A high content screening assay to predict human drug-induced liver injury during drug discovery

Abraham, 2008, Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans, Journal of Biomolecular Screening, 13, 527, 10.1177/1087057108318428 Arrowsmith, 2011, Trial watch: Phase II failures: 2008–2010, Nature Reviews. Drug Discovery, 10, 328, 10.1038/nrd3439 Arrowsmith, 2011, Trial watch: phase III and submission failures: 2007–2010, Nature Reviews. Drug Discovery, 10, 87, 10.1038/nrd3375 Begriche, 2011, Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver, Journal of Hepatology, 54, 773, 10.1016/j.jhep.2010.11.006 Benbow, 2010, Predicting safety toleration of pharmaceutical chemical leads: Cytotoxicity correlations to exploratory toxicity studies, Toxicology Letters, 197, 175, 10.1016/j.toxlet.2010.05.016 Blas-Garcia, 2010, Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells, Hepatology, 52, 115, 10.1002/hep.23647 Boelsterli, 2007, Mitochondrial abnormalities — A link to idiosyncratic drug hepatotoxicity?, Toxicology and Applied Pharmacology, 220, 92, 10.1016/j.taap.2006.12.013 Chalasani, 2010, Risk factors for idiosyncratic drug-induced liver injury, Gastroenterology, 138, 2246, 10.1053/j.gastro.2010.04.001 Chan, 2005, Drug-induced mitochondrial toxicity, Expert Opinion on Drug Metabolism & Toxicology, 1, 655, 10.1517/17425255.1.4.655 Czaja, 2011, Functions of autophagy in hepatic and pancreatic physiology and disease, Gastroenterology, 140, 1895, 10.1053/j.gastro.2011.04.038 Dawson, 2012, In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans, Drug Metabolism and Disposition, 40, 130, 10.1124/dmd.111.040758 Dykens, 2007, Strategies to reduce late-stage drug attrition due to mitochondrial toxicity, Expert Review of Molecular Diagnostics, 7, 161, 10.1586/14737159.7.2.161 Dykens, 2007, The significance of mitochondrial toxicity testing in drug development, Drug Discovery Today, 12, 777, 10.1016/j.drudis.2007.07.013 Fung, 2001, Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceutical markets — 1960 to 1999, Drug Information Journal, 35, 293, 10.1177/009286150103500134 Greer, 2010, Cell based approaches for evaluation of drug-induced liver injury, Toxicology, 268, 125, 10.1016/j.tox.2009.08.007 Holt, 2006, Mechanisms of drug-induced liver injury, The AAPS Journal, 8, E48, 10.1208/aapsj080106 Homberg, 1982, A new antimitochondria antibody (anti-M6) in iproniazid-induced hepatitis, Clinical and Experimental Immunology, 47, 93 Kaplowitz, 2004, Drug-induced liver injury, Clinical Infectious Diseases, 38, S44, 10.1086/381446 Kaplowitz, 2005, Idiosyncratic drug hepatotoxicity, Nature Reviews. Drug Discovery, 4, 489, 10.1038/nrd1750 Kola, 2004, Can the pharmaceutical industry reduce attrition rates?, Nature Reviews. Drug Discovery, 3, 711, 10.1038/nrd1470 Labbe, 2008, Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies, Fundamental and Clinical Pharmacology, 22, 335, 10.1111/j.1472-8206.2008.00608.x Lammert, 2008, Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals, Hepatology, 47, 2003, 10.1002/hep.22272 Lee, 2003, Drug-induced hepatotoxicity, The New England Journal of Medicine, 349, 474, 10.1056/NEJMra021844 Lin, 2011, Evaluation of drugs with specific organ toxicities in organ specific cell lines, Toxicological Sciences, 126, 114, 10.1093/toxsci/kfr339 Muller, 2012, The determination and interpretation of the therapeutic index in drug development, Nature Reviews. Drug Discovery, 11, 751, 10.1038/nrd3801 Nadanaciva, 2011, A high content screening assay for identifying lysosomotropic compounds, Toxicology In Vitro, 25, 715, 10.1016/j.tiv.2010.12.010 Nakayama, 2009, A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding, Drug Metabolism and Disposition, 37, 1970, 10.1124/dmd.109.027797 O'Brien, 2006, High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening, Archives of Toxicology, 80, 580, 10.1007/s00204-006-0091-3 Olson, 2000, Concordance of the toxicity of pharmaceuticals in humans and in animals, Regulatory Toxicology and Pharmacology, 32, 56, 10.1006/rtph.2000.1399 Otto, 2008, Development of an in vitro assay for the investigation of metabolism-induced drug hepatotoxicity, Cell Biology and Toxicology, 24, 87, 10.1007/s10565-007-9018-x Pessayre, 2012, Central role of mitochondria in drug-induced liver injury, Drug Metabolism Reviews, 44, 34, 10.3109/03602532.2011.604086 Pons, 1996, Human anti-mitochondria autoantibodies appearing in iproniazid-induced immunoallergic hepatitis recognize human liver monoamine oxidase B, Biochemical and Biophysical Research Communications, 218, 118, 10.1006/bbrc.1996.0021 Russmann, 2009, Current concepts of mechanisms in drug-induced hepatotoxicity, Current Medicinal Chemistry, 16, 3041, 10.2174/092986709788803097 Schneider, 1997, A review of drug-induced lysosomal disorders of the liver in man and laboratory animals, Microscopy Research and Technique, 36, 253, 10.1002/(SICI)1097-0029(19970215)36:4<253::AID-JEMT4>3.0.CO;2-N Stepan, 2011, Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: A perspective based on the critical examination of trends in the top 200 drugs marketed in the United States, Chemical Research in Toxicology, 24, 1345, 10.1021/tx200168d Stevens, 2009, The future of drug safety testing: Expanding the view and narrowing the focus, Drug Discovery Today, 14, 162, 10.1016/j.drudis.2008.11.009 Thompson, 2012, In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs, Chemical Research in Toxicology, 25, 1616, 10.1021/tx300091x Xu, 2008, Cellular imaging predictions of clinical drug-induced liver injury, Toxicological Sciences, 105, 97, 10.1093/toxsci/kfn109 Zhang, 2008, Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives, Biomedicine and Pharmacotherapy, 62, 65, 10.1016/j.biopha.2007.04.007