A case of vitiligo after COVID-19 vaccination: a possible role of thymic dysfunction

Journal of Zhejiang University-SCIENCE B - Tập 24 - Trang 1141-1150 - 2023
Denis Kuznetsov1, Oleg Kalyuzhin2, Andrey Mironov1, Valery Neschisliaev3, Anastasiia Kuznetsova3
1G.N. Gabrichevsky Scientific and Research Institute of Epidemiology and Microbiology, Moscow, Russia
2I.M. Sechenov First Moscow State Medical University, Moscow, Russia
3Perm State Pharmaceutical Academy, Perm, Russia

Tóm tắt

最近,人们发现接种2019冠状病毒病(COVID-19)疫苗后出现了大量并发症,影响心脏、肾脏、胰腺、关节和皮肤。本文结合已报道的11例COVID-19疫苗(主要与信使RNA(mRNA)疫苗有关)接种后白癜风病例的数据和我们自己接种的1例非复制载体疫苗后的白癜风病例,分析探讨了其相关的病理机制。根据常见的原理,自身免疫性病变是通过病毒的抗原表位与某些人类蛋白质之间的分子模拟诱发的。我们认为这一过程的基础是胸腺负选择的破坏,导致自身反应性T细胞迁移到外周。在本文中,我们证实了疫苗和/或感染以及黑素细胞氧化应激是自身免疫反应的主要诱因。在这种情况下,白癜风的发病机制可被视为糖尿病或动脉粥样硬化等多种自身免疫性疾病发病机制的模型。此外,我们概述了一种病理机制,其中黑色素细胞氧化应激、自身反应性T细胞和胸腺功能障碍可作为干预策略的潜在目标。

Tài liệu tham khảo

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