A confirmatory study of the calibration formula between liver iron concentration (LIC) and R2* values in thalassemia patients
Tóm tắt
To explore the maximum LIC range applicable to LIC-R2* calibration formula of different studies. The liver T2* images of 195 thalassemia patients were measured by CMRtools/Thalassemia Tools (CMRtools), and the calculated T2* values were converted into R2* values. The R2* data were calculated according to the calibration formula of different studies to calculate the corresponding liver iron concentration (LICe), and the relationship between LICe and the liver iron concentration (LICF) provided by FerriScan was compared. Truncation method was adopted to reduce the range, and the maximum LICF ranges corresponding to each formula with no statistical difference and high correlation and consistency were recorded. Clinical grading of LICF and LICe in different range was conducted to explore the relationship between the grading results. There was no significant difference (P > 0.05) between the LICe calculated by different calibration formulas and the corresponding LICF within the applicable maximum LIC value range, and there was a high correlation (rs > 0.75, P < 0.05) and consistency (W > 0.75, P < 0.05) between them. There was no significant difference (P > 0.05) and a high consistency (kappa > 0.75, P < 0.05) between the clinical grading results. Different calibration curves have a specific maximum LIC range when calculating LIC. Different research centers should choose different calibration curves according to the LIC range of their own studies.
Tài liệu tham khảo
Labranche R, Gilbert G, Cerny M, et al. Liver iron quantification with MR imaging: a primer for radiologists. Radiographics. 2018;38(2):392–412. https://doi.org/10.1148/rg.2018170079.
Imajo K, Kessoku T, Honda Y, et al. MRI-based quantitative R2* mapping at 3 tesla reflects hepatic iron overload and pathogenesis in nonalcoholic fatty liver disease patients. J Magn Reson Imaging. 2022;55(1):111–25. https://doi.org/10.1002/jmri.27810.
St Pierre TG, Clark PR, Chua-anusorn W, et al. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood. 2005;105(2):855–61. https://doi.org/10.1182/blood-2004-01-0177.
Craft ML, Edwards M, Jain TP, Choi PY. R2 and R2* MRI assessment of liver iron content in an undifferentiated diagnostic population with hyperferritinaemia, and impact on clinical decision making. Eur J Radiol. 2021;135: 109473. https://doi.org/10.1016/j.ejrad.2020.109473.
Padeniya P, Siriwardana S, Ediriweera D, et al. Comparison of liver MRI R2(FerriScan®) VS liver MRI T2* as a measure of body iron load in a cohort of beta thalassaemia major patients. Orphanet J Rare Dis. 2020;15(1):26. https://doi.org/10.1186/s13023-020-1301-4.
Henninger B, Zoller H, Rauch S, et al. R2* relaxometry for the quantification of hepatic iron overload: biopsy-based calibration and comparison with the literature. Rofo. 2015;187(6):472–9. https://doi.org/10.1055/s-0034-1399318.
Wood JC, Enriquez C, Ghugre N, et al. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood. 2005;106(4):1460–5. https://doi.org/10.1182/blood-2004-10-3982.
Hankins JS, McCarville MB, Loeffler RB, et al. R2* magnetic resonance imaging of the liver in patients with iron overload. Blood. 2009;113(20):4853–5. https://doi.org/10.1182/blood-2008-12-191643.
Garbowski MW, Carpenter JP, Smith G, et al. Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan. J Cardiovasc Magn Reson. 2014;16(1):40. https://doi.org/10.1186/1532-429X-16-40.
Jhaveri KS, Kannengiesser SAR, Ward R, Kuo K, Sussman MS. Prospective evaluation of an R2* method for assessing liver iron concentration (LIC) against FerriScan: derivation of the calibration curve and characterization of the nature and source of uncertainty in the relationship. J Magn Reson Imaging. 2019;49(5):1467–74. https://doi.org/10.1002/jmri.26313.
Hernando D, Cook RJ, Qazi N, Longhurst CA, Diamond CA, Reeder SB. Complex confounder-corrected R2* mapping for liver iron quantification with MRI. Eur Radiol. 2021;31(1):264–75. https://doi.org/10.1007/s00330-020-07123-x.
Henninger B, Plaikner M, Zoller H, et al. Performance of different Dixon-based methods for MR liver iron assessment in comparison to a biopsy-validated R2* relaxometry method. Eur Radiol. 2021;31(4):2252–62. https://doi.org/10.1007/s00330-020-07291-w.
KhadiviHeris H, Nejati B, Rezazadeh K, et al. Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: correlation with serum ferritin, heart function and liver enzymes. J Cardiovasc Thorac Res. 2021;13(1):54–60. https://doi.org/10.34172/jcvtr.2021.18.
Martí-Aguado D, Jiménez-Pastor A, Alberich-Bayarri Á, et al. Automated whole-liver MRI segmentation to assess steatosis and iron quantification in chronic liver disease. Radiology. 2022;302(2):345–54. https://doi.org/10.1148/radiol.2021211027.