A dynamic model of pneumococcal infection in the United States: Implications for prevention through vaccination

Whitney, 2003, Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine, N Engl J Med, 348, 1737, 10.1056/NEJMoa022823

Kyaw, 2006, Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae, N Engl J Med, 354, 1455, 10.1056/NEJMoa051642

Pelton, 2004, Seven-valent pneumococcal conjugate vaccine immunization in two Boston communities: changes in serotypes and antimicrobial susceptibility among Streptococcus pneumoniae isolates, Pediatr Infect Dis J, 23, 1015, 10.1097/01.inf.0000143645.58215.f0

Singleton, 2007, Invasive pneumococcal disease caused by non-vaccine serotypes among alaska native children with high levels of 7-valent pneumococcal conjugate vaccine coverage, JAMA, 297, 1784, 10.1001/jama.297.16.1784

Huang, 2005, Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004, Pediatrics, 116, e408, 10.1542/peds.2004-2338

Pichichero, 2007, Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children, JAMA, 298, 1772, 10.1001/jama.298.15.1772

Moore, 2008, Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005, J Infect Dis, 197, 1016, 10.1086/528996

Pelton, 2007, Emergence of 19A as virulent and multidrug-resistant Pneumococcus in Massachusetts following universal immunization of infants with pneumococcal conjugate vaccine, Pediatr Infect Dis J, 26, 468, 10.1097/INF.0b013e31803df9ca

Messina, 2007, Impact of the pneumococcal conjugate vaccine on serotype distribution and antimicrobial resistance of invasive Streptococcus pneumoniae isolates in Dallas, TX, children from 1999 through 2005, Pediatr Infect Dis J, 26, 461, 10.1097/INF.0b013e31805cdbeb

Hicks, 2007, Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998–2004, J Infect Dis, 196, 1346, 10.1086/521626

Black, 2007, Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccine, Pediatr Infect Dis J, 26, 771, 10.1097/INF.0b013e318124a494

Lacapa, 2008, Changing epidemiology of invasive pneumococcal disease among White Mountain Apache persons in the era of the pneumococcal conjugate vaccine, Clin Infect Dis, 47, 476, 10.1086/590001

Bingen, 2008, Pneumococcal meningitis in the era of pneumococcal conjugate vaccine implementation, Eur J Clin Microbiol Infect Dis, 27, 191, 10.1007/s10096-007-0417-y

Hanquet, 2008, Dynamic changes of three non-vaccine pneumococcal serotypes in Spain, France, Belgium, England and Wales

Vestrheim, 2008, Effectiveness of a 2+1 dose schedule pneumococcal conjugate vaccination programme on invasive pneumococcal disease among children in Norway, Vaccine, 26, 3277, 10.1016/j.vaccine.2008.03.087

Harboe ZB, Valentiner-Branth P, Benfield TL, Christensen JJ, Andersen PH, Howitz M, et al. Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme. Vaccine January 20.

van der Linden, 2008, Surveillance of IPD in children in Germany 2004–2008; first results of the German national immunization program for PCV7

Hwa Choi, 2008, Streptococcus pneumoniae serotype 19A in children, South Korea, Emerg Infect Dis, 14, 275, 10.3201/eid1402.070807

Dagan, 2009, Introduction and proliferation of multidrug-resistant Streptococcus pneumoniae serotype 19A clones that cause acute otitis media in an unvaccinated population, J Infect Dis

Kaltoft, 2008, An easy method for detection of nasopharyngeal carriage of multiple Streptococcus pneumoniae serotypes, J Microbiol Methods, 75, 540, 10.1016/j.mimet.2008.08.010

O’Brien, 2003, Report from a WHO working group: standard method for detecting upper respiratory carriage of Streptococcus pneumoniae, Pediatr Infect Dis J, 22, 133, 10.1097/01.inf.0000048676.93549.d1

Dagan, 2006, Will reduction of antibiotic use reduce antibiotic resistance?: The pneumococcus paradigm, Pediatr Infect Dis J, 25, 981, 10.1097/01.inf.0000239266.20642.26

Ghaffar, 2000, Effects of amoxicillin/clavulanate or azithromycin on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children with acute otitis media, Clin Infect Dis, 31, 875, 10.1086/318160

Ghaffar, 2002, Effects of large dosages of amoxicillin/clavulanate or azithromycin on nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, non-pneumococcal alpha-hemolytic streptococci, and Staphylococcus aureus in children with acute otitis media, Clin Infect Dis, 34, 1301, 10.1086/340054

Sleeman, 2006, Capsular serotype-specific attack rates and duration of carriage of Streptococcus pneumoniae in a population of children, J Infect Dis, 194, 682, 10.1086/505710

Brueggemann, 2003, Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential, J Infect Dis, 187, 1424, 10.1086/374624

Trzcinski, 2006, Incremental increase in fitness cost with increased beta -lactam resistance in pneumococci evaluated by competition in an infant rat nasal colonization model, J Infect Dis, 193, 1296, 10.1086/501367

Wolter, 2006, Heterogeneous macrolide resistance and gene conversion in the pneumococcus, Antimicrob Agents Chemother, 50, 359, 10.1128/AAC.50.1.359-361.2006

Dagan, 2008, Seasonality of antibiotic-resistant Streptococcus pneumoniae that causes acute otitis media: a clue for an antibiotic-restriction policy?, J Infect Dis, 197, 1094, 10.1086/528995

National Center for Health Statistics. Ambulatory Health Care Data. Available at: http://www.cdc.gov/nchs/ahcd.htm.

Finkelstein, 2003, Antibiotic-resistant Streptococcus pneumoniae in the heptavalent pneumococcal conjugate vaccine era: predictors of carriage in a multicommunity sample, Pediatrics, 112, 862, 10.1542/peds.112.4.862

Huang, 2009, Continued impact of pneumococcal conjugate vaccine on carriage in young children, Pediatrics, 124, e1, 10.1542/peds.2008-3099

Schuchat, 2001, Active bacterial core surveillance of the emerging infections program network, Emerg Infect Dis, 7, 92, 10.3201/eid0701.010114

Dagan, 2002, Reduction of nasopharyngeal carriage of Streptococcus pneumoniae after administration of a 9-valent pneumococcal conjugate vaccine to toddlers attending day care centers, J Infect Dis, 185, 927, 10.1086/339525

Millar, 2008, Indirect effect of 7-valent pneumococcal conjugate vaccine on pneumococcal colonization among unvaccinated household members, Clin Infect Dis, 47, 989, 10.1086/591966

Mbelle, 1999, Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine, J Infect Dis, 180, 1171, 10.1086/315009

Millar, 2006, Effect of community-wide conjugate pneumococcal vaccine use in infancy on nasopharyngeal carriage through 3 years of age: a cross-sectional study in a high-risk population, Clin Infect Dis, 43, 8, 10.1086/504802

O’Brien, 2007, Effect of pneumococcal conjugate vaccine on nasopharyngeal colonization among immunized and unimmunized children in a community-randomized trial, J Infect Dis, 196, 1211, 10.1086/521833

Grivea, 2008, Impact of heptavalent pneumococcal conjugate vaccine on nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae among day-care center attendees in central Greece, Pediatr Infect Dis J, 27, 519, 10.1097/INF.0b013e318168d28a

Cohen, 2006, Impact of pneumococcal conjugate vaccine and of reduction of antibiotic use on nasopharyngeal carriage of non-susceptible pneumococci in children with acute otitis media, Pediatr Infect Dis J, 25, 1001, 10.1097/01.inf.0000243163.85163.a8

Hausdorff WP, Hoet B, Schuerman L. Do pneumococcal conjugate vaccines provide any cross-protection against serotype 19A? BMC Pediatr February 2;10(1): 4.

Whitney, 2006, Effectiveness of 7-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study, Lancet, 368, 1495, 10.1016/S0140-6736(06)69637-2

Eskola, 2001, Efficacy of a pneumococcal conjugate vaccine against acute otitis media, N Engl J Med, 344, 403, 10.1056/NEJM200102083440602

Klugman, 2008, Meta-analysis of the efficacy of conjugate vaccines against invasive pneumococcal disease

Dagan, 2008, Nasopharyngeal carriage of S. pneumoniae vaccine serotypes (VT-Sp) in first 2 years of life following 4 different 7-valent CRMConjugate vaccine (PCV7) schedules

Park, 2008, Differential effects of pneumococcal vaccines against serotypes 6A and 6C, J Infect Dis, 198, 1818, 10.1086/593339

Pai, 2005, Postvaccine genetic structure of Streptococcus pneumoniae serotype 19A from children in the United States, J Infect Dis, 192, 1988, 10.1086/498043

Park, 2008, Impact of conjugate vaccine on transmission of antimicrobial-resistant Streptococcus pneumoniae among Alaskan children, Pediatr Infect Dis J, 27, 335, 10.1097/INF.0b013e318161434d

Kayhty, 2006, Nasopharyngeal colonization: a target for pneumococcal vaccination, Expert Rev Vaccines, 5, 651, 10.1586/14760584.5.5.651

Lipsitch, 1997, Vaccination against colonizing bacteria with multiple serotypes, Proc Natl Acad Sci U S A, 94, 6571, 10.1073/pnas.94.12.6571

Melegaro A. Epidemiology, mathematical modelling and economics of Streptococcus pneumoniae: assessing the potential impact of vaccination. Unpublished doctoral dissertation, University of Warwick, UK. PhD; 2005.

Melegaro, 2007, Pneumococcal carriage in United Kingdom families: estimating serotype-specific transmission parameters from longitudinal data, Am J Epidemiol, 166, 228, 10.1093/aje/kwm076

Karlsson, 2008, An individual-based network model to evaluate interventions for controlling pneumococcal transmission, BMC Infect Dis, 8, 83, 10.1186/1471-2334-8-83

Temime, 2004, Short- and long-term effects of pneumococcal conjugate vaccination of children on penicillin resistance, Antimicrob Agents Chemother, 48, 2206, 10.1128/AAC.48.6.2206-2213.2004

Temime, 2005, Penicillin-resistant pneumococcal meningitis: high antibiotic exposure impedes new vaccine protection, Epidemiol Infect, 133, 493, 10.1017/S0950268804003565

Sutton, 2008, Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in Australia, Math Biosci Eng, 5, 175

Moore, 2004, Impact of a conjugate vaccine on community-wide carriage of non-susceptible Streptococcus pneumoniae in Alaska, J Infect Dis, 190, 2031, 10.1086/425422

Millar, 2009, Nasopharyngeal carriage of Streptococcus pneumoniae in Navajo and White Mountain Apache children before the introduction of pneumococcal conjugate vaccine, Pediatr Infect Dis J, 28, 711, 10.1097/INF.0b013e3181a06303

Anderson, 1991

White, 1998, Cross immunity and vaccination against multiple microparasite strains, IMA J Math Appl Med Biol, 15, 211, 10.1093/imammb/15.3.211

Nuorti, 2008, Uptake of pneumococcal conjugate vaccine among children in the 1998–2002 United States birth cohorts, Am J Prev Med, 34, 46, 10.1016/j.amepre.2007.09.028

United States Census Bureau. United States Census, available at www.census.gov.