A Versatile Electronic Tongue Based on Surface Plasmon Resonance Imaging and Cross-Reactive Sensor Arrays—A Mini-Review

Sensors - Tập 17 Số 5 - Trang 1046
Laurie-Amandine Garçon1,2,3,4, María Genua1,2,3, Yanjie Hou1,2,3, Arnaud Buhot1,2,3, R. Calemczuk1,2,3, Thierry Livache1,2,3, Martial Billon1,2,3, Christine Le Narvor5, David Bonnaffé5, Hugues Lortat‐Jacob6,7,8, Yanxia Hou1,2,3
1Centre National de la Recherche Scientifique, SyMMES UMR 5819, F-38000 Grenoble, France
2Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), INAC-SyMMES, F-38000 Grenoble, France
3Institut Nanosciences et Cryogénie, University of Grenoble Alpes, INAC-SyMMES, F-38000 Grenoble, France
4Institut Néel, F-38000 Grenoble, France
5ICMMO/G2M/LCOM, UMR 8182 (CNRS-UPS), LabEx LERMIT, Université Paris-Sud 11, 91405 Orsay CEDEX, France
6Centre National de la Recherche Scientifique, Institut de Biologie Structurale, UMR 5075, 38027 Grenoble, France
7Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Institut de Biologie Structurale, UMR 5075, 38027 Grenoble, France
8Institut de Biologie Structurale, University of Grenoble Alpes, UMR 5075, 38027 Grenoble, France

Tóm tắt

Nowadays, there is a strong demand for the development of new analytical devices with novel performances to improve the quality of our daily lives. In this context, multisensor systems such as electronic tongues (eTs) have emerged as promising alternatives. Recently, we have developed a new versatile eT system by coupling surface plasmon resonance imaging (SPRi) with cross-reactive sensor arrays. In order to largely simplify the preparation of sensing materials with a great diversity, an innovative combinatorial approach was proposed by combining and mixing a small number of easily accessible molecules displaying different physicochemical properties. The obtained eT was able to generate 2D continuous evolution profile (CEP) and 3D continuous evolution landscape (CEL), which is also called 3D image, with valuable kinetic information, for the discrimination and classification of samples. Here, diverse applications of such a versatile eT have been summarized. It is not only effective for pure protein analysis, capable of differentiating protein isoforms such as chemokines CXCL12α and CXCL12γ, but can also be generalized for the analysis of complex mixtures, such as milk samples, with promising potential for monitoring the deterioration of milk.

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