A new {Ni5} cluster-based compound: photocatalytic property and treatment activity on acute myocardial infarction by regulating the expression of lncRNA

Springer Science and Business Media LLC - Tập 19 - Trang 393-400 - 2021
Yuanman Sun1, Yu Sun2, Zhongyao Dong3, Bing Wu1, Baorui Cao2, Hongmei Jiang1
1Department of Geriatrics, Zaozhuang Mental Health Center, Zaozhuang, China
2Sleep Division, Zaozhuang Mental Health Center, Zaozhuang, China
3Community Healthcare Center, Zaozhuang Mental Health Center, Zaozhuang, China

Tóm tắt

By the self-assemble reaction of tri(2-carboxyethyl)isocyanurate (H3tci) and Ni(NO3)2·6H2O under solvothermal conditions, a new Ni(II) compound has been successfully prepared and structurally characterized, and its chemical formula is [Ni5(μ3-OH)2(NO3)2(tci)2(DMA)4]n (1). The optical band gap (Eg) of 1 is 3.4 eV, which makes it exhibit photocatalytic effect for the MB degradation under the irradiation of ultraviolet light with 88.41% MB successful removal within 120 min. Its application values on the acute ischemic myocardial infarction were assessed and its detailed mechanism was also investigated. Firstly, the inflammatory cytokines levels were released into the plasma during acute myocardial infarction after treated with the ELISA detection kit. Moreover, the real-time RT-PCR assay was carried out for the measurement of the lncRNA-ZFAS1 relative expression levels. Above all, we can get the conclusion that the compound possesses excellent application value on the ischemic myocardial infarction treatment through regulating expression level of lncRNA-ZFAS1.

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