta, 1802, 29, 10.1016/j.bbadis.2009.08.013 Wu, 2004, Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity, Journal of Agricultural and Food Chemistry, 52, 7846, 10.1021/jf0486850 Xicoy, 2017, The SH-SY5Y cell line in Parkinson’s disease research: A systematic review, Molecular Neurodegeneration, 12, 10, 10.1186/s13024-017-0149-0 Youdim, 2000, Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress, Free Radical Biology and Medicine, 29, 51, 10.1016/S0891-5849(00)00329-4 Yuyun, 2012, Effects of low concentrations of rotenone upon mitohormesis in SH-SY5Y cells, Dose Response, 10, 270