A Sugar Rush for Innate Immunity

Barker, 2013, STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection, MBio, 4, 10.1128/mBio.00018-13 Dey, 2015, A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis, Nat. Med., 21, 401, 10.1038/nm.3813 Gaudet, 2015, INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity, Science, 348, 1251, 10.1126/science.aaa4921 Milivojevic, 2017, ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria, PLoS Pathog., 13, e1006224, 10.1371/journal.ppat.1006224 Mills, 2016, Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages, Cell, 167, 457, 10.1016/j.cell.2016.08.064 Mills, 2018, Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, 113, 10.1038/nature25986 Ratner, 2017, Bacterial secretion systems and regulation of inflammasome activation, J. Leukoc. Biol., 101, 165, 10.1189/jlb.4MR0716-330R Zhou, 2018, Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose, Nature, 561, 122, 10.1038/s41586-018-0433-3 Zimmermann, 2017, ALPK1- and TIFA-dependent innate immune response triggered by the helicobacter pylori type IV secretion system, Cell Rep., 20, 2384, 10.1016/j.celrep.2017.08.039