A low steady HBsAg seroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: a systematic review
Tóm tắt
To address the relationship between hepatitis B virus (HBV) endemicity and HBV-related liver diseases in Mexico. Research literature reporting on HBsAg and antibody to hepatitis B core antigen (anti-HBc) prevalence in Mexican study groups were searched in NLM Gateway, PubMed, IMBIOMED, and others. Weighted mean prevalence (WMP) was calculated from the results of each study group. A total of 50 studies were analyzed. Three nationwide surveys revealed an HBsAg seroprevalence of less than 0.3%. Horizontal transmission of HBV infection occurred mainly by sexual activity and exposure to both contaminated surgical equipment and body fluids. High-risk groups exposed to these factors included healthcare workers, pregnant women, female sex workers, hemodialysis patients, and emergency department attendees with an HBsAg WMP ranging from 1.05% (95% confidence interval [CI], 0.68–1.43) to 14.3% (95% CI, 9.5–19.1). A higher prevalence of anti-HBc in adults than those younger than 20 years was associated with the main risk factors. Anti-HBc WMP ranged from 3.13% (95% CI, 3.01–3.24) in blood donors to 27.7% (95% CI, 21.6–33.9) in hemodialysis patients. A heterogeneous distribution of HBV infection was detected, mainly in native Mexican groups with a high anti-HBc WMP of 42.0% (95% CI, 39.5–44.3) but with a low HBsAg WMP of 2.9% (95% CI 2.08–3.75). Estimations of the Mexican population growth rate and main risk factors suggest that HBsAg seroprevalence has remained steady since 1974. A low HBsAg prevalence is related to the low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma (HCC) previously reported in Mexico.
Tài liệu tham khảo
Mast EE, Alter MJ, Margolis HS. Strategies to prevent and control hepatitis B and C virus infections: a global perspective. Vaccine 1999;17:1730–1733. doi:10.1016/S0264-410X(98)00415-0
World Health Organization. Department of Communicable Disease Surveillance and Response 2002, Hepatitis B [cited December 2007]. Available from: http://www.who.int/emc
Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004;11:97–107. doi:10.1046/j.1365-2893.2003.00487.x
Hou J, Liu Z, Gu F. Epidemiology and prevention of hepatitis B virus infection. Int J Med Sci 2005;2(1):50–57
Gish RG, Gadano AC. Chronic hepatitis B: current epidemiology in the Americas and implications for management. J Viral Hepat 2006;13(12):787–798. doi:10.1111/j.1365-2893.2006.00787.x
Fay OH. Hepatitis B in Latin America: epidemiological patterns and eradication strategy. The Latin American Regional Study Group. Vaccine 1990;8(Suppl):S100–S106
Silveira TR, da Fonseca JC, Rivera L, Fay OH, Tapia R, Santos JI, et al. Hepatitis B seroprevalence in Latin America. Rev Panam Salud Pública/Pan. Am J Public Health 1999;6(6):378–383
Ramiro Cruz J, Perez-Rosales MD. Availability, safety, and quality of blood for transfusion in the Americas. Rev Panam Salud Pública 2003;13(2–3):103–110
Campos RH, Mbayed VA, Pineiro Y, Leone FG. Molecular epidemiology of hepatitis B virus in Latin America. J Clin Virol 2005;34(Suppl 2):S8–S13. doi:10.1016/S1386-6532(05)80028-9
Ponce JG, Cadenas LF, Garcia F, Leon G, Blitz-Dorfman L, Monsalve F, et al. Alta prevalencia de marcadores de hepatitis B y C en una comunidad de indigentes en Caracas Venezuela. Invest Clin 1994;35(3):123–129
Echevarria JM, Leon P. Epidemiology of viruses causing chronic hepatitis among populations from the Amazon Basin and related ecosystems. Cad Saude Publica 2003;19(6):1583–1591. doi:10.1590/S0102-311X2003000600003
Miyakawa Y, Mizokami M. Classifying hepatitis B virus genotypes. Intervirology 2003;46(6):329–338. doi:10.1159/000074988
Norder H, Louroucé AM, Coursaget P, Echevarria JM, Lee SD, Mushahwar JK, et al. Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes and HBsAg subtypes. Intervirology 2004;47(6):289–309. doi:10.1159/000080872
Sanchez LV, Maldonado M, Bastidas-Ramirez BE, Norder H, Panduro A. Genotypes and S-gene variability of Mexican hepatitis B virus strains. J Med Virol 2002;68(1):24–32. doi:10.1002/jmv.10166
Sanchez LV, Tanaka Y, Maldonado M, Mizokami M, Panduro A. Difference of hepatitis B virus genotype distribution in two groups of Mexican patients with different risk factors. Intervirology 2007;50(1):9–15. doi:10.1159/000096307
Arauz-Ruiz P, Norder H, Robertson BH, Magnius LO. Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol 2002;83:2059–2073
Nakajima A, Usui M, Huy TT, Hlaing NKT, Masaki N, Sata T, et al. Full-length sequence of hepatitis B virus belonging to genotype H identified in a Japanese patient with chronic hepatitis. Jpn J Infect Dis 2005;58:244–246
Mbayed VA, Barbini L, Lopez JL, Campos RH. Phylogenetic analysis of the hepatitis B virus (HBV) genotype F including Argentine isolates. Arch Virol 2001;146(9):1803–1810. doi:10.1007/s007050170066
Norder H, Arauz-Ruiz P, Blitz L, Pujol FH, Echevarria JM, Magnius LO. The T (1858) variant predisposing to the precore stop mutation correlates with one or two major genotype F hepatitis B virus clades. J Gen Virol 2003;84(Pt 8):2083–2087. doi:10.1099/vir.0.19034-0
Huy TT, Ushijima H, Sata T, Abe K. Genomic characterization of HBV genotype F in Bolivia: genotype F subgenotypes correlate with geographic distribution and T (1858) variant. Arch Virol 2006;151(3):589–597. doi:10.1007/s00705-005-0671-1
Khan A, Tanaka Y, Saito H, Ebinuma H, Sekiguchi H, Iwama H, et al. Transmission of hepatitis B virus (HBV) genotypes among Japanese immigrants and natives in Bolivia. Virus Res 2008;132(1–2):174–180
Kao JH, Chen PJ, Lai MY, Chen DJ. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000;118:554–559. doi:10.1016/S0016-5085(00)70261-7
Kao JM. Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J Gastroenterol Hepatol 2002;17(6):643–650. doi:10.1046/j.1440-1746.2002.02737.x
Tanaka Y, Mizokami M. Genetic diversity of hepatitis B virus as an important factor associated with differences in clinical outcomes. J Infect Dis 2007;195(1):1–4. doi:10.1086/509898
Ganem D, Prince AM. Hepatitis B virus infection—natural history and clinical consequences. N Engl J Med 2004;350(11):1118–1129. doi:10.1056/NEJMra031087
Pan CQ, Zhang JX. Natural history and clinical consequences of hepatitis B virus infection. Int J Med Sci 2005;2(1):36–40
Cortes-Espinoza T, Mondragón-Sanchez R, Hurtado-Andrade H, Sanchez-Cisneros R. Hepatocellular carcinoma and hepatic cirrhosis in Mexico: a 25 year necroscopy review. Hepatogastroenterology 1997;44(17):1401–1403
Vivas Arceo C, Bastidas Ramírez BE, Panduro A. Hepatocellular carcinoma is rarely present in Western Mexico. Hepatol Res 1999;16(1):26–35. doi:10.1016/S1386-6346(99)00035-2
Méndez-Sánchez N, Aguilar-Ramírez JR, Reyes A, Dehesa M, Juárez A, Castañeda B, et al. Etiology of liver cirrhosis in Mexico. Ann Hepatol 2004;3(1):30–33
Olaiz-Fernández G, Rivera-Dommarco J, Shamah-Levy T, Rojas R, Villalpando-Hernandez S, Hernández-Avila M, et al. Encuesta Nacional de Salud y Nutricion 2006. Cuernavaca Morelos (Mexico): Instituto Nacional de Salud Pública; 2006. p. 1–132 [cited December 2007]. Available from: http://www.insp.mx/ensanut/ensanut2006.pdf
Green S. Systematic reviews and meta-analysis. Singapore Med J 2005;46(6):270–274
Clarke M. Systematic reviews and the Cochrane Collaboration [cited November 2007]. Available from: http://www.cochrane.org/docs/whycc.htm
Landa L. Seroepidemiología de la hepatitis B. Gac Med Mex 1976;111(2):108–114
Chiquete E, Panduro A. Low prevalence of anti-hepatitis C virus antibodies in Mexico: a systematic review. Intervirology 2007;50:1–8. doi:10.1159/000096306
Valdespino JL, Conde-González CJ, Olaiz-Fernandez G, Palma O, Sepúlveda J. Prevalence of hepatitis B infection and carrier status among adults in Mexico. Salud Publica Mex 2007;49(Suppl 3):S404–S411
Marín LA, Luis LA, Ortega RM, López PS, Montiel MG. Marcadores serológicos indirectos (ALAT y anti-HBc) para hepatitis noA noB en donadores de sangre de la ciudad de Puebla. In Mem XXXI Jornada Agrup Mex Estudio Hematol; Oct 1990; Monterrey, Nuevo León, Mexico
Álvarez Muñoz MT, Bustamante Calvillo ME, Guiscafre Gallardo JP, Muñoz O. Hepatitis B y Delta: prevalencia de marcadores seroepidemiológicos en donadores de sangre voluntarios y su grupo familiar. Gac Med Mex 1991;127(5):399–404
Rivas Velazco R, Palomares BR, Gómez E, Moreno G, Martínez I, Badillo H. Enfermedades transmisibles en donadores de sangre en la zona oriente de la ciudad de México. In Mem XXXII Jornada Agrup Mex Estudio Hematol Oct 1991; Xalapa, Veracruz, Mexico
Rivas R, Gómez Martínez E, Martínez Pérez I, López Flores H, Fernández Jiménez A, Palomares B. Comportamiento de la seroprevalencia de enfermedades transmisibles en donadores de la zona oriente del Valle de México. In Mem XXXIV Jornada Agrup Mex Estudio Hematol Junio 1993; Guadalajara, Jalisco, Mexico
Souto Meiriño CA, Simón Domínguez J, Pulido Priego MA, Hernández Pérez A, García Hernández IC, Río Chiriboga CA. Prevalencia de marcadores para hepatitis A, B y C en un hospital de México. Salud Publica Mex 1994;36(3):257–262
Rivas Llamas R. Seroprevalencia y tendencia de la infección por VIH, VHB, VHC en donadores de sangre en la ciudad de Culiacán. Rev Med IMSS Mex 1996;34(6):487–493
Romero D, Villanueva M, Guzmán E, Bravo A. Prevalencia de anticuerpos contra hepatitis C en una población de disponentes familiares en la ciudad de México. In Mem XXXVIII Jornada Agrup Mex Estudio Hematol Mayo, 1997, León, Guanajuato, Mexico
Ayala Gaytan JJ, Guerra Avalos FJ, Mora Brondo P, Casillas Romo A. Prevalencia de marcadores virales para hepatitis B, C y Virus de la Inmunodeficiencia Humana en donadores de sangre voluntarios en el Noroeste de México. Rev Gastroenterol Mex 1997;62(4):250–253
Pita-Ramírez L, Torres-Ortiz GE. Prevalencia de anticuerpos virales y reaginas luéticas en donadores de sangre de un hospital. Rev Invest Clin 1997;49:475–480
Romero Martínez E. Selección de donadores sanguíneos: identificación de anti-HBc para evitar hepatitis postransfusional. Rev Med IMSS Mex 1998;36(4):327–332
Ramírez-Barragan J, Muñoz-Valle JF, Navarro-Hernández RE. Frecuencia de anticuerpos contra el HIV, HCV y HBsAg en donadores familiares en el Hospital del Carmen de la ciudad de Guadalajara, Jalisco. Rev Mex Patol Clin 1999;46(4):243–248
Méndez-Sánchez N, Baptista González H, Sánchez Gómez RH, Bordes Aznar J, Uribe Esquivel M. Prevalencia de hepatitis B y C en donadores de sangre en un hospital de tercer nivel de la ciudad de México. Salud Publica Mex 1999;41:475–478
Tristan Rojas CM, Nájera Tobias E, Cázares Taméz R, Flores Aréchiga A. Estudio comparativo de la seroprevalencia observada en diferentes bancos de sangre de la Republica Mexicana. XXVIII Congreso de Patología Clínica. Rev Mex Patol Clin 1999;46(1):34–35
Carreto-Velez MA, Carrada-Bravo T, Martínez-Magdaleno A. Seroprevalencia de VHB, VHC y VIH de donadores de sangre en Irapuato, México. Salud Publica Mex 2002;45(Suppl 5):S690–S693
Flores-Padilla L, Trejo-Franco J, Becerril-Brito J. Prevalencia de seromarcadores de hepatitis B y C en donadores del IMSS, Cd. Juarez, Chihuahua. XXVII Congreso Anual de la Asociación Mexicana de Infectologia y Microbiologia Clínica, A.C. 2002;22(3):106
Monteon VM, Reyes-Lopez PA, Sosa-Palacio A, Leon-Tello G, Martinez-Murguia J, Sosa-Jurado F. Heterogeneous distribution of the prevalence of anti-Trypsanosoma cruzi antibodies among blood donors in the State of Puebla, Mexico. Salud Publica Mex 2005;47(2):116–125. doi:10.1590/S0036-36342005000200005
Rivera-Lopez MRF, Zavala-Méndez C, Arenas-Esqueda A. Prevalencia de seropositividad para VIH, hepatitis B y C en donadores de sangre. Gac Med Mex 2004;140(6):657–660
Chiquete E, Sanchez LV, Becerra G, Quintero A, Maldonado M, Panduro A. Performance of the serologic and molecular screening of blood donations for the hepatitis B and C viruses in a Mexican Transfusion Center. Ann Hepatol 2005;4(4):275–278
García-Montalvo BM. Seropositividad de VIH, VHB, VHC y Treponema pallidum en donadores de sangre en el Sureste de Mexico. Rev Invest Clin 2006;58(6):567–572
Pita-Ramírez L, Rodríguez-Mejorada M. Comparación de dos poblaciones de sangre de la ciudad de Morelia. XLVII Congreso Nacional de Hematologia: Medicina Transfusional. Revista de Hematología 2006;7 (Suppl 1):S73
Cacique-Almazán J, Pérez-Martínez E, Gómez-Bravo A, Ángeles-Chimal JS. XLVII Congreso Nacional de Hematología: Medicina Transfusional. Rev Hematol 2006;7(Suppl 1):S71
Vázquez-Flores JA, Valiente-Banuet L, Marín y López RA, Sanchez-Guerrero SA. La seguridad de las reservas sanguíneas en la Republica Mexicana durante los años 1999 a 2003. Rev Invest Clin 2006;58(2):101–108
Álvarez Muñoz MT, Vázquez Rosales JG, Bustamante Calvillo ME, del Rey Pineda G, Arredondo García JL. Prevalencia de marcadores serológicos para los virus B y C de la hepatitis en una cohorte de mujeres embarazadas del Valle de México. Bol Med Hosp Infant Mex 1995;52(3):143–147
Ortiz Ibarra F, Figueroa Damian R, Lara Sánchez J, Arredondo García JL, Ahued Ahued JR. Prevalencia de marcadores serológicos de los virus de la hepatitis A, B, C y D en embarazadas. Salud Publica Mex 1996;38:317–322
Hernández Arriaga JL, Ramírez Crespo A, a Gómez M, Castellanos Martínez J. Marcadores serológicos de hepatitis B en la etapa perinatal. Bol Med Hosp Infant Mex 2000;57(12):682–685
Vazquez Martínez JL, Coreño Juárez MO, Montaño Estrada LF, Attlan M, Gómez Dantés H. Seroprevalencia de hepatitis B en mujeres embarazadas en México. Salud Publica Mex 2003;45(3):165–170
Kerschenobich D, Hurtado R, Collawin C, Bobadilla J, Cabrera G, Borovoy J, et al. Seroprevalencia de marcadores virales de hepatitis B en profesionales de la salud. Estudio multicéntrico en México. Rev Invest Clin 1990;42(4):251–256
Navarrete-Navarro S, Alvarez-Muñoz MA, Bustamante C, Vallejo Aguilar OJ, Muñoz O, Santos-Preciado JI, et al. Protección contra hepatitis B en trabajadores de salud con vacuna de DNA recombinante. Bol Med Hosp Infant Mex 1992;49(11):739–742
Flores Calderón J, Álvarez Muñoz MT, Bustamante Calvillo ME, Vázquez Rosales G, Reyes Morales H. Prevalencia de marcadores serológicos para el virus de la hepatitis B en personal de un hospital pediátrico. Bol Med Hosp Infant Mex 1994;51:99–104
Villasis-Keever MA, Peña LA, Miranda Novales G, Alvarez Muñoz MT, Damasio Santana RA, López Fuentes G, et al. Prevalence of serological markers against measles, varicella, hepatitis B, hepatitis C, and human immunodeficiency virus among medical residents in Mexico. Prev Med 2001;32(5):424–428. doi:10.1006/pmed.2001.0825
Méndez-Sánchez N, Motola-Kuba D, Zamora-Valdés D, Sánchez-Lara K, Ponciano-Rodríguez G, Uribe-Ramos MH, et al. Risk factors and prevalence of hepatitis virus B and C serum markers among nurses at a tertiary-care hospital in Mexico City, Mexico: a descriptive study. Ann Hepatol 2006;5(4):276–280
Flores Castañeda MS, García Méndez BL, Tijerina Menchaca R. Seropositividad de la infección por HCV y VHB en estudiantes universitarios del Estado de Nuevo León, México. Rev Gastroenterol Mex 1996;61(4):327–331
Hyams KC, Escamilla J, Lozada Romero R, Macareno Alvarado E, Bonilla Giraldo N, Papadimos TJ, et al. Hepatitis B infection in a non-drug abusing prostitute population in Mexico. Scand J Infect Dis 1990;22(5):527–531. doi:10.3109/00365549009027091
Valdespino Gómez JL, García García ML, del Río Chiriboga C, Loo Méndez E, López Sotelo A. Las enfermedades de transmisión sexual y la epidemia de VIH/SIDA. Salud Publica Mex 1995;37(6):549–555
Uribe-Salas F, Hernández-Giron C, Conde-González C, Cruz-Valdez A, Juárez-Figueroa L, Hernández-Avila M. Characteristics related to STD/HIV in men working in bars with prostitutes in Mexico City. Salud Publica Mex 1995;37:385–393
Juárez-Figueroa LA, Uribe-Salas FJ, Conde-González CJ, Hernández-Avila M, Hernández-Nevarez P, Uribe-Zúñiga P, et al. Hepatitis B markers in men seeking human immunodeficiency virus antibody testing in Mexico City. Sex Transm Dis 1997;24(4):211–217
Hernández-Girón C, Uribe-Salas F, Conde-González C, Cruz-Valdez A, Juárez-Figueroa L, Uribe-Zúñiga P, et al. Seroprevalencias a diversos virus y características sociodemográficas en mujeres que buscan detectarse VIH. Rev Invest Clin 1997;49:5–13
Juárez-Figueroa L, Uribe-Salas F, Conde-González C, Hernández-Ávila M, Olamendi-Portugal M, Uribe-Zúñiga P, et al. Low prevalence of hepatitis B among Mexican female sex workers. Sex Transm Infect 1998;74:448–450
Uribe-Salas F, Hernández-Avila , Juárez-Figueroa L, Conde-González CJ, Uribe-Zuñiga P. Risk factors for herpes simplex virus type 2 infection among female commercial sex workers in Mexico City. Int J STD AIDS 1999;10(2):105–111. doi:10.1258/0956462991913727
Uribe-Salas F, Conde-González CJ, Juárez-Figueroa L, Hernández-Castellanos A. Sociodemographic dynamics and sexually transmitted infections in female sex workers at the Mexican-Guatemalan border. Sex Transm Dis 2003;30(3):266–271. doi:10.1097/00007435-200303000-00018
Tamez Treviño E, Tijerina Menchaca R, Bosques Padilla F, Rangel Orozco R, Isibasi A, Flores Castañeda MS. Frecuencia de la infección con VHC, VHB o VIH no diagnosticada en pacientes hepatópatas. Med Universitaria 2002;4(16):148–152
Campollo O, Valencia-Salinas JJ, Berumen-Arellano A, Pérez-Aranda MA, Panduro-Cerda A, Segura-Ortega J. Características epidemiológicas de la cirrosis hepática en el Hospital Civil de Guadalajara. Salud Publica Mex 1997;39:195–200. doi:10.1590/S0036-36341997000300004
Porras Nuñez LO, Balderas Ávila R, Lejia Guzman M, Mattar Olivo C. Core M marcador útil de hepatitis B en pacientes de hemodiálisis. Rev Mex Patol Clin 2002;49(3):148–152
Treviño Hernández R, Pérez Ramírez JL, Cruz Valdez J, Ramírez B, et al. Prevalencia de hepatitis C y B en pacientes con insuficiencia renal crónica en programa de hemodiálisis en el Hospital Universitario y Centro Renal de Monterrey. Med Universitaria 2003;5(21):228–232
Kato-Maeda M, Ponce-de-Leon S, Sifuentes-Osoirnio J, Rangel-Frausto MS, Calva-Mercado J, Infante-Surez L, et al. Bloodborne viral infections in patients attending an emergency room in Mexico City: estimate of seroconversion probability in healthcare workers alter an occupational exposure. Infect Control Hosp Epidemiol 2000;21(9):600–602. doi:10.1086/501811
Alvarado-Esquivel C, Arreola-Valenzuela MA, Mercado-Suarez F, Espinoza-Andrade F. Hepatitis B virus infection among inpatients of a psychiatric hospital of Mexico. Clin Pract Epidemol Ment Health 2005;1:10. doi:10.1186/1745-0179-1-10
Alvarez Muñoz MT, Bustamante Calvillo MA, Martínez García MC, Moreno Altamirano L, Guiscafre-Gallardo H, Guiscafre JP, et al. Seroepidemiology of the hepatitis B and delta in the southeast of Chiapas, Mexico. Arch Invest Med (Mex) 1989;20(2):189–195
Cisneros-Castolo M, Hernández-Ruiz L, Ibarra-Robles IE, Fernández-Gárate IH, Escobedo-de la Peña J. Prevalence of hepatitis B virus infection and related risk factors in a rural community of Mexico. Am J Trop Med Hyg 2001;65(6):759–763
Roman S, Panduro A, Maldonado M, Sanchez C, Quezada D, Martinez E, et al. High prevalence of occult hepatitis B infection among different Mexican ethnic groups. Liver Int 2006;26(Suppl 1):S51
Secretaria de Salud. México, Sistema Único de Vigilancia Epidemiológica. Dirección General de Epidemiología. Anuario de Morbilidad 1984–2006 [cited December 2007]. Available from: http://www.dgepi.salud.gob.mx/anuario/mdex.html
Secretaria de Salud. México, Sistema Nacional de Información en Salud, Reporte de Mortalidad 2000–2005 [cited December 2007]. Available from: http://sinais.salud.gob.mx/mortalidad
Instituto Nacional de Estadisticas. Geografia e Informatica (INEGI). Censo General de Población y Vivienda 2000 (data on CD-ROM). Aguascalientes (Mexico): INEGI; 2001
Celis A, Gaxiola-Robles R, Sevilla-Godinez E, Orozco-Valerio MJ, Armas J. Tendencia de la mortalidad por picaduras de alacran en Mexico, 1979–2003. Rev Panam Salud Publica 2007;21(6):373–380. doi:10.1590/S1020-49892007000500005
Taylor RN, Fulford KM. Results of the Center for Disease Control Proficiency Testing Program for the detection of hepatitis B surface antigen. J Clin Microbiol 1976;4(1):32–39
Weber B, Bayer A, Kirch P, Schlüter V, Schlieper D, Melchior W. Improved detection of hepatitis B virus surface antigen by a new rapid automated assay. J Clin Microbiol 1999;37(8):2639–2647
Diepersloot RJ, van Zantvliet-van Oostrom Y, Gleaves CA. Comparison of a chemiluminescent immunoassay with two microparticle enzyme immunoassays for detection of hepatitis B virus surface antigen. Clin Diagn Lab Immunol 2000;7(6):865–866. doi:10.1128/CDLI.7.6.865-866.2000
Gerlich WH. Diagnostic problems caused by HBsAg mutants—a consensus report of an expert meeting. Intervirology 2004;47(6):310–313. doi:10.1159/000080873
Ly TD, Servant-Delmas A, Bagot S, Gonzalo S, Férey MP, Ebel A, et al. Sensitivities of four new commercial hepatitis B virus surface antigen (HBsAg) assays in detection of HBsAg mutant forms. J Clin Microbiol 2006;44(7):2321–2326. doi:10.1128/JCM.00121-06
Food and Drug Administration. Test for hepatitis B surface antigen. Fed Regist 1975;40:P29706–P29712
Principles in evaluation of HBsAg test kits: appropriate use of 2nd WHO International Standard (IS) and Reference Panel for HBsAg. Geneva: World Health Organization; Nov 2004 [cited September 15, 2008]. Available from: http://www.who.int/entity/bloodproducts/publications/en/HBsAg_application_ECBS_2004pdf
Mizuochi T, Okada Y, Umemori K, Mizusawa S, Sato S, Yamaguchi K. Reactivity of genotypically distinct hepatitis B virus surface antigens in 10 commercial diagnostic kits available in Japan. Jpn J Infect Dis 2005;58(2):83–87
van Roosmalen MH, de Jong JJ, Haenen W, Jacobs T, Couwenberg F, Ahlers-de Boer GJ, et al. A new HBsAg screening assay designed for sensitive detection of HBsAg subtypes and variants. Intervirology 2006;49(3):127–132. doi:10.1159/000089373
Togashi H, Hashimoto C, Yokozawa J, Suzuki A, Sugahara K, Saito T, et al. What can be revealed by extending the sensitivity of HBsAg detection to below the present limit? J Hepatol 2008;49(1):17–24. doi:10.1016/j.jhep.2008.03.019
Baptista González HA, Kourchenko Raab H, Rosenfeld Mann F, Rizo Almenara S, Peñuela Olaya MA. Estudio de infecciones virales en el lactante menor transfundido en la etapa neonatal. Bol Med Hosp Infant Mex 1998;55(7):386–392
Cervantes Bustamante R, Ramírez Mayans J, Zarate Mondragón F, Mata Rivera N, Munguia Venegas P, Mason Cordero T, et al. Marcadores serológicos para el virus de Hepatitis B en un grupo de niños mexicanos. Acta Pediatr Mex 2002;23(6):352–354
Norma Oficial Mexicana NOM. 003/SSA2/1993. Normas y Técnicas para la Disposición de Sangre Humana y sus Componentes con Fines Terapéuticos. Diario Oficial de la Federación del 18 de Julio del 1994 [cited November 2007]. Available from: http://www.salud.gob.mx/unidades/cdi/nom/003ssa23.html
Norma Oficial Mexicana. NOM-031-SSA2-1999, para la atencion a la salud del niňo. Diario Oficial de Federacion del 9 de junio del 2000 [cited November 2007]. Available from: http://www.salud.gob.mx/unidades/cdi/nom/031ssa29.html
CONADICT. Statistics on Drug Abuse Patterns, Mexico 2001 [cited January 2008]. Available from: http://www.conadic.gob.mx/pre/ena2002.html
Simonetti RG, Camma C, Fiorello F, Politi F, D’amico G, Pagliaro L. Hepatocellular carcinoma. A worldwide problem and the major risk factors. Dig Dis Sci 1991;36:962–972. doi:10.1007/BF01297149
Tanaka Y, Kurbanov F, Mano S, Orito E, Vargas V, Esteban JI, et al. Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma. Gastroenterology 2006;130(3):703–714. doi:10.1053/j.gastro.2006.01.032