A mild cold stress that increases resistance to heat lowers FOXO translocation in Drosophila melanogaster

Biogerontology - Tập 18 - Trang 791-801 - 2017
Cédric Polesello1, Eric Le Bourg2
1Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI Toulouse), Université de Toulouse, CNRS, UPS, Toulouse, France
2Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI Toulouse), Université de Toulouse, CNRS, UPS, Toulouse, France

Tóm tắt

Previous studies have shown that subjecting Drosophila melanogaster flies to a mild stress at young or middle age can increase lifespan and resistance to severe stresses throughout life and that the NF-κB-like transcription factor DIF, the 70 kDa heat-shock proteins, and the Drosophila Forkhead box class O (dFOXO) transcription factor could explain some of these effects. The present study showed that two dFOXO mutants do not survive longer heat if previously subjected to a mild cold stress, contrarily to wild-type flies. This cold pretreatment had nearly no effect on dFOXO nuclear translocation in wild-type males. Heat stress strongly increased dFOXO translocation, but this effect was lowered in cold-pretreated males. Because cold-pretreated wild-type males survived longer heat and had nevertheless a lower dFOXO translocation after this heat stress, one can conclude that dFOXO is required to resist heat but that the cold pretreatment makes that other mechanisms partly substitute to dFOXO translocation.

Tài liệu tham khảo

Carter ME, Brunet A (2007) FOXO transcription factors. Curr Biol 17:R113–R114 Cognigni P, Bailey AP, Miguel-Aliaga I (2011) Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. Cell Metab 13:92–104 Cypser JR, Johnson TE (2003) Hormesis in Caenorhabditis elegans dauer-defective mutants. Biogerontology 4:203–214 Donovan MR, Marr MT 2nd (2016) dFOXO activates large and small heat shock protein genes in response to oxidative stress to maintain proteostasis in Drosophila. J Biol Chem 291:19042–19050 Galbadage T, Hartman PS (2008) Repeated temperature fluctuation extends the life span of Caenorhabditis elegans in a daf-16-dependent fashion. Mech Ageing Dev 129:507–514 Giannakou ME, Goss M, Partridge L (2008) Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging Cell 7:187–198 Hazelrigg T, Levis R, Rubin GM (1984) Transformation of white locus DNA in Drosophila: dosage, compensation, zeste interaction, and position effects. Cell 36:469–481 Henten AMV, Loeschcke V, Pedersen JG, Leisner JJ, Sarup P (2016) Injuries can prolong lifespan in Drosophila melanogaster males. Biogerontology 17:337–346 Jünger MA, Rintelen F, Stocker H, Wasserman JD, Veégh M, Radimerski T, Greenberg ME, Hafen E (2003) The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol 2(3):20 Kristensen TN, Sørensen JG, Loeschcke V (2003) Mild heat stress at a young age in Drosophila melanogaster leads to increased Hsp70 synthesis after stress exposure later in life. J Genet 82:89–94 Le Bourg E (2007) Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster. Biogerontology 8:431–444 Le Bourg E (2008) Three mild stresses known to increase longevity in Drosophila melanogaster flies do not increase resistance to oxidative stress. Am J Pharmacol Toxicol 3:137–143 Le Bourg E (2009) Hormesis, aging, and longevity. Biochim Biophys Acta 1790:1030–1039 Le Bourg E (2010) Combined effects of suppressing live yeast and of a cold pretreatment on longevity, aging and resistance to several stresses in Drosophila melanogaster. Biogerontology 11:245–254 Le Bourg E (2011) A cold stress applied at various ages can increase resistance to heat and fungal infection in aged Drosophila melanogaster flies. Biogerontology 12:185–193 Le Bourg E (2012) Combined effects of two mild stresses (cold and hypergravity) on longevity, behavioral aging, and resistance to severe stresses in Drosophila melanogaster. Biogerontology 13:313–328 Le Bourg E (2013) Fasting can protect young and middle-aged Drosophila melanogaster flies against a severe cold stress. Biogerontology 14:513–529 Le Bourg E (2016a) Life-time protection against severe heat stress by exposing young Drosophila melanogaster flies to a mild cold stress. Biogerontology 17:409–415 Le Bourg E (2016b) The somatotropic axis may not modulate ageing and longevity in humans. Biogerontology 17:421–429 Le Bourg E, Fournier D (2004) Is lifespan extension accompanied by improved antioxidant defences? A study of superoxide dismutase and catalase in Drosophila melanogaster flies that lived in hypergravity at young age. Biogerontology 5:261–266 Le Bourg E, Massou I (2015) Fasting increases survival to cold in FOXO, DIF, autophagy mutants and in other genotypes of Drosophila melanogaster. Biogerontology 16:411–421 Le Bourg E, Rattan SIS (eds) (2008) Mild stress and healthy aging. Applying hormesis in aging research and interventions. Springer, Berlin Le Bourg E, Valenti P, Payre F (2002) Lack of hypergravity-associated longevity extension in Drosophila melanogaster flies overexpressing hsp70. Biogerontology 3:355–364 Le Bourg E, Malod K, Massou I (2012) The NF-κB-like factor DIF could explain some positive effects of a mild stress on longevity, behavioral aging, and resistance to strong stresses in Drosophila melanogaster. Biogerontology 13:455–465 Maklakov AA, Rowe L, Friberg U (2015) Why organisms age: evolution of senescence under positive pleiotropy? BioEssays 37:802–807 Martins R, Lithgow GJ, Link W (2016) Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell 15:196–207 Moskalev AA, Plyusnina EN, Shaposhnikov MV (2011) Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms. Biogerontology 12:253–263 Puig O, Mattila J (2011) Understanding forkhead box class O function: lessons from Drosophila melanogaster. Antioxid Redox Signal 14:635–647 Rattan SIS, Le Bourg E (eds) (2014) Hormesis in health and disease. CRC Press, Boca Raton Slack C, Giannakou ME, Foley A, Goss M, Partridge L (2011) dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell 10:735–748 Slaidina M, Delanoue R, Gronke S, Partridge L, Léoopold P (2009) A Drosophila insulin-like peptide promotes growth during nonfeeding states. Dev Cell 17:874–884 Sørensen JG, Kristensen TN, Kristensen KV, Loeschcke V (2007) Sex specific effects of heat induced hormesis in Hsf-deficient Drosophila melanogaster. Exp Gerontol 42:1123–1129 Zheng X, Yang Z, Yue Z, Alvarez JD, Sehgal A (2007) FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc Natl Acad Sci USA 104:15899–15904