A human monoclonal anti-TNF alpha antibody (adalimumab) reduces airway inflammation and ameliorates lung histology in a murine model of acute asthma

(GINA) 2011. Available from: http://www.ginasthma.org Hogg, 1993, Pathology of asthma, J Allergy Clin Immunol, 92, 1, 10.1016/0091-6749(93)90029-F Lukacs, 1995, TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation, J Immunol, 154, 5411, 10.4049/jimmunol.154.10.5411 Hybertson, 1997, TNF mediates lung leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally, Am J Respir Crit Care Med, 155, 1972, 10.1164/ajrccm.155.6.9196104 Scheurich, 1987, Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNFalpha-mediated enhancement of T cell responses, J Immunol, 138, 1786, 10.4049/jimmunol.138.6.1786 Casale, 1996, TNF alpha is important in human lung allergic reactions, Am J Respir Cell Mol Biol, 15, 35, 10.1165/ajrcmb.15.1.8679220 Hutchison, 2008, Tumour necrosis factor-alpha blockade suppresses murine allergic airways inflammation, Clin Exp Immunol, 151, 114, 10.1111/j.1365-2249.2007.03509.x Kim, 2006, Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust, Clin Exp Allergy, 36, 122, 10.1111/j.1365-2222.2005.02407.x Fisher, 2005, FITC-induced murine pulmonary inflammation: CC10 up-regulation and concurrent Shh expression, Cell Biol Int, 29, 868, 10.1016/j.cellbi.2005.07.002 Walker, 2003, Beta-arrestin-2 regulates the development of allergic asthma, J Clin Invest, 112, 566, 10.1172/JCI200317265 Teran, 1999, Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts, Am J Respir Cell Mol Biol, 20, 777, 10.1165/ajrcmb.20.4.3508 Garcia-Zepeda, 1996, Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3, J Immunol, 157, 5613, 10.4049/jimmunol.157.12.5613 Bradding, 1994, Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the humanmast cell as a source of these cytokines, Am J Respir Cell Mol Biol, 10, 471, 10.1165/ajrcmb.10.5.8179909 Schwingshackl, 1999, Human eosinophils release matrix metalloproteinase-9 on stimulation with TNF alpha, J Allergy Clin Immunol, 104, 983, 10.1016/S0091-6749(99)70079-5 Howarth, 2005, Tumour necrosis factor (TNF alpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma, Thorax, 60, 1012, 10.1136/thx.2005.045260 Hanauer, 2006, Human antitumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial, Gastroenterology, 130, 323, 10.1053/j.gastro.2005.11.030 Zuany-Amorim, 1995, Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice, J Clin Invest, 95, 2644, 10.1172/JCI117966 Renzetti, 1996, Pharmacological evidence for tumor necrosis factor as a mediator of allergic inflammation in the airways, J Pharmacol Exp Ther, 278, 847 Elliott, 1993, Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha, Arthritis Rheum, 36, 1681, 10.1002/art.1780361206 Rudmann, 2000, Modulation of allergic inflammation in mice deficient in TNF receptors, Am J Physiol-Lung Cell Mol Physiol, 279, 1047, 10.1152/ajplung.2000.279.6.L1047 Hessel, 1997, Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration, Am J Respir Cell Mol Biol, 16, 325, 10.1165/ajrcmb.16.3.9070618 Nam, 2009, The soluble tumor necrosis factor-alpha receptor suppresses airway inflammation in a murine model of acute asthma, Yonsei Med J, 50, 569, 10.3349/ymj.2009.50.4.569 Feldman, 1998, Anti-TNF alpha therapy is useful in rheumatoid arthritis and Crohn's disease: analysis of the mechanism of action predicts utility in other diseases, Transplant Proc, 30, 4126, 10.1016/S0041-1345(98)01365-7 Berry, 2006, Evidence of a role of tumor necrosis factor alpha in refractory asthma, N Engl J Med, 354, 697, 10.1056/NEJMoa050580