A comparison of an effect of different anti-inflammatory drugs on human platelets

Journal of Clinical Pathology - Tập 23 Số 6 - Trang 522-525 - 1970
John O’Brien1, Wendy Finch1, Elizabeth G. Clark1
1Portsmouth and Isle of Wight Area Pathological Service, Milton Road, Portsmouth

Tóm tắt

Different doses of aspirin, indomethacin, paracetamol, benorylate, and sodium salicylate were taken by four volunteers. The minimal dose that altered a platelet function test and the persistence of this alteration at different dose levels were studied. Minute doses of indomethacin (0·035 mg/kg) were effective but the effect of even a large single dose did not persist. A tenth of the therapeutic dose of aspirin (1 mg/kg) was effective, and higher doses altered the platelets' function for several days. Benorylate in a high therapeutic dose gave aspirin-like results. Paracetamol and sodium salicylate were relatively inactive. The persistence of the aspirin effect may be related to the acetyl group. These findings are surveyed in relation to a general theory of the action of anti-inflammatory drugs.

Từ khóa


Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

Journal of Clinical Pathology

Tập 23 Số 6

522-525

Thông tin tác giả