A large-scale genome-wide association study meta-analysis of cannabis use disorder

The Lancet Psychiatry - Tập 7 Số 12 - Trang 1032-1045 - 2020
Emma C. Johnson1, Ditte Demontis2,3,4, Thorgeir E. Thorgeirsson5, Raymond K. Walters6,7, Renato Polimanti8,9, Alexander S. Hatoum1, Sandra Sanchez‐Roige10,11, Sarah E. Paul12, Frank R. Wendt8,9, Toni‐Kim Clarke13, Dongbing Lai14, Gunnar W. Reginsson5, Hang Zhou8,9, June He1, David A. A. Baranger15, Daníel F. Guðbjartsson16,17, Robbee Wedow6,7, Daniel E. Adkins18,19,20, Amy Adkins18,19,20, Jeffry Alexander21, Silviu‐Alin Bacanu21, Tim B. Bigdeli22, Joseph M. Boden23, Sandra A. Brown11,24, Kathleen K. Bucholz1, Jonas Bybjerg‐Grauholm25,4, Robin P. Corley26, Louisa Degenhardt27, Danielle M. Dick28,20, Benjamin W. Domingue29, Louis Fox1, Alison Goate30, Scott D. Gordon31, Laura M. Hack32, Dana B. Hancock33, Sarah M. Hartz1, Ian B. Hickie34, David M. Hougaard25,4, Kenneth Krauter35,36, Penelope A. Lind31, Jeanette N. McClintick37, Matthew B. McQueen38, Jacquelyn L. Meyers22,39, Grant W. Montgomery40, Ole Mors41,4, Preben Bo Mortensen42,43,4, Merete Nordentoft44,4, John F. Pearson45,46, Roseann E. Peterson47, Maureen Reynolds48, John P. Rice1, Valgerður Rúnarsdóttir49, Nancy L. Saccone50,51, Richard Sherva52, Judy L. Silberg28,47, Ralph E. Tarter48, Þórarinn Tyrfingsson49, Tamara L. Wall11, Bradley T. Webb21, Thomas Werge53,54,4, Leah Wetherill14, Margaret J. Wright55, Stephanie Zellers56, Mark J. Adams13, Laura J. Bierut1, Jason D. Boardman57, William Copeland58, Lindsay A. Farrer52, Tatiana Foroud14, Nathan A. Gillespie47, Richard A. Grucza1, Kathleen Mullan Harris59, Andrew C. Heath1, Victor Hesselbrock60, John K. Hewitt26, Christian J. Hopfer61, L. John Horwood23, William G. Iacono56, Eric O. Johnson33, Kenneth S. Kendler47, Martin A. Kennedy46, Henry R. Kranzler62,63, Pamela A. F. Madden1, Hermine H. Maes28,47, Brion S. Maher64, Nicholas G. Martin31, Matthew McGue56, Andrew M. McIntosh13, Sarah E. Medland31, Elliot C. Nelson1, Bernice Porjesz22,39, Brien P. Riley21, Michael C. Stallings26, Michael M. Vanyukov48, Scott Vrieze56, Lea K. Davis10,65, Ryan Bogdan12, Joel Gelernter66,8,9, Howard J. Edenberg37,14, Kāri Stefánsson67,68, Anders D. Børglum2,3,4, Arpana Agrawal1, Emma Johnson1, Fazil Alıev, Anthony Batzler, Sarah Bertelsen31, Joanna M. Biernacka, Li‐Shiun Chen, Yi‐Ling Chou, Franziska Degenhardt27, Anna R. Docherty, Alexis C. Edwards, Pierre Fontanillas, Jerome C. Foo, Josef Frank8,9, Ina Giegling, Annette M. Hartmann, Stefanie Heilmann‐Heimbach, Stefan Herms67,68, Colin A. Hodgkinson, Per Hoffman, Jouke‐Jan Hottenga, Mervi Alanne-Kinnunen, Bettina Konte, Jari Lahti, Marius Lahti‐Pulkkinen, Lannie Ligthart, Anu Loukola21, Hamdi Mbarek, Yuri Milaneschi, Teemu Palviainen, Samuli Ripatti, Euijung Ryu, Jessica E. Salvatore, Melanie L. Schwandt, Fabian Streit, Jana Strohmaier, Nathaniel Thomas53,54,4, Jen‐Chyong Wang, Amanda G. Wills, Danfeng Chen, Doo‐Sup Choi, Robert Culverhouse, Norbert Dahmen, Sarah L. Elson1, Mark A. Frye13, Wolfgang Gäbel, Caroline Hayward, Marcus Ising, Margaret A. Keyes55, Falk Kiefer, John R. Kramer33, Samuel Kuperman, Susanne Lucae, Michael T. Lynskey48, Wolfgang Maier, Karl Mann, Satu Männistö, Bertram Müller‐Myhsok, Alison D. Murray30, John I. Nürnberger33, Aarno Palotie, Ulrich W. Preuss, Katri Räikkönen, Monika Ridinger, Norbert Scherbaum, Marc A. Schuckit, Michael Soyka48, Jens Treutlein, Stephanie H. Witt26, Norbert Wodarz, Peter Zill47, Dorret I. Boomsma, Sven Cichon, E. Jane Costello, Harriet de Wit, Nancy Diazgranados50,51, Johan G. Eriksson, Nathan Gillespie47, David Goldman25,4, Jaakko Kaprio, Victor M. Karpyak60, Paul Lichtenstein12, Matt McGue56, James MacKillop, Patrik K. E. Magnusson, Markus M. Nöthen, Abraham A. Palmer, Nancy Pederson50,51, Brenda W.J.H. Penninx, John Rice1, Marcella Rietschel, Richard J. Rose47, Dan Rujescu12, Pei‐Hong Shen, John B. Whitfield33, Hongyu Zhao, Benjamin M. Neale29
1Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
2Center for Genomics and Personalized Medicine, Aarhus, Denmark
3Department of Biomedicine—Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark
4The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark
5CNS Department, Reykjavik, Iceland
6Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
7Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
8Division of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
9Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA
10Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
11Department of Psychiatry, University of California, San Diego, La Jolla, CA USA
12Department of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA
13Division of Psychiatry, University of Edinburgh, Edinburgh, UK
14Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN USA
15Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
16School of Engineering and Natural Sciences, Iceland University, Reykjavik, Iceland
17Statistics Department, Reykjavik, Iceland
18College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA
19Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
20Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
21Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, VA, USA
22Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA
23Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
24Department of Psychology and Office of Research Affairs, University of California San Diego, La Jolla, CA, USA
25Department for Congenital Disorders, Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark
26Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA
27National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia
28Department of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
29Stanford University Graduate School of Education, Stanford University, Stanford, CA, USA
30Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
31QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
32Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
33GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, Durham, NC, USA
34Brain and Mind Centre, University of Sydney, Sydney, Australia
35Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA
36University of Colorado Boulder, Boulder, CO, USA
37Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN USA
38Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
39Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Health Sciences University, Brooklyn, NY, USA
40Institute for Molecular Bioscience, University of Queensland, QLD, Australia
41Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark
42Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark
43National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark
44Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
45Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand
46Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand
47Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
48School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
49SAA—National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland
50Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
51Division of Biostatistics, Washington University School of Medicine, St. Louis, Mo. USA
52Department of Medicine, Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA
53Department of Clinical Medicine, and Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark
54Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark
55Queensland Brain Institute, University of Queensland, QLD, Australia
56Department of Psychology, University of Minnesota, Minneapolis, MN USA
57Institute of Behavioral Science and Department of Sociology, University of Colorado Boulder, Boulder, CO, USA
58Department of Psychiatry, University of Vermont Medical Center, Burlington, VT, USA
59Department of Sociology, and The Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
60Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT USA.
61Department of Psychiatry, University of Colorado Denver, Aurora, CO, USA
62Center for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
63VISN 4 MIRECC, Crescenz VAMC, Philadelphia, PA, USA
64Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
65Department of Psychiatry and Behavioral Sciences, and Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
66Department of Genetics, and Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA
67Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
68deCODE Genetics/Amgen, Reykjavik, Iceland

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The Lancet Psychiatry

Tập 7 Số 12

1032-1045

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