A dimeric pyrrocidine from Neonectria ramulariae is an inhibitor of prolyl oligopeptidase

Aburai, 2010, Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells, Phytomedicine, 17, 782, 10.1016/j.phymed.2009.12.015 Brayford, 2004, Neonectria and cylindrocarpon: the Nectria mammoidea group and species lacking microconidia, Mycologia, 96, 572, 10.2307/3762176 Gunatilaka, 2006, Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence, J. Nat. Prod., 69, 509, 10.1021/np058128n He, 2002, Pyrrocidines A and B, new antibiotics produced by a filamentous fungus, Tetrahedron Lett., 43, 1633, 10.1016/S0040-4039(02)00099-0 Isaka, 2006, Hirsutellone F, a dimer of antitubercular alkaloids from the seed fungus Trichoderma species BCC 7579, Org. Lett., 8, 2815, 10.1021/ol060926x Isaka, 2005, Hirsutellones A–E, antimycobacterial alkaloids from the insect pathogenic fungus Hirsutella nivea BCC 2594, Tetrahedron, 61, 5577, 10.1016/j.tet.2005.03.099 Kimura, 1990, Staurosporine, a prolyl endopeptidase inhibitor, Agric. Biol. Chem., 54, 3021, 10.1271/bbb1961.54.3021 Kimura, 1997, Propeptin, a new inhibitor of prolyl endopeptidase produced by microbispora 1 – fermentation, isolation and biological properties, J. Antibiot., 50, 373, 10.7164/antibiotics.50.373 Lawandi, 2010, Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors, J. Med. Chem., 53, 3423, 10.1021/jm901104g Strobel, 2004, Natural products from endophytic microorganisms, J. Nat. Prod., 67, 257, 10.1021/np030397v Shiono, 2008, Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria Ramulariae Wollenw KS-246, Bioorg. Med. Chem. Lett., 23, 6050, 10.1016/j.bmcl.2008.10.032 Walter, 1971, Leucylglycinamide released from oxytocin by human uterine enzyme, Science, 173, 827, 10.1126/science.173.3999.827