A comparison of an effect of different anti-inflammatory drugs on human platelets
Tóm tắt
Different doses of aspirin, indomethacin, paracetamol, benorylate, and sodium salicylate were taken by four volunteers. The minimal dose that altered a platelet function test and the persistence of this alteration at different dose levels were studied. Minute doses of indomethacin (0·035 mg/kg) were effective but the effect of even a large single dose did not persist. A tenth of the therapeutic dose of aspirin (1 mg/kg) was effective, and higher doses altered the platelets' function for several days. Benorylate in a high therapeutic dose gave aspirin-like results. Paracetamol and sodium salicylate were relatively inactive. The persistence of the aspirin effect may be related to the acetyl group. These findings are surveyed in relation to a general theory of the action of anti-inflammatory drugs.
Từ khóa
Tài liệu tham khảo
Adams, S. S., and Cobb, R. (1963). In Salicylates: An International Symposium, edited by A. St. J. Dixon, B. K. Martin, M. J. H. Smith, and P. H. N. Wood, p. 127. Churchill, London.
Berry, P. A., and Collier, H. 0. J. (1964). Bronchoconstrictor action and antagonism of a slow-reacting substance from anaphylaxis of guinea-pig isolated lung. Brit. J. Pharmacol., 23, 201-216.
Brown, J. H., and Mackey. H. K. (1968). Further studies on the erythrocyte anti-inflammatory assay. Proc. Soc. exp. Biol. (N. Y.), 128, 504-509.
Inglot, A. D., and Wolna, E. (1968). Reactions of non-steroidal anti-inflammatory drugs with the erythrocyte membrane. Biochem. Pharmacol., 17, 269-279.
O'Brien, J. R. (1964). Variability in the aggregation of human platelets by adrenaline. Nature (Lond.), 202, 1188-1190.
O'Brien, J. R., Finch, W., and Clark, E. (1970). Platelet bound and soluble platelet factor 4: effects of aggregating agents, of aggregation and of aspirin. Proc. Soc. exp. Biol. (N. Y.) (In the press.)
O'Brien, J. R., Heywood, J. B., and Heady, J. A. (1966). The quantitation of platelet aggregation induced by four compounds: a study in relation to myocardial infarction. Thrombos. Diathes. haemorrh. (Stuttg.), 16, 752-767.
Piper, P. J., and Vane, J. R. (1969). Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature (Lond.), 223, 29-35.
Seeman, P. (1966). Erythrocyte membrane stabilization by local anaesthetics and tranquilizers. Biochem. Pharmacol., 15, 1753-1766.
Weiss, H. J., Aledort, L. M., and Kochwa, S. (1968). The effect of salicylates on the hemostatic properties of platelets in man. J. clin. Invest., 47, 2169-2180.
Youssef, A. H., and Barkhan, P. (1969). Inhibition by aspirin of release of antiheparin activity from human platelets. Brit. med. J., 3, 394-396.