A case of Mikulicz’s disease with Th2-biased cytokine profile: possible feature discriminable from Sjögren’s syndrome

Oxford University Press (OUP) - Tập 19 - Trang 691-695 - 2009
Eriko Kudo-Tanaka1, Shinichi Nakatsuka2, Toru Hirano3, Mari Kawai3, Yoshinori Katada4, Masato Matsushita1, Shiro Ohshima1,5, Masaru Ishii1, Kunio Miyatake6, Toshio Tanaka3, Yukihiko Saeki1,5
1Department of Rheumatology, NHO Osaka-Minami Medical Center, Kawachinagano, Japan
2Department of Pathology, NHO Osaka-Minami Medical Center, Kawachinagano, Japan
3Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan
4Department of Allergy, NHO Osaka-Minami Medical Center, Kawachinagano, Japan
5Department of Clinical Research, NHO Osaka-Minami Medical Center, Kawachinagano, Japan
6NHO Osaka-Minami Medical Center, Kawachinagano, Japan

Tóm tắt

This article concerns a male patient with Mikulicz’s disease (MD) accompanied with marked elevation of serum immunoglobulin (Ig)G4 and IgE levels. His peripheral blood mononuclear cells (PBMC) showed markedly enhanced in vitro production of interleukin (IL)-4, IL-5, IL-13, but not interferon gamma (IFN-γ) compared with patients with Sjögren’s syndrome (SS) and healthy donors, suggesting distinct Th2 bias in this MD patient. Besides the prominent infiltration of IgG4-producing plasma cells, the enhanced expression of both CD40 and CD40 ligand (CD40L) were observed in the swollen salivary gland of the MD patient, suggesting enhanced signaling pathways for the induction of IgG4 and IgE switching. Possible differences between MD and SS in light of their underlying pathogenesis are discussed.

Tài liệu tham khảo

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