Kết hợp giữa nhiệt phân vi sai và kính hiển vi nóng với phân tích hình ảnh trong việc nghiên cứu đa hình của sulfathiazole

Journal of Thermal Analysis - Tập 99 - Trang 609-619 - 2009
Mohd Rushdi Abu Bakar1, Zoltan Kalman Nagy1, Christopher David Rielly1
1Department of Chemical Engineering, Loughborough University, Loughborough, UK

Tóm tắt

Một sự kết hợp giữa phép đo nhiệt phân vi sai và kính hiển vi nóng cùng với phân tích hình ảnh đã được sử dụng để nghiên cứu đa hình của sulfathiazole. Việc sử dụng các profiles cường độ ánh sáng thu được từ hình ảnh HSM, như một phương pháp thay thế để trình bày kết quả phân tích HSM, đã được chứng minh là hữu ích trong việc mô tả và xác nhận các sự kiện nhiệt. Phương pháp này cung cấp một cái nhìn độc đáo về các biến đổi đa hình và hành vi nhiệt mà hợp chất này thể hiện. Các kết quả của các thí nghiệm cho thấy sulfathiazole có xu hướng kết tinh dưới dạng hỗn hợp các polymorphs, mặc dù các phương pháp được nêu trong tài liệu để sản xuất polymorph tinh khiết đã được tuân thủ.

Từ khóa

#sulfathiazole #đa hình #nhiệt phân vi sai #kính hiển vi nóng #phân tích hình ảnh

Tài liệu tham khảo

Karpinski PH. Polymorphism of active pharmaceutical ingredients. Chem Eng Technol. 2006;29:233–7. Hilfiker R, Blatter F, von Raumer M. Relevance of solid-state properties for pharmaceutical products. In: Hilfiker R, editor. Polymorphism in the pharmaceutical industry. Weinheim: Wiley-VCH Verlag GmbH & Co; 2006. p. 1–18. Kordikowski A, Shekunov T, York P. Polymorph control of sulfathiazole in supercritical CO2. Pharm Res. 2001;18:682–8. Pollanen K, Hakkinen AW, Reinikainen SP, Louhi-Kultanen A, Nystrom L. A study on batch cooling crystallization of sulphathiazole – process monitoring using ATR-FTIR and product characterization by automated image analysis. Chem Eng Res Des. 2006;84:47–59. Abu Bakar MR, Nagy ZK, Saleemi AN, Rielly CD. The impact of direct nucleation control on crystal size distribution in pharmaceutical crystallization processes. Cryst Growth Des. 2009;9:1378–84. Woo XY, Nagy ZK, Tan RBH, Braatz RD. Adaptive concentration control of cooling and antisolvent crystallization with laser backscattering measurement. Cryst Growth Des. 2009;9:182–91. Nagy ZK, Chew JW, Fujiwara M, Braatz RD. Comparative performance of concentration and temperature controlled batch crystallizations. J Process Control. 2008;18:399–407. Craig DQM, Reading M. Thermal analysis of pharmaceuticals. Boca Raton, FL: CRC Press; 2007. Barnes AF, Hardy MJ, Lever TJ. A review of the applications of thermal methods within the pharmaceutical industry. J Therm Anal. 1993;40:499–509. Giron D. Applications of thermal analysis in the pharmaceutical industry. J Pharm Biomed Anal. 1986;4:755–70. Giron D. Thermal analysis and calorimetric methods in the characterization of polymorphs and solvates. Thermochim Acta. 1995;248:1–59. Giron D. Contribution of thermal methods and related techniques to the rational development of pharmaceuticals – part 1. PSTT. 1998;1:191–9. Reading M, Craig DQM. Principles of differential scanning calorimetry. In: Craig DQM, Reading M, editors. Thermal analysis of pharmaceuticals. Boca Raton, FL: CRC Press; 2007. p. 1–20. Clas S-D, Dalton CR, Hancock BC. Differential scanning calorimetry: applications in drug development. PSTT. 1999;2:311–20. Vitez IM, Newman AW, Davidovich M, Kiesnowski C. The evolution of hot-stage microscopy to aid solid-state characterizations of pharmaceutical solids. Thermochim Acta. 1998;324:187–96. Marthi K, Ács M, Pokol G, Tomor K, Eröss-Kiss KJ. DSC studies on the polymorphism and pseudopolymorphism of pharmaceutical substances: a complex system for studying physico-chemical behaviour of binary mixtures. J Therm Anal. 1992;38:1017–25. Vitez IM, Newman AW. Thermal microscopy. In: Craig DQM, Reading M, editors. Thermal analysis of pharmaceuticals. Boca Raton, FL: CRC Press; 2007. p. 221–64. Patience DB, Dell’Orco PC, Rawlings JB. Optimal operation of a seeded pharmaceutical crystallization with growth-dependent dispersion. Org Proc Res Dev. 2004;8:609–15. Calderon De Anda J, Wang XZ, Roberts KJ. Multi-scale segmentation image analysis for the in-process monitoring of particle shape with batch crystallisers. Chem Eng Sci. 2005;60:1053–65. Wang XZ, Roberts KJ, Ma C. Crystal growth measurement using 2D and 3D imaging and the perspectives for shape control. Chem Eng Sci. 2008;63:1173–84. Simon LL, Nagy ZK, Hungerbuehler K. Comparison of external bulk video imaging with focused beam reflectance measurement and ultra-violet visible spectroscopy for metastable zone identification in food and pharmaceutical crystallization processes. Chem Eng Sci. 2009;64:3344–51. Simon LL, Nagy ZK, Hungerbuehler K. Endoscopy-based in situ bulk video imaging of batch crystallization processes. Org Proc Res Dev. 2009. doi:10.1021/op900019b. Giron D. Investigations of polymorphism and pseudo-polymorphism in pharmaceuticals by combined thermoanalytical techniques. J Therm Anal Calorim. 2001;64:37–60. Giron D. Applications of thermal analysis and coupled techniques in pharmaceutical industry. J Therm Anal Calorim. 2002;68:335–57. Pommerenke K. DSC and thermomicroscopy combined. Am Lab. 2000;32:30–2. Richardson MF, Yang Q-C, Novotny-Bregger E, Dunitz JD. Conformational polymorphism of dimethyl 3,6-dichloro-2,5-dihydroxyterephthalate. II. Structural, thermodynamic, kinetic and mechanistic aspects of phase transformations among the three crystal forms. Acta Crystallogr. 1990;B46:653–60. Wiedemann HG, Bayer G. Application of simultaneous thermomicroscopy/DSC to the study of phase diagrams. J Therm Anal. 1985;30:1273–81. Wiedemann HG, Felder-Casagrande S. Thermomicroscopy. In: Brown ME, editor. Handbook of thermal analysis and calorimetry, vol. 1: Principles and practice. Amsterdam: Elsevier Science B.V.; 1998. p. 473–96. da Silva RMF, De Medeiros FPM, Nascimento TG, Macedo RO, Neto PJR. Thermal characterization of indinavir sulfate using TG, DSC and DSC-photovisual. J Therm Anal Calorim. 2009;95:965–8. Apperley DC, Fletton RA, Harris RK, Lancaster RW, Tavener S, Threlfall TL. Sulfathiazole polymorphism studied by magic-angle spinning NMR. J Pharm Sci. 1999;88:1275–80. Chan FC, Anwar J, Cernik R, Barnes P, Wilson RM. Ab initio structure determination of sulfathiazole polymorph V from synchrotron X-ray powder diffraction data. J Appl Crystallogr. 1999;32:436–41. Hughes DS, Hursthouse MB, Threlfall T, Tavener S. A new polymorph of sulfathiazole. Acta Crystallogr C. 1999;55:1831–3. Blagden N, Davey RJ, Lieberman HF, Williams L, Payne R, Roberts R, et al. Crystal chemistry and solvent effects in polymorphic systems: sulfathiazole. J Chem Soc, Faraday Trans. 1998;94:1035–44. Anwar J, Tarling SE, Barnes P. Polymorphism of sulphathiazole. J Pharm Sci. 1989;78:337–42. Lagas M, Lerk CF. The polymorphism of sulphathiazole. Int J Pharm. 1981;8:25–33. Mesley RJ. The polymorphism of sulfathiazole. J Pharm Pharm. 1971;23:687–94. Hughes DS, Hursthouse MB, Lancaster RW, Tavener S, Threlfall T, Turner P. How many polymorphs has sulfathiazole? Proposals for reporting crystallographic data of polymorphs. J Pharm Pharm. 1997;49:20. Anderson JE, Moore S, Tarczynski F, Walker D. Determination of the onset of crystallization of N1-2-(thiazolyl)sulfanilamide (sulfathiazole) by UV-Vis and calorimetry using an automated reaction platform; subsequent characterization of polymorphic forms using dispersive Raman spectroscopy. Spectrochim Acta A. 2001;57:1793–808. Aaltonen J, Rantanen J, Siiria S, Karjalainen M, Jorgensen A, Laitinen N, et al. Polymorph screening using near-infrared spectroscopy. Anal Chem. 2003;75:5267–73. Hakkinen A, Pollanen K, Karjalainen M, Rantanen J, Louhi-Kultanen M, Nystrom L. Batch cooling crystallization and pressure filtration of sulphathiazole: the influence of solvent composition. Biotechnol Appl Biochem. 2005;41:17–28. Khoshkhoo S, Anwar J. Crystallization of polymorphs: the effect of solvent. J Phys D. 1993;26:B90–3. Gelbrich T, Hughes DS, Hursthouse MB, Threlfall TL. Packing similarity in polymorphs of sulfathiazole. Cryst Eng Comm. 2008;10:1328–34. Lever T. Optimizing DSC experiments. In: Craig DQM, Reading M, editors. Thermal analysis of pharmaceuticals. Boca Raton, FL: CRC Press; 2007. p. 24–51. Urakami K, Shono Y, Higashi A, Umemoto K, Godo M. Estimation of transition temperature of pharmaceutical polymorphs by measuring heat of solution and solubility. Bull Chem Soc Jpn. 2002;75:1241–5. Miller RP, Sommer G. A hot stage microscope incorporating a differential thermal analysis unit. J Sci Instrum. 1966;43:293–7. Howard KS, Nagy ZK, Saha B, Robertson AL, Steele G. Combined PAT-solid state analytical approach for the detection and study of sodium benzoate hydrate. Org Proc Res Dev. 2009;13:590–7. Warrington SB. Simultaneous thermal analysis techniques. In: Haines PJ, editor. Principles of thermal analysis and calorimetry. Cambridge: The Royal Society of Chemistry; 2002. p. 166–89.