A new coronavirus associated with human respiratory disease in China

Nature - Tập 579 Số 7798 - Trang 265-269 - 2020
Fan Wu1, Suisheng Zhao2, Bin Yu3, Yan-Mei Chen1, Wen Wang4, Zhenyuan Song1, Yi Hu2, Tong Zhao2, Jian Tian3, Ping Yuan1, Ming-Li Yuan2, Yu Ling Zhang1, Fa-Hui Dai1, Yi Liu1, Qi Min Wang1, Jiao Zheng1, Lin Xu1, Edward C. Holmes5, Yong Zhen Zhang4
1Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
2Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
3Wuhan Center for Disease Control and Prevention, Wuhan, China
4Department of Zoonosis, National Institute for Communicable Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China
5Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia

Tóm tắt

Abstract

Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health1–3. Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. As of 25 January 2020, at least 1,975 cases had been reported since the first patient was hospitalized on 12 December 2019. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan. Here we study a single patient who was a worker at the market and who was admitted to the Central Hospital of Wuhan on 26 December 2019 while experiencing a severe respiratory syndrome that included fever, dizziness and a cough. Metagenomic RNA sequencing4 of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here ‘WH-Human 1’ coronavirus (and has also been referred to as ‘2019-nCoV’). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that the virus was most closely related (89.1% nucleotide similarity) to a group of SARS-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) that had previously been found in bats in China5. This outbreak highlights the ongoing ability of viral spill-over from animals to cause severe disease in humans.

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Nature

Tập 579 Số 7798

265-269

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