A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3β-Nrf2 signaling pathway

Amin, 2017, Vanillic acid attenuates Aβ 1-42-induced oxidative stress and cognitive impairment in mice, Sci. Rep., 7, 40753, 10.1038/srep40753

Antunes, 2012, The novel object recognition memory: neurobiology, test procedure, and its modifications, Cogn. Process., 13, 93, 10.1007/s10339-011-0430-z

Burke, 2017, Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms, J. Neurochem., 142, 162, 10.1111/jnc.14077

Calderon-Montano, 2011, A review on the dietary flavonoid kaempferol, 11, 298

Chen, 2012, Hyper-phosphorylation of GSK-3β: possible roles in chlorpyrifos-induced behavioral alterations in animal model of depression, Neurosci. Lett., 528, 148, 10.1016/j.neulet.2012.08.084

Chowdhury, 2013, Detection of the residues of nineteen pesticides in fresh vegetable samples using gas chromatography–mass spectrometry, Food Control, 34, 457, 10.1016/j.foodcont.2013.05.006

Coyle, 1993, Oxidative stress, glutamate, and neurodegenerative disorders, Science, 262, 689, 10.1126/science.7901908

Demir, 2011, Subacute chlorpyrifos-induced oxidative stress in rat erythrocytes and the protective effects of catechin and quercetin, Pestic. Biochem. Physiol., 99, 77, 10.1016/j.pestbp.2010.11.002

Eftekharzadeh, 2010, Stabilization of transcription factor Nrf2 by tBHQ prevents oxidative stress-induced amyloid β formation in NT2N neurons, Biochimie, 92, 245, 10.1016/j.biochi.2009.12.001

Filomeni, 2012, Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease, Neurobiol. Aging, 33, 767, 10.1016/j.neurobiolaging.2010.05.021

Gameiro, 2017, Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease, Sci. Rep., 7, 10.1038/srep45701

Hernandez, 2015, Repeated exposure to chlorpyrifos leads to prolonged impairments of axonal transport in the living rodent brain, Neurotoxicology, 47, 17, 10.1016/j.neuro.2015.01.002

Hidaka, 2011, Inhibitory effects of valproate on impairment of Y-maze alternation behavior induced by repeated electroconvulsive seizures and c-Fos protein levels in rat brains, Acta Med. Okayama, 65, 269

Hung, 2018, Nuclear factor erythroid-2-related factor regulates LRWD1 expression and cellular adaptation to oxidative stress in human embryonal carcinoma cells, Biochimie, 148, 99, 10.1016/j.biochi.2018.03.001

Hybertson, 2011, Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation, Mol. Asp. Med., 32, 234, 10.1016/j.mam.2011.10.006

Jett, 2006, Noncholinesterase mechanisms of central and peripheral neurotoxicity: muscarinic receptors and other targets, 233

Karanth, 2006, Effects of acute chlorpyrifos exposure on in vivo acetylcholine accumulation in rat striatum, Toxicol. Appl. Pharmacol., 216, 150, 10.1016/j.taap.2006.04.006

Kensler, 2007, Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway, Annu. Rev. Pharmacol. Toxicol., 47, 89, 10.1146/annurev.pharmtox.46.120604.141046

Ki, 2013, JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis, Toxicol. Lett., 218, 235, 10.1016/j.toxlet.2013.02.003

Kim, 2010, Protective effects of kaempferol (3, 4′, 5, 7-tetrahydroxyflavone) against amyloid beta peptide (Aβ)-induced neurotoxicity in ICR mice, Biosci. Biotechnol. Biochem., 74, 397, 10.1271/bbb.90585

Kogai, 2008, Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells, J. Endocrinol., 199, 243, 10.1677/JOE-08-0333

Lagoa, 2009, Kaempferol protects against rat striatal degeneration induced by 3-nitropropionic acid, J. Neurochem., 111, 473, 10.1111/j.1471-4159.2009.06331.x

Lee, 2007, Glycogen synthase kinase-3β activity plays very important roles in determining the fate of oxidative stress-inflicted neuronal cells, Brain Res., 1129, 89, 10.1016/j.brainres.2006.10.055

Leung, 2007, Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes, Food Chem. Toxicol., 45, 2005, 10.1016/j.fct.2007.04.023

Li, 2011, Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse model of Parkinson's disease, Biol. Pharm. Bull., 34, 1291, 10.1248/bpb.34.1291

Livak, 2001, 25, 402

Llorens-Marítin, 2014, GSK-3β, a pivotal kinase in Alzheimer disease, Front. Mol. Neurosci., 7, 46

López-Granero, 2013, Chronic dietary exposure to chlorpyrifos causes behavioral impairments, low activity of brain membrane-bound acetylcholinesterase, and increased brain acetylcholinesterase-R mRNA, Toxicology, 308, 41, 10.1016/j.tox.2013.03.009

López-Granero, 2014, Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression, Neurotoxicology, 40, 57, 10.1016/j.neuro.2013.11.004

Mahat, 2010, Modulation of the cyclooxygenase pathway via inhibition of nitric oxide production contributes to the anti-inflammatory activity of kaempferol, Eur. J. Pharmacol., 642, 169, 10.1016/j.ejphar.2010.05.062

Mansour, 2009, Lipid peroxidation and oxidative stress in rat erythrocytes induced by chlorpyrifos and the protective effect of zinc, Pestic. Biochem. Physiol., 93, 34, 10.1016/j.pestbp.2008.09.004

Middlemore-Risher, 2010, Repeated exposures to low-level chlorpyrifos results in impairments in sustained attention and increased impulsivity in rats, Neurotoxicol. Teratol., 32, 415, 10.1016/j.ntt.2010.03.008

Middlemore-Risher, 2011, Effects of chlorpyrifos and chlorpyrifos-oxon on the dynamics and movement of mitochondria in rat cortical neurons, J. Pharmacol. Exp. Ther., 339, 341, 10.1124/jpet.111.184762

Nirmala, 2011, Effect of kaempferol on lipid peroxidation and antioxidant status in 1, 2-dimethyl hydrazine induced colorectal carcinoma in rats, Eur. J. Pharmacol., 654, 75, 10.1016/j.ejphar.2010.11.034

Omar, 2016, Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: Targeting MAPKs and apoptosis, PLoS ONE, 11, 10.1371/journal.pone.0151649

Phiel, 2003, GSK-3α regulates production of Alzheimer's disease amyloid-β peptides, Nature, 423, 435, 10.1038/nature01640

Plattner, 2006, The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation, J. Biol. Chem., 281, 25457, 10.1074/jbc.M603469200

Ray, 2001, The potential for toxic effects of chronic, low-dose exposure to organophosphates, Toxicol. Lett., 120, 343, 10.1016/S0378-4274(01)00266-1

Rojo, 2008, Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal celldeath, Mol. Cell. Neurosci., 39, 125, 10.1016/j.mcn.2008.06.007

Ruiz-Muñoz, 2011, Cognitive and histological disturbances after chlorpyrifos exposure and chronic Aβ(1-42) infusions in Wistar rats, Neurotoxicology, 32, 836, 10.1016/j.neuro.2011.05.014

Rush, 2010, Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture, Neuroscience, 166, 899, 10.1016/j.neuroscience.2010.01.025

Sklepkiewicz, 2011, Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension, PLoS ONE, 6, 10.1371/journal.pone.0018883

Slotkin, 2004, Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates, Toxicol. Appl. Pharmacol., 198, 132, 10.1016/j.taap.2003.06.001

Slotkin, 2005, Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination, Dev. Brain Res., 157, 172, 10.1016/j.devbrainres.2005.04.001

Tian, 2015, The effect of HMGB1 on sub-toxic chlorpyrifos exposure-induced neuroinflammation in amygdala of neonatal rats, Toxicology, 338, 95, 10.1016/j.tox.2015.10.010

Uzun, 2013, Chlorpyrifos induced hepatotoxic and hematologic changes in rats: the role of quercetin and catechin, Food Chem. Toxicol., 55, 549, 10.1016/j.fct.2013.01.056

Verma, 2007, In vivo chlorpyrifos induced oxidative stress: attenuation by antioxidant vitamins, Pestic. Biochem. Physiol., 88, 191, 10.1016/j.pestbp.2006.11.002

Wang, 2014, Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats, Toxicol. Appl. Pharmacol., 280, 169, 10.1016/j.taap.2014.06.011

Yamashita, 2014, Nrf2-inducing anti-oxidation stress response in the rat liver-new beneficial effect of lansoprazole, PLoS ONE, 9, 10.1371/journal.pone.0097419

Yamazaki, 2015, Role of the Keap1/Nrf2 pathway in neurodegenerative diseases, Pathol. Int., 65, 210, 10.1111/pin.12261

Yan, 2012, Repeated exposures to chlorpyrifos lead to spatial memory retrieval impairment and motor activity alteration, Neurotoxicol. Teratol., 34, 442, 10.1016/j.ntt.2012.05.053

Yang, 2008, Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase, Toxicol. Appl. Pharmacol., 228, 32, 10.1016/j.taap.2007.11.005

Yu, 2008, Apoptotic effect of organophosphorus insecticide chlorpyrifos on mouse retina in vivo via oxidative stress and protection of combination of vitamins C and E, Exp. Toxicol. Pathol., 59, 415, 10.1016/j.etp.2007.11.007

Yu, 2013, Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke, PLoS ONE, 8

Yu, 2015, Influence of chlorpyrifos oxon on the development and progression of Alzheimer's disease in amyloid precursor protein transgenic mice, Neuroimmunol. Neuroinflamm., 2, 31, 10.4103/2347-8659.149421

Zama, 2007, Chlorpyrifos-induced oxidative stress and tissue damage in the liver, kidney, brain and fetus in pregnant rats: the protective role of the butanolic extract of Paronychia argentea L, Indian J. Pharm., 39, 145, 10.4103/0253-7613.33434

Zhou, 2015, Protective effects of kaempferol against myocardial ischemia/reperfusion injury in isolated rat heart via antioxidant activity and inhibition of glycogen synthase kinase-3β