A case report of radiotherapy for adenosquamous carcinoma of the pancreas

International Cancer Conference Journal - Tập 4 - Trang 201-205 - 2014
Yaichiro Hashimoto1, Katsuya Maebayashi1, Sachiko Izumi1, Sawa Kono1, Yuka Ishii1, Takashi Hatori2, Toru Furukawa3,4, Norio Mitsuhashi1,5
1Department of Radiation Oncology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan
2Institute of Gastroenterology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan
3Department of Surgical Pathology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan
4Institute of Integrated Medical Sciences, Tokyo Women’s Medical University, Tokyo, Japan
5Cancer Board Division, Radiation Therapy Center, Hitachinaka General Hospital, Hitachinaka, Japan

Tóm tắt

Adenosquamous carcinoma of the pancreas (ASCP) is very rare, comprising only 1–4 % of exocrine malignancies of the pancreas. Several reports have described surgical outcomes for ASCP, but there are few reports of radiotherapy. We treated a case of ASCP with radiotherapy with 50.4 Gy in 28 fractions. The tumor disappeared completely at the end of the radiotherapy but recurred rapidly within the radiation fields, and multiple liver metastases with ascites developed 2 months after treatment, which indicated the possibly high radiosensitivity of the tumor. Initial serum levels of carcinoembryonic antigen, 8.6 ng/mL, and squamous cell-related antigen, 45.8 ng/mL, decreased to within normal limits at the end of radiation therapy, but these 2 tumor markers increased rapidly thereafter.

Tài liệu tham khảo

Madura JA, Jarman BT, Doherty MG et al (1999) Adenosquamous carcinoma of the pancreas. Arch Surg 134:599–603 Kardon DE, Thompson LD, Przygodzki RM et al (2001) Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases. Mod Pathol 14:443–451 Katz MH, Taylor TH, Al-Refaie WB et al (2011) Adenosquamous versus adenocarcinoma of the pancreas: a population-based outcomes analysis. J Gastrointest Surg 15:165–174 Leslie S, Mary G, Christian W (2009) UICC TNM Classification of malignant tumours 7th edn. Wiley-Blackwell, NY Charbit A, Malaise EP, Tubiana M (1971) Relation between the pathological nature and the growth rate of human tumors. Eur J Cancer 7:307–315 Hruban R (2007) Tumors of the pancreas. In: Silverberg S (ed) AFIP atlas of tumor pathology, 6th edn. American Registry of Pathology, Washington, pp 177−181 Aranha GV, Yong S, Olson M (1999) Adenosquamous carcinoma of the pancreas. Int J Pancreatol 26:85–91 Cihak RW, Kawashima T, Steer A (1972) Adenoacanthoma (adenosquamous carcinoma) of the pancreas. Cancer 29:1133–1140 Ishikawa O, Matsui Y, Aoki I et al (1980) Adenosquamous carcinoma of the pancreas: a clinicopathologic study and report of three cases. Cancer 46:1192–1196 Makiyama K, Takuma K, Zea-Iriarte WL et al (1995) Adenosquamous carcinoma of the pancreas. J Gastroenterol 30:798–802 Weitzner S (1978) Adenoacanthoma of the pancreas: report of four cases and literature review. Am Surg 44:206–209 Boyd CA, Benarroch-Gampel J, Sheffield KM et al (2012) 415 patients with adenosquamous carcinoma of the pancreas: a population-based analysis of prognosis and survival. J Surg Res 174:12–19 Trikudanathan G, Dasanu CA (2010) Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity. South Med J 103:903–910 Voong KR, Davison J, Timothy M et al (2010) Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients. Hum Pathol 41:113–122 Shibagaki K, Fujita K, Nakayama S et al (2008) Complete response of a pancreatic adenosquamous carcinoma to chemoradiotherapy. Int J Clin Oncol 13:74–77
Thông tin
Thông tin xuất bản

International Cancer Conference Journal

Tập 4

201-205

Thông tin tác giả