A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

Cell Metabolism - Tập 34 - Trang 857-873.e9 - 2022
Elena Garreta1, Patricia Prado1, Megan L. Stanifer2,3,4, Vanessa Monteil5, Andrés Marco1, Asier Ullate-Agote6,7,8, Daniel Moya-Rull1, Amaia Vilas-Zornoza6,7,8, Carolina Tarantino1, Juan Pablo Romero6, Gustav Jonsson9, Roger Oria10, Alexandra Leopoldi9, Astrid Hagelkruys9, Maria Gallo1, Federico González1, Pere Domingo-Pedrol11, Aleix Gavaldà12, Carmen Hurtado del Pozo1, Omar Hasan Ali13,14,15
1Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain
2Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany
3Research Group “Cellular Polarity and Viral Infection,” German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA
5Karolinska Institute and Karolinska University Hospital, Unit of Clinical Microbiology, 17182 Stockholm, Sweden
6Área de Hemato-Oncología, Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra (IDISNA), Universidad de Navarra, 31008 Pamplona, Spain
7Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain
8Departamento de Hematología, Clínica Universidad de Navarra, Universidad de Navarra, 31008 Pamplona, Spain
9IMBA Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr-Gasse 3, 1030 Vienna, Austria
10Center for Bioengineering and Tissue Regeneration, UCSF, San Francisco, CA, USA
11Internal Medicine Department, Hospital Universitario de la Santa Creu i Sant Pau, Barcelona, Spain
12Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona and CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Spain
13Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada
14Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
15Institute of Immunobiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

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Cell Metabolism

Tập 34

857-873.e9

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