A double-blind and cross-over comparison of once daily doxazosin and placebo with steady-state pharmacokinetics in elderly hypertensive patients
Tóm tắt
Từ khóa
Tài liệu tham khảo
Singleton W, Saxton CAPD, Hernandez J, Prichard BNC (1982) Postjunctional selectivity of alpha-blockade with prazosin, trimazosin and UK-33,274 in man. J Cardiovasc Pharmacol 4: S145-S151
Elliott HL, Meredith PA, McLean K, Reid JL (1982) A pharmacodynamic and pharmacokinetic assessment of a new alpha-adrenoceptor antagonist, doxazosin (UK-33,274) in normotensive subjects. Br J Clin Pharmacol 13: 699?703
Elliott HL, Meredith PA, Vincent J, Reid JL (1986) Clinical pharmacological studies with doxazosin. Br J Clin Pharmacol 21: 27S-31S
Vincent J, Meredith PA, Elliott HL, Reid JL (1986) The pharmacokinetics of doxazosin in elderly normotensives. Br J Clin Pharmacol 21: 521?524
Frick MH, Halttunen P, Himanen P, Huttunen M, Pörsti P, Pitkäjärvi L, Pöyhönen M-L, Reinikainen P, Salmela P, Saraste M (1986) A long-term double-blind comparison of doxazosin and atenolol in patients with mild to moderate essential hypertension. Br J Clin Pharmacol 21: 55S-62S
Torvik D, Madsbu H-P (1986) Multicentre 12-week doubleblind comparison of doxazosin, prazosin and placebo in patients with mild to moderate essential hypertension. Br J Clin Pharmacol 21: 69S-75S
Rubin PC, Brunton J, Meredith PA (1980) Determination of the vasodilator UK-33,274 by HPLC using fluorescence detection. J Chromatogr 221: 193?195
Rubin PC, Scott PJW, McLean K, Reid JL (1982) Noradrenaline release and clearance in relation to age and blood pressure in man. Eur J Clin Invest 12: 121?125
MacGilchrist AJ, Hawksley C, Howes LG, Reid JL (1987) The effect of ageing on plasma noradrenaline clearance and spillover rate using tritiated noradrenaline kinetics. Clin Sci 72 [Suppl 16]: 73P
Vestal RE, Wood AJJ, Shand DG (1979) Reduced beta-adrenoceptor sensitivity in the elderly. Clin Pharmacol Ther 26: 181?186
Scott PJW, Reid JL (1982) The effect of age on the responses of human isolated arteries to noradrenaline. Br J Clin Pharmacol 13: 237?239