A checklist for health research priority setting: nine common themes of good practice

Health Research Policy and Systems - Tập 8 Số 1 - 2010
Roderik F. Viergever1, Sylvie Olifson2, Abdul Ghaffar3, Robert Terry4
1Department of Public Health, Innovation and Intellectual Property (PHI), World Health Organization (WHO), Geneva, Switzerland
2Global Forum for Health Research, Geneva, Switzerland
3Alliance for Health Policy and Systems Research, World Health Organization (WHO), Geneva, Switzerland
4WHO strategy on research for health, Department of Research Policy and Cooperation (RPC), World Health Organization (WHO), Geneva, Switzerland

Tóm tắt

Abstract

Health research priority setting processes assist researchers and policymakers in effectively targeting research that has the greatest potential public health benefit. Many different approaches to health research prioritization exist, but there is no agreement on what might constitute best practice. Moreover, because of the many different contexts for which priorities can be set, attempting to produce one best practice is in fact not appropriate, as the optimal approach varies per exercise. Therefore, following a literature review and an analysis of health research priority setting exercises that were organized or coordinated by the World Health Organization since 2005, we propose a checklist for health research priority setting that allows for informed choices on different approaches and outlines nine common themes of good practice. It is intended to provide generic assistance for planning health research prioritization processes. The checklist explains what needs to be clarified in order to establish the context for which priorities are set; it reviews available approaches to health research priority setting; it offers discussions on stakeholder participation and information gathering; it sets out options for use of criteria and different methods for deciding upon priorities; and it emphasizes the importance of well-planned implementation, evaluation and transparency.

Từ khóa


Tài liệu tham khảo

Ranson MK, Bennett SC: Priority setting and health policy and systems research. Health Res Policy Syst. 2009, 7: 27-10.1186/1478-4505-7-27.

Conceição C, Leandro A, McCarthy M: National support to public health research: a survey of European ministries. BMC Public Health. 2009, 9: 203-10.1186/1471-2458-9-203.

Kok M, de Souza DK: Young Voices demand health research goals. Lancet. 2010, 375: 1416-1417. 10.1016/S0140-6736(10)60584-3.

The Bamako call to action on research for health: strengthening research for health, development, and equity. [http://www.who.int/rpc/news/BAMAKOCALLTOACTIONFinalNov24.pdf]

Ahmedov M, Kennedy A, IJsselmuiden C: Governance and policy frameworks for health research in 38 countries. [http://portal.unesco.org/education/en/files/58048/12246671755Ahmedov.pdf/Ahmedov.pdf]

Arudo J, Kamau R, Kamanzi D, Kennedy A: Health research policies and priorities in 19 African low income countries. [http://portal.unesco.org/education/en/files/58049/12246675435Arudo.pdf/Arudo.pdf]

The Expert Working Group on Research and Development Financing: Research and development: coordination and financing: report of the expert working group. 2010, Geneva: World Health Organization, [http://www.who.int/phi/documents/ewg_report/en/index.html]

The Advisory Committee on Health Research: A research policy agenda for science and technology to support global health development. 1998, Geneva: World Health Organization, [http://whqlibdoc.who.int/hq/1998/WHO_RPS_ACHR_98.1.pdf]

Commission on Health Research for Development: Health Research: Essential Link to Equity in Development. 1990, New York: Oxford University Press, [http://www.cohred.org/sites/default/files/EssentialLinktoEquityinDevelopment_0.pdf]

Ad Hoc Committee on Health Research Relating to Future Intervention Options: Investing in Health Research and Development. 1996, Geneva: World Health Organization

Moran M, Guzman J, Ropars AL, McDonald A, Jameson N, Omune B, Ryan S, Wu L: Neglected disease research and development: how much are we really spending?. PLoS Med. 2009, 6: e30-10.1371/journal.pmed.1000030.

Global Forum for Health Research: Monitoring financial flows for health research series. 2001-2009. [http://www.globalforumhealth.org/Media-Publications/Publications/(view)/series/(series)/4]

Murray CJ, Lopez AD: Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet. 1997, 349: 1269-1276. 10.1016/S0140-6736(96)07493-4.

World Health Organization: The global burden of disease: 2004 update. Geneva. 2008, [http://www.who.int/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf]

The Mexico statement on health research: knowledge for better health: strengthening health systems. [http://www.who.int/rpc/summit/agenda/Mexico_Statement-English.pdf]

World Health Assembly document A63/22. WHO's role and responsibilities in health research: WHO strategy on research for health. [http://apps.who.int/gb/ebwha/pdf_files/WHA63/A63_22-en.pdf]

World Health Assembly resolution 63.21. WHO's role and responsibilities in health research. [http://apps.who.int/gb/ebwha/pdf_files/WHA63/A63_R21-en.pdf]

World Health Assembly resolution 61.21. Global strategy and plan of action on public health, innovation and intellectual property. [http://apps.who.int/gb/ebwha/pdf_files/A61/A61_R21-en.pdf]

Viergever RF, Mirza Z, Terry R, Matsoso MP: Prioritisation of health research. Lancet. 2010, 376: 513-10.1016/S0140-6736(10)61247-0.

Priority Setting Methodologies in Health Research: A workshop convened by WHO's Cluster on Information, Evidence and Research (IER), its Department for Research Policy and Cooperation (RPC) and the Special Programme for Research and Training in Tropical Diseases (TDR). [http://apps.who.int/tdr/stewardship/pdf/Priority_setting_Workshop_Summary10_04_08.pdf]

Ghaffar A, Collins T, Matlin SA, Olifson S: The 3D Combined Approach Matrix: An Improved Tool for Setting Priorities in Research for Health. 2009, Geneva: Global Forum for Health Research, [http://www.globalforumhealth.org/content/download/7860/50203/file/CAM_3D_GB.pdf]

Rudan I, El Arifeen S, Black RE: A systematic methodology for setting priorities in child health research investments. A new approach for systematic priority setting. Edited by: Huda TM. 2006, Dhaka: Child Health and Nutrition Research Initiative, 1-11. [http://www.chnri.org/secured/uploads/publications/files/0535210001249198837-604_file_PRIORITY_SETTING_.pdf]

Okello D, Chongtrakul P, COHRED Working Group on Priority Setting: A Manual for Research Priority Setting using the ENHR Strategy. 2000, Geneva: Council on Health Research for Development, [http://www.cohred.org/node/22]

Kaplan WA, Laing R: Priority medicines for europe and the world. 2004, Geneva: World Health Organization, [http://whqlibdoc.who.int/HQ/2004/WHO_EDM_PAR_2004.7.pdf]

de Francisco A: Priority setting in health research. 10/90 Report 2003-2004. Edited by: Davey S. 2004, Geneva: Global Forum for Health Research, 69-104. [http://www.globalforumhealth.org/Media-Publications/Publications/10-90-Report-2003-2004]

Angulo A, Freij L, De Haan S, de los Rios R, Ghaffar A, IJsselmuiden C, Janssens M, Jeenah M, Masood A, Montorzi G, Montoya J: COHRED Working Paper 1. Priority Setting for Health Research: Toward a management process for low and middle income countries. 2006, Geneva: Council on Health Research for Development, [http://www.cohred.org/sites/default/files/WP1_PrioritySetting.pdf]

Fleurence RL, Torgerson DJ: Setting priorities for research. Health Policy. 2004, 69: 1-10. 10.1016/j.healthpol.2003.11.002.

Montorzi G, de Haan S, IJsselmuiden C: Priority Setting for Research for Health: a management process for countries. 2010, Geneva: Council on Health Research for Development, [http://www.cohred.org/sites/default/files/Priority_Setting_COHRED_approach_August_2010.pdf]

Rudan I, Gibson J, Kapiriri L, Lansang MA, Hyder AA, Lawn J, Darmstadt GL, Cousens S, Bhutta ZA, Brown KH, Hess SY, Black M, Gardner JM, Webster J, Carneiro I, Chandramohan D, Kosek M, Lanata CF, Tomlinson M, Chopra M, Ameratunga S, Campbell H, El Arifeen S, Black RE, Child Health and Nutrition Research Initiative (CHNRI): Setting priorities in global child health research investments: assessment of principles and practice. Croat Med J. 2007, 48: 595-604.

Janovsky K, Cassels A: Health policy and systems research: issues, methods, priorities. Health policy and sytems development: an agenda for research. Edited by: Janovsky K. 1996, Geneva: World Health Organization, 11-24. [http://whqlibdoc.who.int/hq/1996/WHO_SHS_NHP_96.1_pp1-124.pdf]

WHO library databases. [http://www.who.int/library/databases/en/]

Viergever RF, Terry R, Matsoso MP: Health research prioritization at WHO: an overview of methodology and high level analysis of WHO led health research priority setting exercises. 2010, Geneva: World Health Organization, [http://www.who.int/rpc/publications/en/]

Ghaffar A: Three pillars of priority setting for health research: process, tools and values. Global Forum Update on Research for Health Volume 3: Combating disease and promoting health. Edited by: Matlin S. 2006, London: Pro-brook Publishing Limited, 117-121. [http://www.globalforumhealth.org/content/download/416/2504/file/s14811e.pdf]

Daniels N: Accountability for reasonableness. BMJ. 2000, 321: 1300-1301. 10.1136/bmj.321.7272.1300.

James C, Carrin G, Savedoff W, Hanvoravongchai P: Clarifying efficiency-equity tradeoffs through explicit criteria, with a focus on developing countries. Health Care Anal. 2005, 13: 33-51. 10.1007/s10728-005-2568-2.

Ghaffar A, de Francisco A, Matlin S: The Combined Approach Matrix: a priority-setting tool for health research. 2004, Geneva: Global Forum for Health Research, [http://www.globalforumhealth.org/Media-Publications/Publications/The-Combined-Approach-Matrix-A-priority-setting-tool-for-health-research]

Ghaffar A: Setting research priorities by applying the combined approach matrix. Indian J Med Res. 2009, 129: 368-375.

Remme JHF, Blas E, Chitsulo L, Desjeux PMP, Engers HD, Kanyok TP, Kengeya Kayondo JF, Kioy DW, Kumaraswami V, Lazdins JK, Nunn PP, Oduola A, Ridley RG, Toure YT, Zicker F, Morel CM: Strategic emphases for tropical diseases research: a TDR perspective. Trends in Parasitology. 2002, 18: 421-426. 10.1016/S1471-4922(02)02387-5.

Henshall C, Oortwijn W, Stevens A, Granados A, Banta D: Priority setting for health technology assessment. Theoretical considerations and practical approaches. Priority setting Subgroup of the EUR-ASSESS Project. Int J Technol Assess Health Care. 1997, 13: 144-185. 10.1017/S0266462300010357.

Lomas J, Fulop N, Gagnon D, Allen P: On being a good listener: setting priorities for applied health services research. Milbank Q. 2003, 81: 363-388. 10.1111/1468-0009.t01-1-00060.

Oxman AD, Schunemann HJ, Fretheim A: Improving the use of research evidence in guideline development: 2. Priority setting. Health Res Policy Syst. 2006, 4: 14-10.1186/1478-4505-4-14.

Cowan K, Oliver S: The James Lind Alliance Guidebook. 2010, Oxford: James Lind Alliance, [http://www.jlaguidebook.org/]

Varkevisser CM, Pathmanathan I, Brownlee A: Module 3: Identifying and prioritising topics for research. Designing and Conducting Health Systems Research Projects: Volume 1: Proposal development and fieldwork. 2003, Amsterdam: KIT Publishers and the International Development Research Centre (IDRC), in association with the Africa Regional Office (AFRO) of the World Health Organization, 27-44. [http://www.idrc.ca/openebooks/069-1/#]

Framework for developing a health systems research agenda. [http://www.who.int/rpc/meetings/Framework_for_developing_a_health_systems_research_agenda.pdf]

Gonzalez-Block M: Health policy and systems research agendas in developing countries. Health Research Policy and Systems. 2004, 2: 6-10.1186/1478-4505-2-6.

Alliance for Health Policy and Systems Research: Strengthening health systems: the role and promise of policy and systems research. 2004, Geneva, [http://www.who.int/alliance-hpsr/resources/Strengthening_complet.pdf]

Philips Z, Claxton KP, Palmer S, Bojke L, Sculpher MJ: Priority setting for research in health care: an application of value of information analysis to glycoprotein IIb/Illa antagonists in non-ST elevation acute coronary syndrome. Int J Technol Assess Health Care. 2006, 22: 379-387. 10.1017/S0266462306051282.

Claxton K, Posnett J: An economic approach to clinical trial design and research priority-setting. Health Econ. 1996, 5: 513-524. 10.1002/(SICI)1099-1050(199611)5:6<513::AID-HEC237>3.0.CO;2-9.

Council on Health Research for Development: Resources for setting priorities. [http://www.cohred.org/Priority-setting-tools]

Organisation for Economic Co-operation and Development: Priority setting: Issues and Recent Trends. Governance of public research: toward better practices. 2003, 61-76. Paris, [http://browse.oecdbookshop.org/oecd/pdfs/browseit/9203051E.PDF]

Callahan D: Shaping biomedical research priorities: the case of the National Institutes of Health. Health Care Anal. 1999, 7: 115-129. 10.1023/A:1009401507982.

McKie J, Shrimpton B, Hurworth R, Bell C, Richardson J: Who should be involved in health care decision making? A qualitative study. Health Care Anal. 2008, 16: 114-126. 10.1007/s10728-007-0051-y.

Sanders D, Labonte R, Baum F, Chopra M: Making research matter: a civil society perspective on health research. Bull World Health Organ. 2004, 82: 757-763.

Smith N, Mitton C, Peacock S, Cornelissen E, MacLeod S: Identifying research priorities for health care priority setting: a collaborative effort between managers and researchers. BMC Health Serv Res. 2009, 9: 165-10.1186/1472-6963-9-165.

Dionne F, Mitton C, Smith N, Donaldson C: Decision maker views on priority setting in the Vancouver Island Health Authority. Cost Eff Resour Alloc. 2008, 6: 13-10.1186/1478-7547-6-13.

Madi BC, Hussein J, Hounton S, D'Ambruoso L, Achadi E, Arhinful DK: Setting priorities for safe motherhood programme evaluation: a participatory process in three developing countries. Health Policy. 2007, 83: 94-104. 10.1016/j.healthpol.2007.01.006.

Andre FE: How the research-based industry approaches vaccine development and establishes priorities. Dev Biol (Basel). 2002, 110: 25-29.

Mitton C, Smith N, Peacock S, Evoy B, Abelson J: Public participation in health care priority setting: A scoping review. Health Policy. 2009, 91: 219-228. 10.1016/j.healthpol.2009.01.005.

Gooberman-Hill R, Horwood J, Calnan M: Citizens' juries in planning research priorities: process, engagement and outcome. Health Expect. 2008, 11: 272-281. 10.1111/j.1369-7625.2008.00502.x.

Staley K: Exploring Impact: Public involvement in NHS, public health and social care research. 2009, Eastleigh: INVOLVE, [http://www.invo.org.uk/pdfs/Involve_Exploring_Impactfinal28.10.09.pdf]

Resnik D: Setting biomedical research priorities: justice, science, and public participation. Kennedy Inst Ethics J. 2001, 11: 181-204. 10.1353/ken.2001.0017.

Oliver SR: How can health service users contribute to the NHS research and development programme?. BMJ. 1995, 310: 1318-1320.

Daniels N, Sabin JE: Accountability for reasonableness. Setting limits fairly: can we learn to share medical resources?. 2002, Oxford: Oxford University Press, 43-66.

Owen P: Clinical practice and medical research: bridging the divide between the two cultures. Br J Gen Pract. 1995, 45: 557-560.

Yang JM, Yu SH, Cho WH: Research fields and priority setting for health sciences in Korea. Yonsei Med J. 1987, 28: 60-70.

Kapiriri L, Tomlinson M, Chopra M, El AS, Black RE, Rudan I: Setting priorities in global child health research investments: addressing values of stakeholders. Croat Med J. 2007, 48: 618-627.

Owens C, Ley A, Aitken P: Do different stakeholder groups share mental health research priorities? A four-arm Delphi study. Health Expect. 2008, 11: 418-431. 10.1111/j.1369-7625.2008.00492.x.

Sharan P, Levav I, Olifson S, de Francisco A, Saxena S: Research capacity for mental health in low- and middle-income countries: Results of a mapping project. 2007, Geneva: Global Forum for Health Research, [http://www.who.int/mental_health/MHRC_FullText.pdf]

Bowling A, Jacobson B, Southgate L: Explorations in consultation of the public and health professionals on priority setting in an inner London health district. Soc Sci Med. 1993, 37: 851-857. 10.1016/0277-9536(93)90138-T.

Griffiths KM, Jorm AF, Christensen H, Medway J, Dear KB: Research priorities in mental health, Part 2: an evaluation of the current research effort against stakeholders' priorities. Aust N Z J Psychiatry. 2002, 36: 327-339. 10.1046/j.1440-1614.2001.01024.x.

Monk JM, Rowley KG, Anderson IP: Setting and meeting priorities in Indigenous health research in Australia and its application in the Cooperative Research Centre for Aboriginal health. Health Res Policy Syst. 2009, 7: 25-10.1186/1478-4505-7-25.

Nuyens Y: Setting priorities for health research: lessons from low- and middle-income countries. Bull World Health Organ. 2007, 85: 319-321. 10.2471/BLT.06.032375.

Htwe M: Research Prioritization. [http://www.searo.who.int/en/Section1243/Section1310/Section1343/Section1344/Section1351/Section1687_7202.htm]

World Health Organization: First formal meeting of the Foodborne Disease Burden Epidemiology Reference Group (FERG): Implementing Strategy, Setting Priorities and Assigning the Tasks. 2008, Geneva, [http://www.who.int/foodsafety/publications/foodborne_disease/FERG_Nov07.pdf]

World Health Organization: WHO Research Agenda for Radiofrequency Fields. 2010, Geneva, [http://www.who.int/peh-emf/research/agenda/en/index.html]

Whitford DL, Jelley D, Gandy S, Southern A, van Zwanenberg T: Making research relevant to the primary health care team. Br J Gen Pract. 2000, 50: 573-576.

Health Research Web. [http://www.healthresearchweb.org/]

The Special Programme for Research and Training in Tropical Diseases: Empowerment (Business Line 2). [http://www.who.int/tdrold/research_lines/bl2.htm]

WHO Public Health Research Agenda for Influenza. [http://www.who.int/csr/disease/influenza/research_agenda/en/index.html]

Lavis J, Permanand G, Oxman A, Lewin S, Fretheim A: SUPPORT Tools for evidence-informed health Policymaking (STP) 13: Preparing and using policy briefs to support evidence-informed policymaking. Health Research Policy and Systems. 2009, 7: S13-10.1186/1478-4505-7-S1-S13.

WHO Evidence-Informed Policy Network (EVIPNet). [http://www.who.int/rpc/evipnet/en/]

Rudan I, Chopra M, Kapiriri L, Gibson J, Ann LM, Carneiro I, Ameratunga S, Tsai AC, Chan KY, Tomlinson M, Hess SY, Campbell H, El Arifeen S, Black RE: Setting priorities in global child health research investments: universal challenges and conceptual framework. Croat Med J. 2008, 49: 307-317. 10.3325/cmj.2008.3.307.

Fraser DW: Overlooked opportunities for investing in health research and development. Bull World Health Organ. 2000, 78: 1054-1061.

Carson N, Ansari Z, Hart W: Priority setting in public health and health services research. Aust Health Rev. 2000, 23: 46-57. 10.1071/AH000046.

Oortwijn WJ, Vondeling H, Bouter L: The use of societal criteria in priority setting for health technology assessment in The Netherlands. Initial experiences and future challenges. Int J Technol Assess Health Care. 1998, 14: 226-236. 10.1017/S0266462300012216.

McDonald D, Bammer G, Deane P: Research Integration Using Dialogue Methods. 2009, Canberra: ANU E Press, [http://epress.anu.edu.au/dialogue_methods_citation.html]

Dalkey N, Helmer O: An Experimental Application of the DELPHI Method to the Use of Experts. Management Science. 1963, 9: 458-467. 10.1287/mnsc.9.3.458.

Van de Ven AH, Delbecq AL: The nominal group as a research instrument for exploratory health studies. Am J Public Health. 1972, 62: 337-342. 10.2105/AJPH.62.3.337.

Angulo-Tuesta A, Becerra-Posada F, Bickis TA, Crespo G, de la Hoz F, Magaña-Izquierdo M, Ortiz Z, Romero-Carniado R, de Francisco A: Experiencias en la Aplicación de la Matriz Combinada en Países de América Latina. 2009, Geneva: Global Forum for Health Research, [http://www.globalforumhealth.org/content/download/7859/50186/file/CAM_LatAm_WEB.pdf]

Sibbald SL, Singer PA, Upshur R, Martin DK: Priority setting: what constitutes success? A conceptual framework for successful priority setting. BMC Health Serv Res. 2009, 9: 43-10.1186/1472-6963-9-43.

Rudan I, Kapiriri L, Tomlinson M, Balliet M, Cohen B, Chopra M: Evidence-based priority setting for health care and research: tools to support policy in maternal, neonatal, and child health in Africa. PLoS Med. 2010, 7: e1000308-10.1371/journal.pmed.1000308.

Ali N, Hill C, Kennedy A, IJsselmuiden C: COHRED Record Paper 5. What factors influence health research agendas in developing countries?. . 2006, Geneva: Council on Health Research for Development, [http://www.cohred.org/sites/default/files/rp5.pdf]

The Paris Declaration and Accra Agenda for Action. [http://www.oecd.org/dataoecd/30/63/43911948.pdf]

Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, Jha P, Mills A, Musgrove P: Disease Control Priorities in Developing Countries: second edition. 2006, Washington: The World Bank and Oxford University Press, [http://www.dcp2.org/pubs/DCP]

Priority setting for health research: lessons from developing countries. The Working Group on Priority Setting. Health Policy Plan. 2000, 15: 130-136. 10.1093/heapol/15.2.130.