A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes

Wild, 2004, Global prevalence of diabetes: estimates for the year 2000 and projections for 2030, Diabetes Care, 27, 1047, 10.2337/diacare.27.5.1047

Mahendran, 2013, Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men, Diabetes Care, 36, 3732, 10.2337/dc13-0800

Evans, 2003, Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?, Diabetes, 52, 1, 10.2337/diabetes.52.1.1

Thursby, 2017, Introduction to the human gut microbiota, Biochem J, 474, 1823, 10.1042/BCJ20160510

Flint, 2012, Microbial degradation of complex carbohydrates in the gut, Gut Microbes, 3, 289, 10.4161/gmic.19897

Cani, 2007, Metabolic endotoxemia initiates obesity and insulin resistance, Diabetes, 56, 1761, 10.2337/db06-1491

Allin, 2015, Mechanisms in endocrinology: Gut microbiota in patients with type 2 diabetes mellitus, Eur J Endocrinol, 172, R167, 10.1530/EJE-14-0874

Tang, 2017, Increased trimethylamine n-oxide portends high mortality risk independent of glycemic control in patients with type 2 diabetes mellitus, Clin Chem, 63, 297, 10.1373/clinchem.2016.263640

Pedersen, 2016, Human gut microbes impact host serum metabolome and insulin sensitivity, Nature, 535, 376, 10.1038/nature18646

1998, Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults – The evidence report. National Institutes of Health, Obes Res, 6, 51S

Forslund, 2015, Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota, Nature, 528, 262, 10.1038/nature15766

van der Hulst, 1993, Glutamine and the preservation of gut integrity, Lancet, 341, 1363, 10.1016/0140-6736(93)90939-E

Achamrah, 2017, Glutamine and the regulation of intestinal permeability: from bench to bedside, Curr Opin Clin Nutr Metab Care, 20, 86, 10.1097/MCO.0000000000000339

Inzucchi, 2012, Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD), Diabetes Care, 35, 1364, 10.2337/dc12-0413

Gomes, 2014, Gut microbiota, probiotics and diabetes, Nutr J, 13, 60, 10.1186/1475-2891-13-60

Wexler, 2007, Bacteroides: the good, the bad, and the nitty-gritty, Clin Microbiol Rev, 20, 593, 10.1128/CMR.00008-07

Whiting, 2011, IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030, Diabetes Res Clin Pract, 311, 10.1016/j.diabres.2011.10.029

Vilsboll, 2002, Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients, Diabetologia, 45, 1111, 10.1007/s00125-002-0878-6

Goralska, 2018, Pro-inflammatory gene expression profile in obese adults with high plasma GIP levels, Int J Obes (Lond), 42, 826, 10.1038/ijo.2017.305

Getty-Kaushik, 2006, Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification, Obesity (Silver Spring), 14, 1124, 10.1038/oby.2006.129

Timper, 2013, Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes, Am J Physiol Endocrinol Metab, 304, E1, 10.1152/ajpendo.00100.2012

Boden, 2002, Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction, Eur J Clin Invest, 323, 14, 10.1046/j.1365-2362.32.s3.3.x

Guevara-Cruz, 2010, Increase in HDL-C concentration by a dietary portfolio with soy protein and soluble fiber is associated with the presence of the ABCA1R230C variant in hyperlipidemic Mexican subjects, Mol Genet Metab, 101, 268, 10.1016/j.ymgme.2010.08.007

Wilson, 2007, Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study, Arch Intern Med, 167, 1068, 10.1001/archinte.167.10.1068

Boutagy, 2016, Metabolic endotoxemia with obesity: Is it real and is it relevant?, Biochimie, 124, 11, 10.1016/j.biochi.2015.06.020

Nighot, 2017, Lipopolysaccharide-induced increase in intestinal epithelial tight permeability is mediated by toll-like receptor 4/myeloid differentiation primary response 88 (MyD88) activation of myosin light chain kinase expression, Am J Pathol, 187, 2698, 10.1016/j.ajpath.2017.08.005

Delzenne, 2015, Gut microorganisms as promising targets for the management of type 2 diabetes, Diabetologia, 58, 2206, 10.1007/s00125-015-3712-7

Serralde-Zuniga, 2014, Omental adipose tissue gene expression, gene variants, branched-chain amino acids, and their relationship with metabolic syndrome and insulin resistance in humans, Genes Nutr, 9, 431, 10.1007/s12263-014-0431-5

Li, 2009, Glutamine deprivation alters intestinal tight junctions via a PI3-K/Akt mediated pathway in Caco-2 cells, J Nutr, 139, 710, 10.3945/jn.108.101485

Cabreiro, 2016, Metformin joins forces with microbes, Cell Host Microbe, 19, 1, 10.1016/j.chom.2015.12.012

Qin, 2012, A metagenome-wide association study of gut microbiota in type 2 diabetes, Nature, 490, 55, 10.1038/nature11450

Wang, 2011, Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, Nature, 472, 57, 10.1038/nature09922

Shan, 2017, Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes, Am J Clin Nutr, 106, 888, 10.3945/ajcn.117.157107

Koeth, 2013, Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis, Nat Med, 19, 576, 10.1038/nm.3145

Tuso, 2015, A plant-based diet, atherogenesis, and coronary artery disease prevention, Perm J, 19, 62, 10.7812/TPP/14-036

Jardine, 2016, Nutrition considerations for microbiota health in diabetes., Diabetes Spectr, 29, 238, 10.2337/ds16-0003

Vinke, 2017, The role of supplemental complex dietary carbohydrates and gut microbiota in promoting cardiometabolic and immunological health in obesity: lessons from healthy non-obese individuals, Front Nutr, 4, 34, 10.3389/fnut.2017.00034

Ramnani, 2015, A randomised, double-blind, cross-over study investigating the prebiotic effect of agave fructans in healthy human subjects, J Nutr Sci, 4, e10, 10.1017/jns.2014.68

Lopez-Palacios, 2016, Rheological flow behavior of structural polysaccharides from edible tender cladodes of wild, semidomesticated and cultivated ‘Nopal’ (Opuntia) of Mexican highlands, Plant Foods Hum Nutr, 71, 388, 10.1007/s11130-016-0573-2

Sanchez-Tapia, 2017, Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet, Sci Rep, 7, 4716, 10.1038/s41598-017-05096-4

Lopez-Romero, 2014, The effect of nopal (Opuntia ficus indica) on postprandial blood glucose, incretins, and antioxidant activity in Mexican patients with type 2 diabetes after consumption of two different composition breakfasts, J Acad Nutr Diet, 114, 1811, 10.1016/j.jand.2014.06.352