A gene atlas of the mouse and human protein-encoding transcriptomes

Proceedings of the National Academy of Sciences of the United States of America - Tập 101 Số 16 - Trang 6062-6067 - 2004
Andrew I. Su1, Tim Wiltshire1, Serge Batalov1, Hilmar Lapp1, Keith A. Ching1, David E. Block1, Jie Zhang1, Richard Soden1, Mimi Hayakawa1, Gabriel Kreiman1, M. Cooke1, John R. Walker1, John B. Hogenesch1
1The Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121; and Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, San Diego, CA 92037

Tóm tắt

The tissue-specific pattern of mRNA expression can indicate important clues about gene function. High-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a genome scale. Toward this end, we have designed custom arrays that interrogate the expression of the vast majority of protein-encoding human and mouse genes and have used them to profile a panel of 79 human and 61 mouse tissues. The resulting data set provides the expression patterns for thousands of predicted genes, as well as known and poorly characterized genes, from mice and humans. We have explored this data set for global trends in gene expression, evaluated commonly used lines of evidence in gene prediction methodologies, and investigated patterns indicative of chromosomal organization of transcription. We describe hundreds of regions of correlated transcription and show that some are subject to both tissue and parental allele-specific expression, suggesting a link between spatial expression and imprinting.

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Su, A. I., Welsh, J. B., Sapinoso, L. M., Kern, S. G., Dimitrov, P., Lapp, H., Schultz, P. G., Powell, S. M., Moskaluk, C. A., Frierson, H. F., Jr., et al. (2001) Cancer Res. 61, 7388-7393.11606367

10.1016/S1097-2765(03)00348-4

10.1073/pnas.1934839100

10.1073/pnas.012025199

10.1093/nar/29.1.137

10.1093/nar/30.1.129

10.1038/nature01266

10.1101/gr.229202

10.1093/nar/25.17.3389

10.1101/gr.8.9.967

10.1101/gr.978703

10.1038/nbt1296-1675

10.1093/bioinformatics/18.12.1585

10.1093/nar/30.1.207

10.1073/pnas.1932072100

10.1038/250199a0

10.1016/0092-8674(76)90139-2

10.1016/S0092-8674(01)00467-6

10.1126/science.290.5499.2110

10.1126/science.278.5338.680

10.1182/blood-2002-04-1104

10.1186/1475-4924-1-5

10.1126/science.1056794

10.1038/nature01012

10.1038/79896

10.1038/35013100

10.1038/35013106

10.1101/gad.12.23.3693

10.1093/hmg/8.5.847

10.1016/S0168-9525(03)00082-9

10.1093/oxfordjournals.jbchem.a002971

10.1093/hmg/11.13.1527

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Proceedings of the National Academy of Sciences of the United States of America

Tập 101 Số 16

6062-6067

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