A comprehensive approach to therapy of haematological malignancies in older patients

The Lancet Haematology - Tập 8 - Trang e840-e852 - 2021
Raul Cordoba1, Toby A Eyre2, Heidi D Klepin3, Tanya M Wildes4, Valentin Goede5
1Department of Hematology, Fundacion Jimenez Diaz University Hospital, Health Research Institute–Fundacion Jimenez Diaz, Madrid, Spain
2Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford, UK
3Wake Forest School of Medicine, Winston Salem, NC, USA
4Cancer and Aging Research Group, St Louis, MO, USA
5Division of Oncogeriatrics, St Marien Hospital, Cologne, Germany

Tài liệu tham khảo

Sant, 2010, Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project, Blood, 116, 3724, 10.1182/blood-2010-05-282632 Krok-Schoen, 2018, Incidence and survival of hematological cancers among adults ages ≥75 years, Cancer Med, 7, 3425, 10.1002/cam4.1461 Mohile, 2018, Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology, J Clin Oncol, 36, 2326, 10.1200/JCO.2018.78.8687 Abel, 2018, Frailty and the management of hematologic malignancies, Blood, 131, 515, 10.1182/blood-2017-09-746420 Scheepers, 2020, Geriatric assessment in older patients with a hematologic malignancy: a systematic review, Haematologica, 105, 1484, 10.3324/haematol.2019.245803 Soto-Perez-de-Celis, 2021, Implementation of geriatric haematology programmes for the treatment of older people with haematological malignancies in low-resource settings, Lancet Healthy Longev, 10.1016/S2666-7568(21)00182-3 Cannella, 2018, How should we assess patient-reported outcomes in the onco-hematology clinic?, Curr Opin Support Palliat Care, 12, 522, 10.1097/SPC.0000000000000386 Soubeyran, 2019, Approaches for vulnerable and frail older patients with diffuse large B-cell lymphomas, Curr Opin Oncol, 31, 369, 10.1097/CCO.0000000000000559 Tucci, 2015, Comprehensive geriatric assessment is an essential tool to support treatment decisions in elderly patients with diffuse large B-cell lymphoma: a prospective multicenter evaluation in 173 patients by the Lymphoma Italian Foundation (FIL), Leuk Lymphoma, 56, 921, 10.3109/10428194.2014.953142 Merli, 2021, Simplified geriatric assessment in older patients with diffuse large b-cell lymphoma: the prospective elderly project of the Fondazione Italiana Linfomi, J Clin Oncol, 39, 1214, 10.1200/JCO.20.02465 Saffore, 2019, Treatment of older patients with diffuse large B-cell lymphoma and mild cognitive impairment or dementia, J Geriatr Oncol, 10, 510, 10.1016/j.jgo.2018.09.002 Pfreundschuh, 2010, How I treat elderly patients with diffuse large B-cell lymphoma, Blood, 116, 5103, 10.1182/blood-2010-07-259333 Taplitz, 2018, Outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America clinical practice guideline update, J Clin Oncol, 36, 1443, 10.1200/JCO.2017.77.6211 Bartlett, 2020, Approaches to aggressive B-cell lymphomas in less fit patients, Hematology (Am Soc Hematol Educ Program), 2020, 140, 10.1182/hematology.2020000099 Eyre, 2021, Infection-related morbidity and mortality among older patients with DLBCL treated with full- or attenuated-dose R-CHOP, Blood Adv, 5, 2229, 10.1182/bloodadvances.2021004286 Booth, 2020, Fractures are common within 18 months following first-line R-CHOP in older patients with diffuse large B-cell lymphoma, Blood Adv, 4, 4337, 10.1182/bloodadvances.2020002553 Westin, 2013, Zoledronic acid for prevention of bone loss in patients receiving primary therapy for lymphomas: a prospective, randomized controlled phase III trial, Clin Lymphoma Myeloma Leuk, 13, 99, 10.1016/j.clml.2012.11.002 Peyrade, 2011, Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial, Lancet Oncol, 12, 460, 10.1016/S1470-2045(11)70069-9 Peyrade, 2017, Combination of ofatumumab and reduced-dose CHOP for diffuse large B-cell lymphomas in patients aged 80 years or older: an open-label, multicentre, single-arm, phase 2 trial from the LYSA group, Lancet Haematol, 4, e46, 10.1016/S2352-3026(16)30171-5 Pfreundschuh, 2004, Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL, Blood, 104, 634, 10.1182/blood-2003-06-2095 Oberic, 2021, Subcutaneous rituximab-miniCHOP compared with subcutaneous rituximab-miniCHOP plus lenalidomide in diffuse large b-cell lymphoma for patients age 80 years or older, J Clin Oncol, 39, 1203, 10.1200/JCO.20.02666 Fields, 2014, De novo treatment of diffuse large B-cell lymphoma with rituximab, cyclophosphamide, vincristine, gemcitabine, and prednisolone in patients with cardiac comorbidity: a United Kingdom National Cancer Research Institute trial, J Clin Oncol, 32, 282, 10.1200/JCO.2013.49.7586 Storti, 2018, Rituximab plus bendamustine as front-line treatment in frail elderly (>70 years) patients with diffuse large B-cell non-Hodgkin lymphoma: a phase II multicenter study of the Fondazione Italiana Linfomi, Haematologica, 103, 1345, 10.3324/haematol.2017.186569 Luminari, 2018, Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi, Hematol Oncol, 36, 68, 10.1002/hon.2425 Eyre, 2019, Impact of intended and relative dose intensity of R-CHOP in a large, consecutive cohort of elderly diffuse large B-cell lymphoma patients treated with curative intent: no difference in cumulative incidence of relapse comparing patients by age, J Intern Med, 285, 681, 10.1111/joim.12889 Bataillard, 2021, Impact of R-CHOP dose intensity on survival outcomes in diffuse large B-cell lymphoma: a systematic review, Blood Adv, 5, 2426, 10.1182/bloodadvances.2021004665 Moccia, 2021, Long-term outcomes of R-CEOP show curative potential in patients with DLBCL and a contraindication to anthracyclines, Blood Adv, 5, 1483, 10.1182/bloodadvances.2020002982 Eyre, 2019, Stand-alone intrathecal central nervous system (CNS) prophylaxis provide unclear benefit in reducing CNS relapse risk in elderly DLBCL patients treated with R-CHOP and is associated increased infection-related toxicity, Br J Haematol, 187, 185, 10.1111/bjh.16070 Cabannes-Hamy, 2018, Central nervous system relapse in patients over 80 years with diffuse large B-cell lymphoma: an analysis of two LYSA studies, Cancer Med, 7, 539, 10.1002/cam4.1139 Sehn, 2020, Polatuzumab vedotin in relapsed or refractory diffuse large B-cell lymphoma, J Clin Oncol, 38, 155, 10.1200/JCO.19.00172 Salles, 2020, Tafasitamab plus lenalidomide in relapsed or refractory diffuse large B-cell lymphoma (L-MIND): a multicentre, prospective, single-arm, phase 2 study, Lancet Oncol, 21, 978, 10.1016/S1470-2045(20)30225-4 Lin, 2021, Impact and safety of chimeric antigen receptor T-cell therapy in older, vulnerable patients with relapsed/refractory large B-cell lymphoma, Haematologica, 106, 255, 10.3324/haematol.2019.243246 Nastoupil, 2020, Standard-of-care axicabtagene ciloleucel for relapsed or refractory large B-cell lymphoma: results from the US Lymphoma CAR T Consortium, J Clin Oncol, 38, 3119, 10.1200/JCO.19.02104 Eichhorst, 2016, First-line chemoimmunotherapy with bendamustine and rituximab versus fludarabine, cyclophosphamide, and rituximab in patients with advanced chronic lymphocytic leukaemia (CLL10): an international, open-label, randomised, phase 3, non-inferiority trial, Lancet Oncol, 17, 928, 10.1016/S1470-2045(16)30051-1 Goede, 2014, Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions, N Engl J Med, 370, 1101, 10.1056/NEJMoa1313984 Hallek, 2010, Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial, Lancet, 376, 1164, 10.1016/S0140-6736(10)61381-5 Moreno, 2019, Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial, Lancet Oncol, 20, 43, 10.1016/S1470-2045(18)30788-5 Sharman, 2020, Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial, Lancet, 395, 1278, 10.1016/S0140-6736(20)30262-2 Goede, 2016, Evaluation of geriatric assessment in patients with chronic lymphocytic leukemia: results of the CLL9 trial of the German CLL study group, Leuk Lymphoma, 57, 789, 10.3109/10428194.2015.1091933 Molica, 2019, A simple score based on geriatric assessment predicts survival in elderly newly diagnosed chronic lymphocytic leukemia patients, Leuk Lymphoma, 60, 845, 10.1080/10428194.2018.1508674 Bonanad, 2015, Development and psychometric validation of a brief comprehensive health status assessment scale in older patients with hematological malignancies: The GAH Scale, J Geriatr Oncol, 6, 353, 10.1016/j.jgo.2015.03.003 Eichhorst, 2009, First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia, Blood, 114, 3382, 10.1182/blood-2009-02-206185 Hillmen, 2015, Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): a randomised, multicentre, open-label phase 3 trial, Lancet, 385, 1873, 10.1016/S0140-6736(15)60027-7 Michallet, 2018, Rituximab plus bendamustine or chlorambucil for chronic lymphocytic leukemia: primary analysis of the randomized, open-label MABLE study, Haematologica, 103, 698, 10.3324/haematol.2017.170480 Burger, 2015, Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia, N Engl J Med, 373, 2425, 10.1056/NEJMoa1509388 Woyach, 2018, Ibrutinib regimens versus chemoimmunotherapy in older patients with untreated CLL, N Engl J Med, 379, 2517, 10.1056/NEJMoa1812836 Fischer, 2019, Venetoclax and obinutuzumab in patients with CLL and coexisting conditions, N Engl J Med, 380, 2225, 10.1056/NEJMoa1815281 Furman, 2014, Idelalisib and rituximab in relapsed chronic lymphocytic leukemia, N Engl J Med, 370, 997, 10.1056/NEJMoa1315226 Al-Sawaf, 2018, Outcome of patients aged 80 years or older treated for chronic lymphocytic leukaemia, Br J Haematol, 183, 727, 10.1111/bjh.15604 Eyre, 2020, The efficacy and safety of venetoclax therapy in elderly patients with relapsed, refractory chronic lymphocytic leukaemia, Br J Haematol, 188, 918, 10.1111/bjh.16271 Sekeres, 2020, American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults, Blood Adv, 4, 3528, 10.1182/bloodadvances.2020001920 Borlenghi, 2021, Validation of the “fitness criteria” for the treatment of older patients with acute myeloid leukemia: a multicenter study on a series of 699 patients by the Network Rete Ematologica Lombarda (REL), J Geriatr Oncol, 12, 550, 10.1016/j.jgo.2020.10.004 Sorror, 2019, Revised acute myeloid leukemia composite model using the 2017 European LeukemiaNet Risk Classification, JAMA Oncol, 5, 1062, 10.1001/jamaoncol.2019.0902 Klepin, 2013, Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia, Blood, 121, 4287, 10.1182/blood-2012-12-471680 DiNardo, 2018, Durable remissions with ivosidenib in IDH1-mutated relapsed or refractory AML, N Engl J Med, 378, 2386, 10.1056/NEJMoa1716984 Klepin, 2016, Effect of intensive chemotherapy on physical, cognitive, and emotional health of older adults with acute myeloid leukemia, J Am Geriatr Soc, 64, 1988, 10.1111/jgs.14301 Saad, 2020, Geriatric assessment and survival among older adults receiving postremission therapy for acute myeloid leukemia, Blood, 136, 2715, 10.1182/blood.2020005498 Lancet, 2018, CPX-351 (cytarabine and daunorubicin) liposome for injection versus conventional cytarabine plus daunorubicin in older patients with newly diagnosed secondary acute myeloid leukemia, J Clin Oncol, 36, 2684, 10.1200/JCO.2017.77.6112 DiNardo, 2020, Azacitidine and venetoclax in previously untreated acute myeloid leukemia, N Engl J Med, 383, 617, 10.1056/NEJMoa2012971 Wei, 2020, Venetoclax plus LDAC for newly diagnosed AML ineligible for intensive chemotherapy: a phase 3 randomized placebo-controlled trial, Blood, 135, 2137, 10.1182/blood.2020004856 Cortes, 2019, Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome, Leukemia, 33, 379, 10.1038/s41375-018-0312-9 Stein, 2017, Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia, Blood, 130, 722, 10.1182/blood-2017-04-779405 Wei, 2020, Oral azacitidine maintenance therapy for acute myeloid leukemia in first remission, N Engl J Med, 383, 2526, 10.1056/NEJMoa2004444 Stone, 2017, Midostaurin plus chemotherapy for acute myeloid leukemia with a FLT3 mutation, N Engl J Med, 377, 454, 10.1056/NEJMoa1614359 Jones, 2021, Survival trends in elderly myeloma patients, Eur J Haematol, 106, 126, 10.1111/ejh.13530 Facon, 2018, Final analysis of survival outcomes in the phase 3 FIRST trial of up-front treatment for multiple myeloma, Blood, 131, 301, 10.1182/blood-2017-07-795047 Mateos, 2018, Daratumumab plus bortezomib, melphalan, and prednisone for untreated myeloma, N Engl J Med, 378, 518, 10.1056/NEJMoa1714678 Durie, 2017, Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial, Lancet, 389, 519, 10.1016/S0140-6736(16)31594-X Facon, 2019, Daratumumab plus lenalidomide and dexamethasone for untreated myeloma, N Engl J Med, 380, 2104, 10.1056/NEJMoa1817249 Larocca, 2021, Dose/schedule-adjusted Rd-R vs continuous Rd for elderly, intermediate-fit patients with newly diagnosed multiple myeloma, Blood, 137, 3027, 10.1182/blood.2020009507 Giri, 2020, Efficacy and safety of frontline regimens for older transplant-ineligible patients with multiple myeloma: a systematic review and meta-analysis, J Geriatr Oncol, 11, 1285, 10.1016/j.jgo.2020.05.013 Palumbo, 2015, Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report, Blood, 125, 2068, 10.1182/blood-2014-12-615187 Hshieh, 2018, Prevalence of cognitive impairment and association with survival among older patients with hematologic cancers, JAMA Oncol, 4, 686, 10.1001/jamaoncol.2017.5674 Larocca, 2021, Dose/schedule-adjusted Rd-R vs continuous Rd for elderly, intermediate-fit patients with newly diagnosed multiple myeloma, Blood, 137, 3027, 10.1182/blood.2020009507 Cairns, 2019, Frailty-Adjusted Therapy in Transplant Non-Eligible Patients with Newly Diagnosed Multiple Myeloma (FiTNEss): a UK myeloma research alliance study, Myeloma XIV, Blood, 134 Nakaya, 2017, Realistic lenalidomide dose adjustment strategy for transplant-ineligible elderly patients with relapsed/refractory multiple myeloma: Japanese real-world experience, Acta Haematol, 138, 55, 10.1159/000477792 Facon, 2020, Efficacy and safety of carfilzomib-based regimens in frail patients with relapsed and/or refractory multiple myeloma, Blood Adv, 4, 5449, 10.1182/bloodadvances.2020001965 Extermann, 2021, Priorities for the global advancement of care for older adults with cancer: an update of the International Society of Geriatric Oncology Priorities Initiative, Lancet Oncol, 22, e29, 10.1016/S1470-2045(20)30473-3