A molecular circadian clock operates in the parathyroid gland and is disturbed in chronic kidney disease associated bone and mineral disorder

Lewin, 1999, Rapid recovery of plasma ionized calcium after acute induction of hypocalcaemia in parathyroidectomized and nephrectomized rats, Nephrol Dial Transplant, 14, 604, 10.1093/ndt/14.3.604 Brown, 1993, Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid, Nature, 366, 575, 10.1038/366575a0 Lewin, 1997, Reversibility of experimental secondary hyperparathyroidism, Kidney Int, 52, 1232, 10.1038/ki.1997.448 Centeno, 2019, Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion, Nat Commun, 10, 4693, 10.1038/s41467-019-12399-9 Nielsen, 1996, A direct effect in vitro of phosphate on PTH release from bovine parathyroid tissue slices but not from dispersed parathyroid cells, Nephrol Dial Transplant, 11, 1762, 10.1093/oxfordjournals.ndt.a027665 Mace, 2018, Fibroblast growth factor (FGF) 23 regulates the plasma levels of parathyroid hormone in vivo through the FGF receptor in normocalcemia, but not in hypocalcemia, Calcif Tissue Int, 102, 85, 10.1007/s00223-017-0333-9 Kim, 2007, 1Alpha,25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter, Mol Endocrinol, 21, 334, 10.1210/me.2006-0231 Lopez, 2017, Leptin directly stimulates parathyroid hormone secretion, Endocrine, 56, 675, 10.1007/s12020-016-1207-z Yuan, 2011, FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH, J Bone Miner Res, 26, 2026, 10.1002/jbmr.433 el-Hajj Fuleihan, 1997, The parathyroid hormone circadian rhythm is truly endogenous—a general clinical research center study, J Clin Endocrinol Metab, 82, 281 Nordholm, 2019, Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats, Pflugers Arch, 471, 1079, 10.1007/s00424-019-02291-2 Lewin, 2000, PTHrP enhances the secretory response of PTH to a hypocalcemic stimulus in rat parathyroid glands, Kidney Int, 58, 71, 10.1046/j.1523-1755.2000.00142.x Lewin, 2003, Autoregulation in the parathyroid glands by PTH/PTHrP receptor ligands in normal and uremic rats, Kidney Int, 64, 63, 10.1046/j.1523-1755.2003.00056.x Huan, 2006, Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glands, J Am Soc Nephrol, 17, 1923, 10.1681/ASN.2005101136 Gekakis, 1998, Role of the CLOCK protein in the mammalian circadian mechanism, Science, 280, 1564, 10.1126/science.280.5369.1564 Chaix, 2016, The circadian coordination of cell biology, J Cell Biol, 215, 15, 10.1083/jcb.201603076 Patke, 2020, Molecular mechanisms and physiological importance of circadian rhythms, Nat Rev Mol Cell Biol, 21, 67, 10.1038/s41580-019-0179-2 Landgraf, 2016, NPAS2 compensates for loss of CLOCK in peripheral circadian oscillators, PLoS Genet, 12, e1005882, 10.1371/journal.pgen.1005882 Takahashi, 2017, Transcriptional architecture of the mammalian circadian clock, Nat Rev Genet, 18, 164, 10.1038/nrg.2016.150 Preitner, 2002, The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator, Cell, 110, 251, 10.1016/S0092-8674(02)00825-5 Meng, 2008, Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins, Neuron, 58, 78, 10.1016/j.neuron.2008.01.019 Luciano, 2018, CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues, J Biol Chem, 293, 9126, 10.1074/jbc.RA117.000773 Ko, 2006, Molecular components of the mammalian circadian clock, Hum Mol Genet, 15, R271, 10.1093/hmg/ddl207 Storch, 2002, Extensive and divergent circadian gene expression in liver and heart, Nature, 417, 78, 10.1038/nature744 Rey, 2011, Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver, PLoS Biol, 9, e1000595, 10.1371/journal.pbio.1000595 Lin, 2017, CLOCK acetylates ASS1 to drive circadian rhythm of ureagenesis, Mol Cell, 68, 198, 10.1016/j.molcel.2017.09.008 Robles, 2017, Phosphorylation is a central mechanism for circadian control of metabolism and physiology, Cell Metab, 25, 118, 10.1016/j.cmet.2016.10.004 Koike, 2012, Transcriptional architecture and chromatin landscape of the core circadian clock in mammals, Science, 338, 349, 10.1126/science.1226339 Stokkan, 2001, Entrainment of the circadian clock in the liver by feeding, Science, 291, 490, 10.1126/science.291.5503.490 Matsuo, 2003, Control mechanism of the circadian clock for timing of cell division in vivo, Science, 302, 255, 10.1126/science.1086271 Laranjeiro, 2013, Cyclin-dependent kinase inhibitor p20 controls circadian cell-cycle timing, Proc Natl Acad Sci U S A, 110, 6835, 10.1073/pnas.1217912110 Grechez-Cassiau, 2008, The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation, J Biol Chem, 283, 4535, 10.1074/jbc.M705576200 Hunt, 2007, Riding tandem: circadian clocks and the cell cycle, Cell, 129, 461, 10.1016/j.cell.2007.04.015 Casey, 2016, CLOCK regulates mammary epithelial cell growth and differentiation, Am J Physiol Regul Integr Comp Physiol, 311, R1125, 10.1152/ajpregu.00032.2016 Gery, 2006, The circadian gene Per1 plays an important role in cell growth and DNA damage control in human cancer cells, Mol Cell, 22, 375, 10.1016/j.molcel.2006.03.038 Fu, 2002, The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo, Cell, 111, 41, 10.1016/S0092-8674(02)00961-3 Wang, 1996, Parathyroid cell proliferation in the rat: effect of age and of phosphate administration and recovery, Endocrinology, 137, 4558, 10.1210/endo.137.11.8895317 Naveh-Many, 2018, Transcription factors that determine parathyroid development power PTH expression, Kidney Int, 93, 7, 10.1016/j.kint.2017.08.026 Kamitani-Kawamoto, 2011, MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development, J Bone Miner Res, 26, 2463, 10.1002/jbmr.458 Grigorieva, 2010, Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2, J Clin Invest, 120, 2144, 10.1172/JCI42021 Yamada, 2019, Gcm2 regulates the maintenance of parathyroid cells in adult mice, PLoS One, 14, e0210662, 10.1371/journal.pone.0210662 Morito, 2018, Transcription factor MafB may play an important role in secondary hyperparathyroidism, Kidney Int, 93, 54, 10.1016/j.kint.2017.06.023 Kebebew, 2004, GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism, Surgery, 136, 1261, 10.1016/j.surg.2004.06.056 Gravesen, 2018, Effect of inhibition of CBP-coactivated beta-catenin-mediated Wnt signalling in uremic rats with vascular calcifications, PLoS One, 13, e0201936, 10.1371/journal.pone.0201936 Rukov, 2016, Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing, Am J Physiol Renal Physiol, 310, F477, 10.1152/ajprenal.00472.2015 Gachon, 2007, Physiological function of PARbZip circadian clock-controlled transcription factors, Ann Med, 39, 562, 10.1080/07853890701491034 Damiola, 2000, Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus, Genes Dev, 14, 2950, 10.1101/gad.183500 Kawamura, 2018, Hypophosphatemia occurs with insulin administration during refeeding by total parenteral nutrition in rats, J Med Invest, 65, 50, 10.2152/jmi.65.50 Balsalobre, 2000, Resetting of circadian time in peripheral tissues by glucocorticoid signaling, Science, 289, 2344, 10.1126/science.289.5488.2344 Crosby, 2019, Insulin/IGF-1 drives PERIOD synthesis to entrain circadian rhythms with feeding time, Cell, 177, 896, 10.1016/j.cell.2019.02.017 Perelis, 2015, Pancreatic beta cell enhancers regulate rhythmic transcription of genes controlling insulin secretion, Science, 350, aac4250, 10.1126/science.aac4250 Naveh-Many, 1995, Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D, J Clin Invest, 96, 1786, 10.1172/JCI118224 Kilav, 1995, Parathyroid hormone gene expression in hypophosphatemic rats, J Clin Invest, 96, 327, 10.1172/JCI118038 Martin, 2005, Acute regulation of parathyroid hormone by dietary phosphate, Am J Physiol Endocrinol Metab, 289, E729, 10.1152/ajpendo.00065.2005 Sadowski, 2018, Identification of differential transcriptional patterns in primary and secondary hyperparathyroidism, J Clin Endocrinol Metab, 103, 2189, 10.1210/jc.2017-02506 Buchwald, 2004, Reduced p18INK4c, p21CIP1/WAF1 and p27KIP1 mRNA levels in tumours of primary and secondary hyperparathyroidism, Clin Endocrinol (Oxf), 60, 389, 10.1111/j.1365-2265.2004.01995.x Tokumoto, 2002, Reduced p21, p27 and vitamin D receptor in the nodular hyperplasia in patients with advanced secondary hyperparathyroidism, Kidney Int, 62, 1196, 10.1111/j.1523-1755.2002.kid585.x Mizobuchi, 2009, Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cells, J Bone Miner Res, 24, 1173, 10.1359/jbmr.090211 Canaff, 2009, Glial cells missing-2 (GCM2) transactivates the calcium-sensing receptor gene: effect of a dominant-negative GCM2 mutant associated with autosomal dominant hypoparathyroidism, Hum Mutat, 30, 85, 10.1002/humu.20827 Han, 2015, Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1, Mol Cell Endocrinol, 411, 113, 10.1016/j.mce.2015.04.018 Correa, 2002, Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism, Clin Endocrinol (Oxf), 57, 501, 10.1046/j.1365-2265.2002.01627.x Lewin, 2002, Persistent downregulation of calcium-sensing receptor mRNA in rat parathyroids when severe secondary hyperparathyroidism is reversed by an isogenic kidney transplantation, J Am Soc Nephrol, 13, 2110, 10.1097/01.ASN.0000024439.38838.03 Hofman-Bang, 2010, Increased parathyroid expression of klotho in uremic rats, Kidney Int, 78, 1119, 10.1038/ki.2010.215 Hassan, 2016, The fibroblast growth factor receptor mediates the increased FGF23 expression in acute and chronic uremia, Am J Physiol Renal Physiol, 310, F217, 10.1152/ajprenal.00332.2015 Hughes, 2010, JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets, J Biol Rhythms, 25, 372, 10.1177/0748730410379711