A model of lymphoedema in the rabbit's ear
Tóm tắt
The dorsal surface of the rabbit's ear is an easy place in which to produce a long-lasting lymphoedema, since the draining collecting lymphatics can readily be occluded. After six weeks of experimental lymphostasis the fine structure was examined and found to be identical with that observed elsewhere: The lymph capillary junctions were open here, as in some other regions where their support is not great. The benzopyrones produced their usual considerable reduction in the amounts of excess protein and oedema in the tissues. While they also reduced the concentration of protein in the lymphatics, they could not reduce their excessive dilatation, nor the increased numbers of open junctions, because the system was still occluded. After 32 weeks of experimental lymphostasis without benzopyrone therapy, much collagen was deposited and an increased number of macrophages present while protein concentrations were slightly reduced.
Tài liệu tham khảo
Altorfer, J., Clodius, L.: Chronic experimental lymphoedema of the extremities, pathological changes. Experientia (Basel) 32, 823 (1976)
Bolton, T., Casley-Smith, J.R.: An in vitro demonstration of proteolysis by macrophages and its increase with coumarin. Experientia (Basel) 31, 271 (1975)
Casley-Smith, J.R.: The actions of the benzopyrones on the blood-tissue-lymph system. Folia angiol. (Pisa) 24, 7 (1976)
Casley-Smith, J.R.: Lymph and lymphatics. In: Microcirculation. Vol. II. Eds.: G. Kaley and B.M. Altura. Baltimore: University Park Press 1977 (in press)
Casley-Smith, J.R.: The structural basis for the conservative treatment of lymphedema. In: Lymphedema. pp. 13; Ed.: L. Clodius; Stuttgart: G. Thieme 1977
Casley-Smith, J.R., Clodius, L., Földi, M.: Experimental blood vascular and lymphatic occlusion in the rabbit ear and the effect of benzopyrones. Arzneimittel-Forsch. 27, 379 (1977)
Casley-Smith, J.R., Földi-Börcsök, E., Földi, M.: The fine structural aspects of lymphoedema in various tissues and the effects of treatment with coumarin and troxerutin. Brit. J. exp. Path. 55, 88 (1974)
Casley-Smith, J.R., Piller, N.B.: Investigations on the mode of action of the benzopyrones in high-protein oedema. In: Ergebnisse Angiologie. Vol. 13. III-Ringelheimer Symposium. Ed.: M. Földi; Stuttgart-New York: F.K. Schattauer 1977
Casley-Smith, J.R., Piller, N.B.: The mode of action of coumarin and related compounds in the treatment of edema. In: Lymphedema. pp. 33; Ed.: L. Clodius; Stuttgart: G. Thieme 1977
Casley-Smith, J.R.: The estimation of protein concentrations in thin sections by densitometric electron microscopy. J. Microsc. (Oxf.) (submitted for publication)
Clodius, L., Uhlschmid, G., Smahel, J., Altorfer, J.: Microsurgery and lymphatics. In: Symposium on Microsurgery, Eds.: A.I. Daniller and B. Strauch; St. Louis: C.V. Mosby 1976
Clodius, L., Wirth, W.: A new experimental model for chronic lymphoedema of the extremities. Chir. plastica (Berlin) 2, 115 (1974)
Clodius, L., Földi, M.: Eine Methode zur Herbeiführung einer numerisch erfaßbaren Gangrän am Kaninchenohr; die therapeutische Wirkung einer Behandlung mit Benzopyron. Schweiz. Rundschau Med. (Praxis) 65, 514 (1976)
Clodius, L.: The experimental basis for the surgical treatment of lymphedema. In: Lymphedema. pp. 43; Stuttgart: G. Thieme 1977
Földi, M.: New trends in lymphology. Experientia (Basel) 32, 817 (1976)
Gabor, M.: Pharmacological effects of flavonoids on blood vessels. Angiologica 9, 355 (1972)
Piller, N.B., Casley-Smith, J.R.: The effect of coumarin on protein and PVP clearance from rat legs with various high protein oedemas. Brit. J. exp. Path. 56, 439 (1975)
Piller, N.B.: The ineffectiveness of coumarin treatment of thermal oedema of macrophage-free rats. Brit. J. exp. Path. 57, 170 (1976)
Piller, N.B., Clodius, L.: The use of a tissue tonometer as a diagnostic aid in lymphoedema. A determination of its conservative treatment with benzopyrones. Lymphology 9, 127 (1977)
Willoughby, D.A., Di Rosa, M.: A unifying concept for inflammation. In: Immunopathology of inflammation. Excerpta med. (Amst.), Internat. Congr. Ser. 229, 28 (1970)