A microfluidic device for capturing malaria-infected red blood cells by magnetophoretic force using an array of V- and W-shaped nickel microstructures
Tóm tắt
A microfluidic device with ferromagnetic microstructures designed to locally induce strong magnetophoretic force for capturing infected blood cells has been employed for malaria diagnosis for a long time. In this study, new configurations of V- and W-shaped nickel microstructures fabricated by an electroplating process and magnet arrays were proposed to enhance the capture efficacy from the conventional square one. The simulation of magnetophoretic and hydrodynamic forces was conducted to reveal the capture mechanism of them. After that, the microfluidic device was built and tested. The experimental results with magnetic beads showed that capture efficiency increased by almost twice as much when compared to the conventional square microstructures. Additionally, malaria-infected blood cells at the level of parasitemia at 2%, 10%, and 80% were tested, and the capture efficiency was in agreement with the tests with magnetic beads.
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