A case of breast cancer metastasizing to cervix after resection of pancreatic metastasis
Tóm tắt
A case of breast cancer that metastasized to the cervix 10 years and 8 months after mastectomy is reported. The patient had undergone pancreaticoduodenectomy due to solitary metastasis to the head of the pancreas 4 years previously. The cervical metastasis was associated with abnormal genital bleeding. After pancreaticoduodenectomy the serum levels of CEA, CA15-3 and NCC-ST-439, which are markers of breast cancer, were within normal limits, but the serum level of CA15-3 had increased month by month. The patient had abnormal genital bleeding and presented to the department of gynecology at our hospital. The tumor was in the cervix, bled easily and 2.5 × 2.0 cm in size on ultrasonography. It was thought to be carcinoma of the cervix, but biopsy revealed the tumor to be an adenocarcinoma pathologically and CA15-3 was immunohistochemically demonstrated in the resected specimen, similar to lobular carcinoma of the breast. Abdominal CT scan revealed involvement of the ovaries and uterus, prompting hysterectomy with bilateral oophorectomy. After discharge, she received chemoendocrine therapy. However, she subsequently died due to peritoneal carcinomatosis.
Tài liệu tham khảo
citation_journal_title=Cancer; citation_title=Metastases in carcinoma; Analysis of 1000 autopsied cases; citation_author=HL Abrams, R Spiro, N Goldstein; citation_volume=3; citation_publication_date=1950; citation_pages=74-85; citation_doi=10.1002/1097-0142(1950)3:1<74::AID-CNCR2820030111>3.0.CO;2-7; citation_id=CR1
citation_journal_title=Tan to Sui (J Biliary Tract Pancreas); citation_title=Pathology of metastatic cancer in the pancreas; citation_author=S Kozuka, M Tubota, T Taki; citation_volume=1; citation_publication_date=1980; citation_pages=1531-1535; citation_id=CR2
citation_journal_title=J Surg Oncol; citation_title=Biliary, and pancreatic metastases of breast carcinoma; Is surgical palliation indicated?; citation_author=I Pappo, E Feigin, B Uziely, G Amir; citation_volume=46; citation_publication_date=1991; citation_pages=211-214; citation_doi=10.1002/jso.2930460318; citation_id=CR3
citation_journal_title=Indian J Cancer; citation_title=Isolated pancreatic metastasis from locally controlled breast cancer; A case report; citation_author=SA Mehta, P Jagannath, SC Krishnamurthy, LJ Souza; citation_volume=28; citation_publication_date=1991; citation_pages=48-50; citation_id=CR4
citation_journal_title=Eur J Surg Oncol; citation_title=Pancreatic metastases from breast cancer; An unusual cause of biliary obstruction; citation_author=J Mountney, AC Maury, AM Jackson, RE Coleman, AG Johnson; citation_volume=23; citation_publication_date=1997; citation_pages=574-576; citation_doi=10.1016/S0748-7983(97)93557-5; citation_id=CR5
citation_journal_title=Trans Pathol Soc London; citation_title=Melanotic sarcoma of the eyeball; secondary growth in the organs of the chest and belly, particularly in the liver; citation_author=JW Legg; citation_volume=29; citation_publication_date=1878; citation_pages=225-230; citation_id=CR6
citation_journal_title=Am J Surg; citation_title=Metastatic carcinoma in the uterus; citation_author=H Charache; citation_volume=53; citation_publication_date=1941; citation_pages=152-157; citation_doi=10.1016/S0002-9610(41)90463-4; citation_id=CR7
citation_journal_title=Cancer; citation_title=Metastases to the uterine corpus from extragenital cancers; a clinicopathologic study of 63 cases; citation_author=NB Kumar, WR Hart; citation_volume=50; citation_publication_date=1982; citation_pages=2163-2169; citation_doi=10.1002/1097-0142(19821115)50:10<2163::AID-CNCR2820501032>3.0.CO;2-F; citation_id=CR8
citation_journal_title=Am J Obstet Gynecol; citation_title=Extrapelvic carcinoma metastatic to the uterus; citation_author=GN Stemmermann; citation_volume=82; citation_publication_date=1961; citation_pages=1261-1266; citation_id=CR9
citation_journal_title=Br J Obstet Gynaecol; citation_title=Abnormal uterine bleeding as a presenting sign of metastatic signet ring cell carcinoma originating in the breast; case report; citation_author=B Piura, J Bar-David, J Goldstein; citation_volume=92; citation_publication_date=1985; citation_pages=645-648; citation_id=CR10
citation_journal_title=Eur J Obstet Gynecol; citation_title=Abnormal uterine bleeding as a presenting sign of metastases to the uterine corpus, cervix and vagina in a breast cancer patient on tamoxifen therapy; citation_author=B Piura, I Yanai-Inbar, A Rabinovich, S Zalmanov, J Goldstein; citation_volume=83; citation_publication_date=1999; citation_pages=57-61; citation_doi=10.1016/S0301-2115(98)00268-1; citation_id=CR11
citation_journal_title=Eur J Gynecol Oncol; citation_title=Metastatic breast carcinoma manifesting as postmenopausal Uterine bleeding in a patient on tamoxifen therapy; citation_author=R Maymon, B Czernobilsky, B Lifschitz-Mercer, D Schneider, I Bukovsky, A David; citation_volume=17; citation_publication_date=1996; citation_pages=319-321; citation_id=CR12
citation_journal_title=Abdom Imaging; citation_title=Abdominal metastases of infiltrating lobular breast carcinoma; CT and fluoroscopic imaging findings; citation_author=DD Kidney, AJ Cohen, J Butler; citation_volume=22; citation_publication_date=1997; citation_pages=156-159; citation_doi=10.1007/s002619900161; citation_id=CR13
citation_journal_title=Jpn J Breast Cancer; citation_title=A case of retroperitoneal metastasis of breast cancer; citation_author=F Watanabe, T Nomizu, N Katagata, Y Yamaki, T Saito, A Tsuchiya, R Abe; citation_volume=13; citation_publication_date=1998; citation_pages=808-812; citation_id=CR14
citation_journal_title=Breast Cancer; citation_title=A case of breast cancer metastatic to the head of the pancreas; citation_author=T Nomizu, N Katagata, T Matsuoka, S Suzuki, T Yabuta, F Watanabe, Y Yamaki, T Saito, A Tsuchiya, R Abe; citation_volume=6; citation_publication_date=1999; citation_pages=131-134; citation_id=CR15
citation_journal_title=Int J Cancer; citation_title=Monoclonal antibodies against human milkfat globule membranes detecting differentiation antigens of the mammary gland and its tumor; citation_author=J Hilkens, F Buus, J Hilgers, Ph Hageman, J Calafat, A Sonnenberg, M Valk; citation_volume=34; citation_publication_date=1984; citation_pages=197-206; citation_doi=10.1002/ijc.2910340210; citation_id=CR16
citation_journal_title=Hybridoma; citation_title=Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors; citation_author=D Kufe, G Inghirami, M Abe; citation_volume=3; citation_publication_date=1984; citation_pages=223-231; citation_id=CR17
citation_journal_title=Fukushima Med J; citation_title=Clinical study of CA15-3 in breast cancer as the indicator on the decision of efficacy of treatment in advanced or recurrent breast cancer; citation_author=T Nomizu, M Nihei, S Suzuki, Y Ishii, Y Ando, A Tsuchiya, R Abe; citation_volume=36; citation_publication_date=1986; citation_pages=427-431; citation_id=CR18
citation_journal_title=Jpn J Surg; citation_title=The correlation between the immunohistochemical expression of DF3 antigen and serum CA15-3 in breast cancer patients; citation_author=N Ohuchi, S Sato, M Akimoto, Y Taira, N Matoba, K Takahashi, S Mori; citation_volume=21; citation_publication_date=1991; citation_pages=129-137; citation_doi=10.1007/BF02470899; citation_id=CR19
citation_journal_title=Breast Cancer; citation_title=A case of breast cancer metastatic to the pituitary gland; citation_author=T Nomizu, M Kanno, T Watanabe, F Watanabe, S Suzuki, A Tsuchiya, Y Yamaki, Y Taeda, N Ohuchi, T Saito, R Abe; citation_volume=3; citation_publication_date=1996; citation_pages=71-74; citation_doi=10.1007/BF02966966; citation_id=CR20