A mechanism for sudden infant death syndrome (SIDS): Stress-induced leak via ryanodine receptors

Willinger, 1991, Defining the sudden infant death syndrome (SIDS): deliberations of an expert panel convened by the National Institute of Child Health and Human Development, Pediatric Pathol, 11, 677, 10.3109/15513819109065465 1992, Positioning and SIDS, Pediatrics, 89, 1120, 10.1542/peds.89.6.1120 Willinger, 1994, Infant sleep position and risk for sudden infant death syndrome: report of meeting held January 13 and 14, 1994, National Institutes of Health, Bethesda, MD, Pediatrics, 93, 814, 10.1542/peds.93.5.814 Gibson, 1995, Infant sleep position following new AAP guidelines, Pediatrics, 96, 69 Dwyer, 1995, The contribution of changes in the prevalence of prone sleeping position to the decline in sudden infant death syndrome in Tasmania, JAMA, 273, 783, 10.1001/jama.1995.03520340039033 Guyer, 1999, Annual summary of vital statistics—1998, Pediatrics, 104, 1229, 10.1542/peds.104.6.1229 Martin, 2005, Annual summary of vital statistics—2003, Pediatrics, 115, 619, 10.1542/peds.2004-2695 Hoffman, 1988, Risk factors for SIDS, Ann N Y Acad Sci, 533, 13, 10.1111/j.1749-6632.1988.tb37230.x Hoffman, 1992, Epidemiology of the sudden infant death syndrome: maternal, neonatal, and postneonatal risk factors, Clin Perinatol, 19, 717, 10.1016/S0095-5108(18)30427-5 Ponsonby, 1993, Factors potentiating the risk of sudden infant death syndrome associated with the prone position, New Eng J Med, 329, 377, 10.1056/NEJM199308053290601 Fleming, 1996, Environment of infants during sleep and risk of the sudden infant death syndrome: results of 1993–5 case-control study for confidential inquiry into stillbirths and deaths in infancy, BMJ, 313, 191, 10.1136/bmj.313.7051.191 Getahun, 2004, Maternal and obstetric risk factors for sudden infant death syndrome in the United States, Obstet Gynecol, 103, 646, 10.1097/01.AOG.0000117081.50852.04 Valdes-Dapena, 1973, Editorial: Sudden, unexpected and unexplained death in infancy—a status report—1973, N Engl J Med, 289, 1195, 10.1056/NEJM197311292892213 Guntheroth, 1989, Theories of cardiovascular causes in sudden infant death syndrome, J Am Coll Cardiol, 14, 443, 10.1016/0735-1097(89)90200-3 Schwartz, 1998, Prolongation of the QT interval and the sudden infant death syndrome, N Engl J Med, 338, 1709, 10.1056/NEJM199806113382401 Schwartz, 2000, A molecular link between the sudden infant death syndrome and the long-QT syndrome, N Engl J Med, 343, 262, 10.1056/NEJM200007273430405 Valdes-Dapena, 1985, Are some crib deaths sudden cardiac deaths?, J Am Coll Cardiol, 5, 113B, 10.1016/S0735-1097(85)80539-8 Schwartz, 1976, Cardiac sympathetic innervation and the sudden infant death syndrome: a possible pathogenic link, Am J Med, 60, 167, 10.1016/0002-9343(76)90425-3 Ackerman, 2001, Postmortem molecular analysis of SCN5A defects in sudden infant death syndrome, JAMA, 286, 2264, 10.1001/jama.286.18.2264 Tester, 2005, Sudden infant death syndrome: how significant are the cardiac channelopathies?, Cardiovasc Res, 67, 388, 10.1016/j.cardiores.2005.02.013 Arnestad, 2007, Prevalence of long QT syndrome gene variants in sudden infant death syndrome, Circulation, 115, 361, 10.1161/CIRCULATIONAHA.106.658021 Tester, 2005, Spectrum and prevalence of cardiac ryanodine receptor (RyR2) mutations in a cohort of unrelated patients referred explicitly for long QT syndrome genetic testing, Heart Rhythm, 2, 1099, 10.1016/j.hrthm.2005.07.012 Allouis, 2005, Unusual clinical presentation in a family with catecholaminergic polymorphic ventricular tachycardia due to a G14876A ryanodine receptor gene mutation, Am J Cardiol, 95, 700, 10.1016/j.amjcard.2004.10.057 Priori, 2001, Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia, Circulation, 103, 196, 10.1161/01.CIR.103.2.196 Laitinen, 2001, Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia, Circulation, 103, 485, 10.1161/01.CIR.103.4.485 Priori, 2002, Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia, Circulation, 106, 69, 10.1161/01.CIR.0000020013.73106.D8 Krous, 2004, Sudden infant death syndrome and unclassified sudden infant deaths: a definitional and diagnostic approach, Pediatrics, 114, 234, 10.1542/peds.114.1.234 Marx, 2000, PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts, Cell, 101, 365, 10.1016/S0092-8674(00)80847-8 Bers, 1994, A practical guide to the preparation of Ca2+ buffers, Meth Cell Biol, 40, 3, 10.1016/S0091-679X(08)61108-5 Lehnart, 2004, Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak, Circulation, 109, 3208, 10.1161/01.CIR.0000132472.98675.EC Wehrens, 2003, FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death, Cell, 113, 829, 10.1016/S0092-8674(03)00434-3 Priori, 2002, Natural history of Brugada syndrome: insights for risk stratification and management, Circulation, 105, 1342, 10.1161/hc1102.105288 Tester, 2004, Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner’s cases, Mayo Clin Proc, 79, 1380, 10.4065/79.11.1380 Thiedke, 2001, Sleep disorders and sleep problems in childhood, Am Fam Phys, 63, 277 Moise, 1996, Relationship of ventricular tachycardia to sleep/wakefulness in a model of sudden cardiac death, Pediatric Res, 40, 344, 10.1203/00006450-199608000-00025 Lavery, 1997, Nonuniform nighttime distribution of acute cardiac events—a possible effect of sleep states, Circulation, 96, 3321, 10.1161/01.CIR.96.10.3321 Simpson, 2001, Infant stress and sleep deprivation as an aetiological basis for the sudden infant death syndrome, Early Hum Devel, 61, 1, 10.1016/S0378-3782(00)00127-4 Vatta, 2006, Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome, Circulation, 114, 2104, 10.1161/CIRCULATIONAHA.106.635268 Cronk, 2007, Novel mechanism for sudden infant death syndrome: persistent late sodium current secondary to mutations in caveolin-3, Heart Rhythm, 4, 161, 10.1016/j.hrthm.2006.11.030 Ackerman, 2004, Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian, and Hispanic individuals: implications for arrhythmogenic susceptibility and Brugada/long QT syndrome genetic testing, Heart Rhythm, 1, 600, 10.1016/j.hrthm.2004.07.013 Ackerman, 2003, Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome, Mayo Clinic Proc, 78, 1479, 10.4065/78.12.1479