A healthy mind in a healthy body: Effects of arteriosclerosis and other risk factors on cognitive aging and dementia

Psychology of Learning and Motivation - Tập 77 - Trang 69-123 - 2022
Monica Fabiani1,2, Bethlehem A. Asnakew1,2, Daniel C. Bowie1,2, Sydney M. Chism1,2, Grace M. Clements1,2, Jennie C. Gardner1,2, Samia S. Islam1,2, Samantha L. Rubenstein1,2, Gabriele Gratton1,2
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL, United States
2Psychology Department, University of Illinois at Urbana-Champaign, Champaign, IL, United States

Tài liệu tham khảo

Akazawa, 2020, Association between mental health and arterial stiffness in middle-aged and older adults, Artery Research, 26, 223, 10.2991/artres.k.200720.001 Akazawa, 2020, The impact of aerobic fitness on arterial stiffness and adrenal cortex hormones in middle-aged and older adults, Endocrine Journal, 67, 1199, 10.1507/endocrj.EJ20-0211 Anderson, 2018, Memory rehabilitation in healthy aging, Oxford Research Encyclopedia of Psychology., 10.1093/acrefore/9780190236557.013.447 Baddeley, 1992, Working memory, Science, 255, 556, 10.1126/science.1736359 Badji, 2019, Arterial stiffness and white matter integrity in the elderly: A diffusion tensor and magnetization transfer imaging study, NeuroImage, 186, 577, 10.1016/j.neuroimage.2018.11.015 Badji, 2020, Cerebrovascular pathology in Alzheimer's disease: Hopes and gaps, Psychiatry Research: Neuroimaging, 306 Bakker, 2008, Pattern separation in the human hippocampal CA3 and dentate gyrus, Science, 319, 1640, 10.1126/science.1152882 Baltes, 1988, On the range of cognitive plasticity in old age as a function of experience: 15 Years of intervention research, Behavior Therapy, 19, 283, 10.1016/S0005-7894(88)80003-0 Baltes, 1997, Emergence of a powerful connection between sensory and cognitive functions across the adult life span: A new window to the study of cognitive aging?, Psychology and Aging, 12, 12, 10.1037/0882-7974.12.1.12 Bangen, 2021, Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia, Alzheimer's Research & Therapy, 13, 1, 10.1186/s13195-021-00851-2 Banich, 2009, Executive function: The search for an integrated account, Current Directions in Psychological Science, 18, 89, 10.1111/j.1467-8721.2009.01615.x Barnes, 2015, Exercise, cognitive function, and aging, Advances in Physiology Education, 39, 55, 10.1152/advan.00101.2014 Barnes, 2018, Exercise improves vascular function, but does this translate to the brain?, Brain Plasticity, 4, 65, 10.3233/BPL-180075 Barnes, 2011, O3-06-06: The projected impact of risk factor reduction on Alzheimer's disease prevalence, Alzheimer's & Dementia, 7, S511, 10.1016/j.jalz.2011.05.1429 Benear, 2020, Dissecting the fornix in basic memory processes and neuropsychiatric disease: A review, Brain Connectivity, 10, 331, 10.1089/brain.2020.0749 Benveniste, 2019, The glymphatic system and waste clearance with brain aging: A review, Gerontology, 65, 106, 10.1159/000490349 Bhattacharyya, 2021, Gut-Brain axis in Parkinson's disease etiology: The role of lipopolysaccharide, Chemistry and Physics of Lipids, 235, 105029, 10.1016/j.chemphyslip.2020.105029 Bos, 2011, Calcification in major vessel beds relates to vascular brain disease, Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 2331, 10.1161/ATVBAHA.111.232728 Botvinick, 2001, Conflict monitoring and cognitive control, Psychological Review, 108, 624, 10.1037/0033-295X.108.3.624 Bowie, 2021, Chapter 36. The effects of cardiorespiratory fitness on brain and cognitive aging, 415 Braver, 2012, The variable nature of cognitive control: A dual mechanisms framework, Trends in Cognitive Sciences, 16, 106, 10.1016/j.tics.2011.12.010 Braver, 2002, A theory of cognitive control, aging cognition, and neuromodulation, Neuroscience & Biobehavioral Reviews, 26, 809, 10.1016/S0149-7634(02)00067-2 Braver, 2003, Neural mechanisms of transient and sustained cognitive control during task switching, Cell Press, 39, 713 Brown, 1981, Gene expression in eukaryotes, Science, 211, 667, 10.1126/science.6256857 Brown, 2011, Review: Cerebral microvascular pathology in ageing and neurodegeneration, Neuropathology and Applied Neurobiology., 37, 56, 10.1111/j.1365-2990.2010.01139.x Brumback, 2005, Putting things into perspective: Individual differences in working-memory span and the integration of information, Experimental Psychology, 52, 21, 10.1027/1618-3169.52.1.21 Buckner, 2004, Memory and executive function in aging and AD: Multiple factors that cause decline and reserve factors that compensate, Neuron, 44, 195, 10.1016/j.neuron.2004.09.006 Bugg, 2006, Age differences in fluid intelligence: Contributions of general slowing and frontal decline, Brain and Cognition, 62, 9, 10.1016/j.bandc.2006.02.006 Cabeza, 1997, Age-related differences in neural activity during memory encoding and retrieval: A positron emission tomography study, Journal of Neuroscience, 17, 391, 10.1523/JNEUROSCI.17-01-00391.1997 Cambronero, 2018, APOE genotype modifies the association between central arterial stiffening and cognition in older adults, Neurobiology of Aging, 67, 120, 10.1016/j.neurobiolaging.2018.02.009 Camina, 2017, The neuroanatomical, neurophysiological and psychological basis of memory: Current models and their origins, Frontiers in Pharmacology, 8, 438, 10.3389/fphar.2017.00438 Campbell, 2012, Age differences in the frontoparietal cognitive control network: Implications for distractibility, Neuropsychologia, 50, 2212, 10.1016/j.neuropsychologia.2012.05.025 Carmona, 2018, The genetic landscape of Alzheimer disease, Handbook of Clinical Neurology, 148, 395, 10.1016/B978-0-444-64076-5.00026-0 Carpenter, 1990, What one intelligence test measures: A theoretical account of the processing in the Raven progressive matrices test, Psychological Review, 97, 404, 10.1037/0033-295X.97.3.404 Carr, 2017, Individual differences in associative memory among older adults explained by hippocampal subfield structure and function, Proceedings of the National Academy of Sciences, 114, 12075, 10.1073/pnas.1713308114 Casserly, 2004, Convergence of atherosclerosis and Alzheimer's disease: Inflammation, cholesterol, and misfolded proteins, The Lancet, 363, 1139, 10.1016/S0140-6736(04)15900-X Cecelja, 2016, Molecular mechanisms of arterial stiffening, Pulse, 4, 43, 10.1159/000446399 Chen, 2011, Age-related alterations in the modular organization of structural cortical network by using cortical thickness from MRI, Neuroimage, 56, 235, 10.1016/j.neuroimage.2011.01.010 Chiarelli, 2017, Individual differences in regional cortical volumes across the life span are associated with regional optical measures of arterial elasticity, NeuroImage, 162, 199, 10.1016/j.neuroimage.2017.08.064 Chini, 2021, Prefrontal cortex development in health and disease: Lessons from rodents and humans, Trends in Neurosciences, 44, 227, 10.1016/j.tins.2020.10.017 Cohen, 1993 Cohen, 2014, Early detection of Alzheimer's disease using PiB and FDG PET, Neurobiology of Disease, 72, 117, 10.1016/j.nbd.2014.05.001 Cohen, 1997, Memory for items and memory for relations in the procedural/declarative memory framework, Memory, 5, 131, 10.1080/741941149 Cohen, 1999, Hippocampal system and declarative (relational) memory: Summarizing the data from functional neuroimaging studies, Hippocampus, 9, 83, 10.1002/(SICI)1098-1063(1999)9:1<83::AID-HIPO9>3.0.CO;2-7 Colcombe, 2003, Fitness effects on the cognitive function of older adults: A meta-analytic study, Psychological Science, 14, 125, 10.1111/1467-9280.t01-1-01430 Colcombe, 2004, Cardiovascular fitness, cortical plasticity, and aging, Proceedings of the National Academy of Sciences, 101, 3316, 10.1073/pnas.0400266101 Corder, 1993, Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, Science, 261, 921, 10.1126/science.8346443 Cowan, 2001, The magical number 4 in short-term memory: A reconsideration of mental storage capacity, Behavioral and Brain Sciences, 24, 87, 10.1017/S0140525X01003922 Cowan, 2010, The magical mystery four: How is working memory capacity limited, and why?, Current Directions in Psychological Science, 19, 51, 10.1177/0963721409359277 Craik, 1994, Memory changes in normal aging, Current Directions in Psychological Science, 5, 155, 10.1111/1467-8721.ep10770653 Dai, 2012, Cardiac aging: From molecular mechanisms to significance in human health and disease, Antioxidants & Redox Signaling, 16, 1492, 10.1089/ars.2011.4179 Daniels, 2006, The aging of executive functions, 96 Darst, 2017, Pathway-specific polygenic risk scores as predictors of amyloid-β deposition and cognitive function in a sample at increased risk for Alzheimer's disease, Journal of Alzheimer's Disease, 55, 473, 10.3233/JAD-160195 Davenport, 2012, Cerebrovascular reserve: The link between fitness and cognitive function?, Exercise and Sport Sciences Reviews, 40, 153, 10.1097/JES.0b013e3182553430 de Almeida, 2020, Unveiling the role of inflammation and oxidative stress on age-related cardiovascular diseases, Oxidative Medicine and Cellular Longevity, 2020, 20, 10.1155/2020/1954398 de Bruijn, 2014, Cardiovascular risk factors and future risk of Alzheimer's disease, BMC Medicine, 12, 130, 10.1186/s12916-014-0130-5 de la Torre, 2012, Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia, Cardiovasc Psychiatry Neurology, 2012, 10.1155/2012/367516 Demer, 2008, Vascular calcification, Circulation, 117, 2938, 10.1161/CIRCULATIONAHA.107.743161 Dempster, 2021, Linking the hemodynamic consequences of adverse childhood experiences to an altered HPA axis and acute stress response, Brain, Behavior, and Immunity, 93, 254, 10.1016/j.bbi.2020.12.018 Dengo, 2010, Arterial destiffening with weight loss in overweight and obese middle-aged and older adults, Hypertension, 55, 855, 10.1161/HYPERTENSIONAHA.109.147850 D’Esposito, 2000, Prefrontal cortical contributions to working memory: Evidence from event-related fMRI studies DeTure, 2019, The neuropathological diagnosis of Alzheimer's disease, Molecular Neurodegeneration, 14, 32, 10.1186/s13024-019-0333-5 De Wit, 2022, Declarative learning, priming, and procedural learning performances comparing individuals with amnestic mild cognitive impairment, and cognitively unimpaired older adults, Journal of the International Neuropsychological Society, 1, 10.1017/S1355617722000029 Dickerson, 2017, Approach to atypical Alzheimer's disease and case studies of the major subtypes, CNS Spectrums, 22, 439, 10.1017/S109285291600047X Dougherty, 2021, Cardiorespiratory fitness mitigates brain atrophy and cognitive decline in adults at risk for Alzheimer's disease, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 13 Duncan, 2014, Associative encoding and retrieval are predicted by functional connectivity in distinct hippocampal area CA1 pathways, Journal of Neuroscience, 34, 11188, 10.1523/JNEUROSCI.0521-14.2014 Durier, 2003, Physiological genomics of human arteries, Circulation, 108, 1845, 10.1161/01.CIR.0000091407.86925.7A Duyckaerts, 2009, Classification and basic pathology of Alzheimer disease, Acta Neuropathologica, 118, 5, 10.1007/s00401-009-0532-1 Edelman, 2019, Noncontrast MR angiography: An update, Journal of Magnetic Resonance Imaging, 49, 355, 10.1002/jmri.26288 Edenfield, 2011, Exercise and stress reduction, 301 Eichenbaum, 2007, The medial temporal lobe and recognition memory, Annual Reviews of Neuroscience, 30, 123, 10.1146/annurev.neuro.30.051606.094328 Engle, 2001, What is working memory capacity?, 297 Engle, 2002, Working memory capacity as executive attention, Current Directions in Psychological Science, 11, 19, 10.1111/1467-8721.00160 Erickson, 2011, Exercise training increases size of hippocampus and improves memory, Proceedings of the National Academy of Science, 108, 3017, 10.1073/pnas.1015950108 Esch, 2010, Endogenous reward mechanisms and their importance in stress reduction, exercise and the brain, Archives of Medical Science: AMS, 6, 447, 10.5114/aoms.2010.14269 Fabiani, 2012, It was the best of times, it was the worst of times: A psychophysiologist's view of cognitive aging, Psychophysiology, 49, 283, 10.1111/j.1469-8986.2011.01331.x Fabiani, 1995, Changes in brain activity patterns in aging: The novelty oddball, Psychophysiology, 32, 579, 10.1111/j.1469-8986.1995.tb01234.x Fabiani, 1997, Dissociations between memory for temporal order and recognition memory in aging, Neuropsychologia, 35, 129, 10.1016/S0028-3932(96)00073-5 Fabiani, 1998, Individual differences in P3 scalp distribution in older adults, and their relationship to frontal lobe function, Psychophysiology, 35, 698, 10.1111/1469-8986.3560698 Fabiani, 2014, Neurovascular coupling in normal aging: A combined optical, ERP, and fMRI study, NeuroImage, 85, 592, 10.1016/j.neuroimage.2013.04.113 Fabiani, 1996, Naming norms for brief environmental sounds: Effects of age and dementia, Psychophysiology, 33, 462, 10.1111/j.1469-8986.1996.tb01072.x Fabiani, 2014, Taking the pulse of aging: Mapping pulse pressure and elasticity in cerebral arteries with optical methods, Psychophysiology, 51, 1072, 10.1111/psyp.12288 Fabiani, 2015, Chapter 11: Working memory and aging: A review, 131 Falk, 2006, Pathogenesis of atherosclerosis, Journal of the American College of Cardiology, 47, C7, 10.1016/j.jacc.2005.09.068 Fjell, 2015, Development and aging of cortical thickness correspond to genetic organization patterns, Proceedings of the National Academy of Sciences, 112, 15462, 10.1073/pnas.1508831112 Fjell, 2001, P300 and neuropsychological tests as measures of aging: Scalp topography and cognitive changes, Brain Topography, 14, 25, 10.1023/A:1012563605837 Fletcher, 2016, Comparing aging and fitness effects on brain anatomy, Frontiers in Human Neuroscience, 10, 286, 10.3389/fnhum.2016.00286 Friedman, 2017, Unity and diversity of executive functions: Individual differences as a window on cognitive structure, Cortex, 86, 186, 10.1016/j.cortex.2016.04.023 Gallo, 2019, Memory for weather information in younger and older adults: Tests of verbatim and gist memory, Experimental Aging Research, 45, 252, 10.1080/0361073X.2019.1609163 Gianaros, 2018, Host in the machine: A neurobiological perspective on psychological stress and cardiovascular disease, American Psychological Association, 73, 1031, 10.1037/amp0000232 Gordon, 2018, Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 245, 10.1016/j.dadm.2018.02.003 Gordon, 2008, Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education, Psychophysiology, 45, 825, 10.1111/j.1469-8986.2008.00676.x Gordon, 2014, Spread of activation and deactivation in the brain: Does age matter?, Frontiers in Aging Neuroscience, 6, 288, 10.3389/fnagi.2014.00288 Grady, 1995, Age-related reductions in human recognition memory due to impaired encoding, Science, 269, 218, 10.1126/science.7618082 Graf, 1985, Implicit and explicit memory for new associations in normal and amnesic subjects, Journal of Experimental Psychology: Learning, Memory, and Cognition, 11, 501 Gratton, 2017, From brain to blood vessels and back: A non-invasive optical imaging approach, Neurophotonics, 4, 10.1117/1.NPh.4.3.031208 Gratton, 2018, Control networks and hubs, Psychophysiology, 55, 10.1111/psyp.13032 Gratton, 2018, Dynamics of cognitive control: Theoretical bases, paradigms, and a view for the future, Psychophysiology, 55, 10.1111/psyp.13016 Gratton, 2020, Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults, Scientific Reports, 10, 10.1038/s41598-020-76160-9 Groot, 2021, Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β–negative cognitively normal individual, Neurobiology of Aging, 97, 41, 10.1016/j.neurobiolaging.2020.09.017 Guo, 2021, Age, vascular disease, and Alzheimer's disease pathologies in amyloid negative elderly adults, Alzheimer's Research & Therapy, 13, 1, 10.1186/s13195-021-00913-5 Hajjar, 2016, Roles of arterial stiffness and blood pressure in hypertension-associated cognitive decline in healthy adults, Hypertension, 67, 171, 10.1161/HYPERTENSIONAHA.115.06277 Hajjar, 2014, Assessment of cerebrovascular reactivity during resting state breathing and its correlation with cognitive function in hypertension, Cerebrovascular Diseases (Basel, Switzerland), 38, 10, 10.1159/000365349 Hall, 2004, Acute stress affects heart rate variability during sleep, Psychosomatic Medicine, 66, 56, 10.1097/01.PSY.0000106884.58744.09 Hampstead, 2020, Mnemonic strategy training increases neocortical activation in healthy older adults and patients with mild cognitive impairment, International Journal of Psychophysiology, 154, 27, 10.1016/j.ijpsycho.2019.04.011 Hasher, 2008, Inhibitory mechanisms and the control of attention, 227 Hasher, 1988, Working memory, comprehension, and aging: A review and a new view, Psychology of Learning and Motivation, 22, 193, 10.1016/S0079-7421(08)60041-9 Healey, 2008, Cognitive aging and increased distractibility: Costs and potential benefits, Progress in Brain Research, 169, 353, 10.1016/S0079-6123(07)00022-2 Hedden, 2004, Insights into the ageing mind: A view from cognitive neuroscience, Nature Reviews Neuroscience, 5, 87, 10.1038/nrn1323 Hedden, 2013, Meta-analysis of amyloid-cognition relations in cognitively normal older adults, Neurology, 80, 1341, 10.1212/WNL.0b013e31828ab35d Heijnen, 2016, Neuromodulation of aerobic exercise—A review, Frontiers in Psychology, 6, 1890, 10.3389/fpsyg.2015.01890 Henskens, 2008, Increased aortic pulse wave velocity is associated with silent cerebral small-vessel disease in hypertensive patients, Hypertension, 52, 1120, 10.1161/HYPERTENSIONAHA.108.119024 Hindy, 2016, Linking pattern completion in the hippocampus to predictive coding in visual cortex, Nature Neuroscience, 19, 665, 10.1038/nn.4284 Iqbal, 2013, A comprehensive study of the anatomical variations of the circle of Willis in adult human brains, Journal of Clinical and Diagnostic Research, 7, 2423 Isaacs, 1992, Exercise and the brain: Angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning, Journal of Cerebral Blood Flow Metabolism, 12, 110, 10.1038/jcbfm.1992.14 Iwasaki, 2003, Dose-response relationship of the cardiovascular adaptation to endurance training in healthy adults: How much training for what benefit?, Journal of Applied Physiology, 95, 1575, 10.1152/japplphysiol.00482.2003 Jack, 2005, Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI, Neurology, 65, 1227, 10.1212/01.wnl.0000180958.22678.91 Jain, 2014, Inflammation and arterial stiffness in humans, Atherosclerosis, 237, 381, 10.1016/j.atherosclerosis.2014.09.011 James, 1890, The perception of reality, Principles of Psychology, 2, 283 Jefferson, 2016, Effects of resistance training with and without caloric restriction on arterial stiffness in overweight and obese older adults, American Journal of Hypertension, 29, 494, 10.1093/ajh/hpv139 Jennings, 2021, Cerebrovascular function in hypertension: Does high blood pressure make you old?, Psychophysiology, e13654 Jia, 2018, Potential role of antihypertensive medications in preventing excessive arterial stiffening, Current Hypertension Reports, 20, 1, 10.1007/s11906-018-0876-9 Jolly, 2013, Early detection of microstructural white matter changes associated with arterial pulsatility, Frontiers in Human Neuroscience, 7, 782, 10.3389/fnhum.2013.00782 Julius, 1995, The defense reaction: A common denominator of coronary risk and blood pressure in neurogenic hypertension?, Clinical and Experimental Hypertension, 17, 375, 10.3109/10641969509087078 Kalaria, 2012, Cerebrovascular disease and mechanisms of cognitive impairment: Evidence from clinicopathological studies in humans, Stroke, 43, 2526, 10.1161/STROKEAHA.112.655803 Kattoor, 2017, Oxidative stress in atherosclerosis, Current Atherosclerosis Reports, 19, 42, 10.1007/s11883-017-0678-6 Kemper, 1994, Neuroanatomical and neuropathological changes during aging and in dementia, 3 Kirschen, 2018, The hippocampus neuro-glio-vascular network: Metabolic vulnerability and potential neurogenic regeneration in disease, Brain Plasticity, 3, 129, 10.3233/BPL-170055 Kissane, 2019, Exercise-mediated angiogenesis, Current Opinion in Physiology, 10, 193, 10.1016/j.cophys.2019.06.005 Klein, 1999, The reliability and stability of the Turner and Engle working memory task, Behavior Research Methods, Instruments, & Computers, 31, 429, 10.3758/BF03200722 Kong, 2020, Age-related differences in functional brain network segregation are consistent with a cascade of cerebrovascular, structural, and cognitive effects, Network Neuroscience, 4, 89, 10.1162/netn_a_00110 Konkel, 2009, Relational memory and the hippocampus: Representations and methods, Frontiers in Neuroscience, 3, 23, 10.3389/neuro.01.023.2009 Kramer, 2006, Exercise, cognition, and the aging brain, Journal of Applied Physiology, 101, 1237, 10.1152/japplphysiol.00500.2006 Kramer, 1999, Ageing, fitness and neurocognitive function, Nature, 400, 418, 10.1038/22682 Lacolley, 2009, Genetics and pathophysiology of arterial stiffness, Cardiovascular Research, 81, 637, 10.1093/cvr/cvn353 Lähteenvuo, 2012, Effects of aging on angiogenesis, Circulation Research, 110, 1252, 10.1161/CIRCRESAHA.111.246116 Laurent, 2005, Structural and genetic bases of arterial stiffness, Hypertension, 45, 1050, 10.1161/01.HYP.0000164580.39991.3d Leckie, 2014, BDNF mediates improvements in executive function following a 1-year exercise intervention, Frontiers in Human Neuroscience, 8, 985, 10.3389/fnhum.2014.00985 Le-Ha, 2016, Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents, Psychoneuroendocrinology, 66, 118, 10.1016/j.psyneuen.2016.01.002 Leutgeb, 2007, Pattern separation, pattern completion, and new neuronal codes within a continuous CA3 map, Learning & Memory, 14, 745, 10.1101/lm.703907 Li, 2018, Cerebral Small Vessel Disease, Cell Transplantation, 27, 1711, 10.1177/0963689718795148 Libby, 2012, Inflammation in atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology, 32, 2045, 10.1161/ATVBAHA.108.179705 Lin, 2015, Marked gender differences in progression of mild cognitive impairment over 8 years, Alzheimer's & Dementia: Translational Research & Clinical Interventions, 1, 103, 10.1016/j.trci.2015.07.001 Lindenberger, 1997, Intellectual functioning in old and very old age: Cross-sectional results from the Berlin aging study, Psychology and Aging, 12, 410, 10.1037/0882-7974.12.3.410 Loftus, 1997, Memory for a past that never was, Current Directions in Psychological Science, 6, 60, 10.1111/1467-8721.ep11512654 Long, 2019, Alzheimer disease: An update on pathobiology and treatment strategies, Cell, 179, 312, 10.1016/j.cell.2019.09.001 Luchsinger, 2004, Cardiovascular risk factors and Alzheimer's disease, Current Atherosclerosis Reports, 6, 261, 10.1007/s11883-004-0056-z Luciano, 2001, Genetic covariance among measures of information processing speed, working memory, and IQ, Behavior Genetics, 31, 581, 10.1023/A:1013397428612 Madden, 1999, Adult age differences in the functional neuroanatomy of verbal recognition memory, Human Brain Mapping, 7, 115, 10.1002/(SICI)1097-0193(1999)7:2<115::AID-HBM5>3.0.CO;2-N Markus, 2000, Transcranial doppler ultrasound, British Medical Bulletin, 56, 378, 10.1258/0007142001903021 Marr, 1971, Simple memory: A theory for archicortex, Philosophical Transactions of the Royal Society of London B: Biological Sciences, 262, 23, 10.1098/rstb.1971.0078 Marsh, 2005, Learning facts from fiction: Effects of healthy aging and early-stage dementia of the Alzheimer type, Neuropsychology, 19, 115, 10.1037/0894-4105.19.1.115 Mather, 2012, The emotion paradox in the aging brain, Annals of the New York Academy of Sciences, 1251, 33, 10.1111/j.1749-6632.2012.06471.x McEwen, 2000, Allostasis and allostatic load: Implications for neuropsychopharmacology, Neuropsychopharmacology, 22, 108, 10.1016/S0893-133X(99)00129-3 McEwen, 2016, Stress effects on neuronal structure: Hippocampus, amygdala, and prefrontal cortex, Neuropsychopharmacology, 41, 3, 10.1038/npp.2015.171 Medley, 2004, Matrix metalloproteinase-9 genotype influences large artery stiffness through effects on aortic gene and protein expression, Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 1479, 10.1161/01.ATV.0000135656.49158.95 Mendez, 2019, Early-onset Alzheimer disease and its variants, Continuum (Minneapolis, Minn.), 25, 34 Mielke, 2014, Clinical epidemiology of Alzheimer's disease: Assessing sex and gender differences, Clinical Epidemiology, 6, 37, 10.2147/CLEP.S37929 Miller, 2001, An integrative theory of prefrontal cortex function, Annual Reviews of Neuroscience, 24, 167, 10.1146/annurev.neuro.24.1.167 Mills, 2004, The yin and yang of arterial inflammation, Journal of the American College of Cardiology, 44, 50, 10.1016/j.jacc.2004.04.002 Mitchell, 2000, fMRI evidence of age-related hippocampal dysfunction in feature binding in working memory, Cognitive Brain Research, 10, 197, 10.1016/S0926-6410(00)00029-X Miyake, 2012, The nature and organization of individual differences in executive functions, Current Directions in Psychological Science, 21, 8, 10.1177/0963721411429458 Mokhber, 2019, Aging and cognitive function: A mini-review, EC Neurology, 11, 475 Moser, 2008, Place cells, grid cells, and the brain's spatial representation system, Annual Review of Neuroscience, 31, 69, 10.1146/annurev.neuro.31.061307.090723 Mozos, 2017, Inflammatory markers for arterial stiffness in cardiovascular diseases, Frontiers in Immunology, 8, 1058, 10.3389/fimmu.2017.01058 Murman, 2015, The impact of age on cognition, Seminars in Hearing, 36, 111, 10.1055/s-0035-1555115 Nakashiba, 2008, Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning, Science, 319, 1260, 10.1126/science.1151120 Natale, 2021, Glymphatic system as a gateway to connect neurodegeneration from periphery to CNS, Frontiers in Neuroscience, 15, 92, 10.3389/fnins.2021.639140 Nittono, 1999, Event-related potential correlates of individual differences in working memory capacity, Psychophysiology, 36, 745, 10.1111/1469-8986.3660745 Nystoriak, 2018, Cardiovascular effects and benefits of exercise, Frontiers in Cardiovascular Medicine, 5, 135, 10.3389/fcvm.2018.00135 O’Connor, 2021, Stress and health: A review of psychobiological processes, Annual Review of Psychology, 71, 663, 10.1146/annurev-psych-062520-122331 O’Donoghue, 2018, APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review, Cortex, 104, 103, 10.1016/j.cortex.2018.03.025 Park, 2000, The basic mechanisms accounting for age-related decline in cognitive function, 3 Park, 2002, Models of visuospatial and verbal memory across the adult life span, Psychology and Aging, 17, 299, 10.1037/0882-7974.17.2.299 Park, 2001, Cerebral aging: Integration of brain and behavioral models of cognitive function, Dialogues in Clinical Neuroscience, 3, 151, 10.31887/DCNS.2001.3.3/dcpark Pase, 2010, Healthy middle-aged individuals are vulnerable to cognitive deficits as a result of increased arterial stiffness, Journal of Hypertension, 28, 1724, 10.1097/HJH.0b013e32833b1ee7 Peltz, 2011, Age-related changes in electrophysiological and neuropsychological indices of working memory, attention control, and cognitive flexibility, Frontiers in Psychology, 2, 190, 10.3389/fpsyg.2011.00190 Perosa, 2020, Hippocampal vascular reserve associated with cognitive performance and hippocampal volume, Brain, 143, 622, 10.1093/brain/awz383 Persson, 2016, Regional brain shrinkage and change in cognitive performance over two years: The bidirectional influences of the brain and cognitive reserve factors, Neuroimage, 126, 15, 10.1016/j.neuroimage.2015.11.028 Petersen, 1999, Mild cognitive impairment: Clinical characterization and outcome, Archives of Neurology, 56, 303, 10.1001/archneur.56.3.303 Plieger, 2020, Stress & executive functioning: A review considering moderating factors, Neurobiology of Learning and Memory, 173, 10.1016/j.nlm.2020.107254 Plomin, 2001, Genes, brain and cognition, Nature Neuroscience, 4, 1153, 10.1038/nn1201-1153 Polich, 2007, Updating P300: An integrative theory of P3a and P3b, Clinical Neurophysiology, 118, 2128, 10.1016/j.clinph.2007.04.019 Qiu, 2003, Pulse pressure and risk of Alzheimer disease in persons aged 75 years and older: A community-based longitudinal study, Stroke, 34, 594, 10.1161/01.STR.0000060127.96986.F4 Raz, 2000, Aging of the brain and its impact on cognitive performance: Integration of structural and functional findings, 1 Raz, 2018, Pathways to brain aging and their modifiers: Free-radical-induced energetic and neural decline in senescence (FRIENDS) model–A mini-review, Gerontology, 64, 49, 10.1159/000479508 Raz, 2010, Trajectories of brain aging in middle-aged and older adults: Regional and individual differences, NeuroImage, 51, 501, 10.1016/j.neuroimage.2010.03.020 Raz, 2005, Regional brain changes in aging healthy adults: General trends, individual differences and modifiers, Cerebral Cortex, 15, 1676, 10.1093/cercor/bhi044 Reddy, 2020, The sleeping brain: Harnessing the power of the glymphatic system through lifestyle choices, Brain Sciences, 10, 868, 10.3390/brainsci10110868 Rendeiro, 2021, 589 Rhodes, 2019, Age-related differences in recall and recognition: A meta-analysis, Psychonomic Bulletin & Review, 26, 1529, 10.3758/s13423-019-01649-y Rocca, 2014, Sex and gender differences in the causes of dementia: A narrative review, Maturitas, 79, 196, 10.1016/j.maturitas.2014.05.008 Rodrigue, 2012, β-Amyloid burden in healthy aging: Regional distribution and cognitive consequences, Neurology, 78, 387, 10.1212/WNL.0b013e318245d295 Ross, 1995, Cell biology of atherosclerosis, Annual Review of Physiology, 57, 791, 10.1146/annurev.ph.57.030195.004043 Roy, 2018, Emotion regulation moderates the association between chronic stress and cardiovascular disease risk in humans: A cross-sectional study, Stress, 21, 548, 10.1080/10253890.2018.1490724 2021, Psychophysiology, 58 Salthouse, 1992, Influence of processing speed on adult age differences in working memory, Acta Psychologica, 79, 155, 10.1016/0001-6918(92)90030-H Salthouse, 1994, The aging of working memory, Neuropsychology, 8, 535, 10.1037/0894-4105.8.4.535 Sander, 2021, Effects of age differences in memory formation on neural mechanisms of consolidation and retrieval, 116, 135 Santos, 2017, Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 7, 69, 10.1016/j.dadm.2017.01.005 Savitz, 2006, The molecular genetics of cognition: Dopamine, COMT and BDNF, Genes, Brain and Behavior, 5, 311, 10.1111/j.1601-183X.2005.00163.x Schacter, 1996, The role of hippocampus and frontal cortex in age-related memory changes: A PET study, NeuroReport, 7, 1165, 10.1097/00001756-199604260-00014 Schneider-Garces, 2010, Span, CRUNCH and beyond: Working memory capacity and the aging brain, Journal of Cognitive Neuroscience, 22, 655, 10.1162/jocn.2009.21230 Schwarb, 2019, Structural and functional MRI evidence for distinct medial temporal and prefrontal roles in context-dependent relational memory, Journal of Cognitive Neuroscience, 31, 1857, 10.1162/jocn_a_01454 Scuteri, 2005, Arterial stiffness is an independent risk factor for cognitive impairment in the elderly: A pilot study, Journal of Hypertension, 23, 1211, 10.1097/01.hjh.0000170384.38708.b7 Seals, 2008, Habitual exercise and arterial aging, Journal of Applied Physiology, 105, 1323, 10.1152/japplphysiol.90553.2008 Shaw, 2021, Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences, Nature Communications, 12, 1 Shibata, 2018, The effect of lifelong exercise frequency on arterial stiffness, The Journal of Physiology, 596, 2783, 10.1113/JP275301 Shimamura, 1991, What is the role of frontal lobe damage in memory disorders?, 173 Silvestrini, 2011, The role of carotid atherosclerosis in Alzheimer's disease progression, Journal of Alzheimer's Disease, 25, 719, 10.3233/JAD-2011-101968 Singer, 2014, Arterial stiffness, the brain and cognition: A systematic review, Ageing Research Reviews, 15, 16, 10.1016/j.arr.2014.02.002 Sleight, 2021, Cerebrovascular reactivity measurement using magnetic resonance imaging: A systematic review, Frontiers in Physiology, 12, 182, 10.3389/fphys.2021.643468 Squire, 1987 Squire, 1992, Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans, Psychological Review, 99, 582, 10.1037/0033-295X.99.3.582 Squire, 2009, The legacy of patient HM for neuroscience, Neuron, 61, 6, 10.1016/j.neuron.2008.12.023 Stark, 2010, The neural basis of declarative memory Stern, 2012, Cognitive reserve in ageing and Alzheimer's disease, The Lancet Neurology, 11, 1006, 10.1016/S1474-4422(12)70191-6 Stern, 2019, Brain reserve, cognitive reserve, compensation, and maintenance: Operationalization, validity, and mechanisms of cognitive resilience, Neurobiology of Aging, 83, 124, 10.1016/j.neurobiolaging.2019.03.022 Suri, 2020, Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study, PLoS Medicine, 17, 10.1371/journal.pmed.1003467 Tan, 2019, Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging, Neurobiology of Aging, 84, 200, 10.1016/j.neurobiolaging.2019.08.004 Tan, 2017, Mapping cerebral pulse pressure and arterial compliance over the adult lifespan with optical imaging, PLoS One, 12, 10.1371/journal.pone.0171305 Tan, 2016, Optical measures of changes in cerebral vascular tone during voluntary breath holding and a Sternberg memory task, Biological Psychology, 118, 184, 10.1016/j.biopsycho.2016.05.008 Taneja, 2020, Quantitative cerebrovascular reactivity in normal aging: Comparison between phase-contrast and arterial spin labeling MRI, Frontiers in Neurology, 11, 758, 10.3389/fneur.2020.00758 Tarasov, 2009, COL4A1 is associated with arterial stiffness by genome-wide association scan, Circulation: Cardiovascular Genetics, 2, 151 Tarumi, 2015, Central artery stiffness, baroreflex sensitivity, and brain white matter neuronal fiber integrity in older adults, NeuroImage, 110, 162, 10.1016/j.neuroimage.2015.01.041 Thayer, 2021, Stress and aging: A neurovisceral integration perspective, Psychophysiology, 58, 10.1111/psyp.13804 Thompson, 2001, Genetic influences on brain structure, Nature Neuroscience, 4, 1253, 10.1038/nn758 Thompson, 1996, Memory systems in the brain and localization of a memory, Proceedings of the National Academy of Sciences, 93, 13438, 10.1073/pnas.93.24.13438 Tokgöz, 2021, Exercise as potential therapeutic target to modulate Alzheimer's disease pathology in APOE ɛ4 carriers: A systematic review, Cardiology and Therapy, 10, 67, 10.1007/s40119-020-00209-z Tulving, 1972, Episodic and semantic memory, 381 Turner, 1989, Is working memory capacity task dependent?, Journal of Memory and Language, 28, 127, 10.1016/0749-596X(89)90040-5 Van Praag, 2005, Exercise enhances learning and hippocampal neurogenesis in aged mice, Journal of Neuroscience, 25, 8680, 10.1523/JNEUROSCI.1731-05.2005 Vemuri, 2015, Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly, Brain, 138, 761, 10.1093/brain/awu393 Verhaaren, 2013, Alzheimer's disease genes and cognition in the nondemented general population, Biological Psychiatry, 73, 429, 10.1016/j.biopsych.2012.04.009 Verhaeghen, 2011, Aging and executive control: Reports of a demise greatly exaggerated, Current Directions in Psychological Science, 20, 174, 10.1177/0963721411408772 Verhaeghen, 2014 Voss, 2013, Neurobiological markers of exercise-related brain plasticity in older adults, Brain, Behavior, and Immunity, 28, 90, 10.1016/j.bbi.2012.10.021 Voss, 2011, Exercise, brain, and cognition across the life span, Journal of Applied Physiology, 1115, 1505, 10.1152/japplphysiol.00210.2011 Waldstein, 2008, pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore longitudinal study of aging, Hypertension, 51, 99, 10.1161/HYPERTENSIONAHA.107.093674 Walker, 2017, Hippocampal volume and white matter integrity predict cortical indices of reactivation of related items, Neuropsychologia, 95, 182, 10.1016/j.neuropsychologia.2016.12.005 Wang, 2018, Proinflammatory arterial stiffness syndrome: A signature of large arterial aging, Journal of Vascular Research, 55, 210, 10.1159/000490244 Wang, 2022, Changes in hippocampus and amygdala volume with hypoxic stress related to cardiorespiratory fitness under a high-altitude environment, Brain Sciences, 12, 359, 10.3390/brainsci12030359 Wulsin, 2018, Stress, autonomic imbalance, and the prediction of metabolic risk: A model and a proposal for research, Neuroscience and Biobehavioral Reviews, 86, 12, 10.1016/j.neubiorev.2017.12.010 Xie, 2019, Treadmill exercise ameliorates focal cerebral ischemia/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via up regulating caveolin-1/VEGF signaling pathways, Experimental Neurology, 313, 60, 10.1016/j.expneurol.2018.12.005 Zhang, 2021, Gray matter atrophy in amnestic mild cognitive impairment: A voxel-based meta-analysis, Frontiers in Aging Neuroscience, 13, 126 Zimmerman, 2021, Age-related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review, Psychophysiology, 58, 10.1111/psyp.13796 Zimmerman, 2014, Cardiorespiratory fitness mediates the effects of aging on cerebral blood flow, Frontiers in Aging Neuroscience, 6, 59, 10.3389/fnagi.2014.00059 Ziontz, 2019, Tau pathology in cognitively normal older adults, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11, 637, 10.1016/j.dadm.2019.07.007