A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

Cell - Tập 150 - Trang 1235-1248 - 2012
Wolfgang Kastenmüller1, Parizad Torabi-Parizi1,2, Naeha Subramanian1, Tim Lämmermann1, Ronald N. Germain1
1Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
2Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA

Tài liệu tham khảo

Alitalo, 2011, The lymphatic vasculature in disease, Nat. Med., 17, 1371, 10.1038/nm.2545 Asano, 2011, CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens, Immunity, 34, 85, 10.1016/j.immuni.2010.12.011 Bajénoff, 2006, Natural killer cell behavior in lymph nodes revealed by static and real-time imaging, J. Exp. Med., 203, 619, 10.1084/jem.20051474 Bajénoff, 2006, Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes, Immunity, 25, 989, 10.1016/j.immuni.2006.10.011 Barral, 2010, CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes, Nat. Immunol., 11, 303, 10.1038/ni.1853 Belkaid, 2009, Regulatory T cells in the control of host-microorganism interactions, Annu. Rev. Immunol., 27, 551, 10.1146/annurev.immunol.021908.132723 Bendelac, 2007, The biology of NKT cells, Annu. Rev. Immunol., 25, 297, 10.1146/annurev.immunol.25.022106.141711 Benoit, 2008, Macrophage polarization in bacterial infections, J. Immunol., 181, 3733, 10.4049/jimmunol.181.6.3733 Bodey, 1983, Infections caused by Pseudomonas aeruginosa, Rev. Infect. Dis., 5, 279, 10.1093/clinids/5.2.279 Borrow, 1997, Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus, Nat. Med., 3, 205, 10.1038/nm0297-205 Cahalan, 2006, Imaging the choreography of lymphocyte trafficking and the immune response, Curr. Opin. Immunol., 18, 476, 10.1016/j.coi.2006.05.013 Carrasco, 2007, B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node, Immunity, 27, 160, 10.1016/j.immuni.2007.06.007 Castellino, 2006, Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction, Nature, 440, 890, 10.1038/nature04651 Chtanova, 2008, Dynamics of neutrophil migration in lymph nodes during infection, Immunity, 29, 487, 10.1016/j.immuni.2008.07.012 Cinamon, 2008, Follicular shuttling of marginal zone B cells facilitates antigen transport, Nat. Immunol., 9, 54, 10.1038/ni1542 Clark, 2006, The vast majority of CLA+ T cells are resident in normal skin, J. Immunol., 176, 4431, 10.4049/jimmunol.176.7.4431 Davies, 1998, The involvement of cell-to-cell signals in the development of a bacterial biofilm, Science, 280, 295, 10.1126/science.280.5361.295 Dayer, 2003, How T-lymphocytes are activated and become activators by cell-cell interaction, Eur. Respir. J. Suppl., 44, 10s, 10.1183/09031936.03.00000403b DeGrendele, 1997, Requirement for CD44 in activated T cell extravasation into an inflammatory site, Science, 278, 672, 10.1126/science.278.5338.672 Gebhardt, 2009, Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus, Nat. Immunol., 10, 524, 10.1038/ni.1718 Geissmann, 2005, Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids, PLoS Biol., 3, e113, 10.1371/journal.pbio.0030113 Germain, 2008, Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging, Immunol. Rev., 221, 163, 10.1111/j.1600-065X.2008.00591.x Gonzalez, 2010, Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes, Nat. Immunol., 11, 427, 10.1038/ni.1856 Gretz, 1997, Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex, Immunol. Rev., 156, 11, 10.1111/j.1600-065X.1997.tb00955.x Guo, 2009, IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells, Proc. Natl. Acad. Sci. USA, 106, 13463, 10.1073/pnas.0906988106 Hayday, 2009, Gammadelta T cells and the lymphoid stress-surveillance response, Immunity, 31, 184, 10.1016/j.immuni.2009.08.006 Junt, 2007, Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells, Nature, 450, 110, 10.1038/nature06287 Kastenmuller, 2007, Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination, J. Exp. Med., 204, 2187, 10.1084/jem.20070489 Kastenmüller, 2010, The in situ dynamics of dendritic cell interactions, Eur. J. Immunol., 40, 2103, 10.1002/eji.201040482 Kettle, 1997, Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever, J. Gen. Virol., 78, 677, 10.1099/0022-1317-78-3-677 Kupz, 2012, NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8+ T cells, Nat. Immunol., 13, 162, 10.1038/ni.2195 Lämmermann, 2008, The microanatomy of T-cell responses, Immunol. Rev., 221, 26, 10.1111/j.1600-065X.2008.00592.x Lee, 2011, Alternative memory in the CD8 T cell lineage, Trends Immunol., 32, 50, 10.1016/j.it.2010.12.004 Mantovani, 2002, Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes, Trends Immunol., 23, 549, 10.1016/S1471-4906(02)02302-5 Miao, 2008, Pseudomonas aeruginosa activates caspase 1 through Ipaf, Proc. Natl. Acad. Sci. USA, 105, 2562, 10.1073/pnas.0712183105 Miao, 2010, Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria, Nat. Immunol., 11, 1136, 10.1038/ni.1960 Miao, 2010, Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome, Proc. Natl. Acad. Sci. USA, 107, 3076, 10.1073/pnas.0913087107 Miller, 2007, Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo, J. Immunol., 179, 6933, 10.4049/jimmunol.179.10.6933 Moayeri, 2010, Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment, PLoS Pathog., 6, e1001222, 10.1371/journal.ppat.1001222 Norbury, 2002, Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo, Nat. Immunol., 3, 265, 10.1038/ni762 Okada, 2006, B cell migration and interactions in the early phase of antibody responses, Curr. Opin. Immunol., 18, 278, 10.1016/j.coi.2006.02.005 Pereira, 2010, Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses, Int. Immunol., 22, 413, 10.1093/intimm/dxq047 Robinson, 1997, IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB, Immunity, 7, 571, 10.1016/S1074-7613(00)80378-7 Senkevich, 1995, Ectromelia virus RING finger protein is localized in virus factories and is required for virus replication in macrophages, J. Virol., 69, 4103, 10.1128/jvi.69.7.4103-4111.1995 Shi, 2011, Organ-specific features of natural killer cells, Nat. Rev. Immunol., 11, 658, 10.1038/nri3065 Sumen, 2004, Intravital microscopy: visualizing immunity in context, Immunity, 21, 315 Sutterwala, 2007, Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome, J. Exp. Med., 204, 3235, 10.1084/jem.20071239 Swartz, 2001, The physiology of the lymphatic system, Adv. Drug Deliv. Rev., 50, 3, 10.1016/S0169-409X(01)00150-8 Symons, 2002, The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model, J. Gen. Virol., 83, 2833, 10.1099/0022-1317-83-11-2833 Unutmaz, 2000, The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse, J. Immunol., 165, 3284, 10.4049/jimmunol.165.6.3284 van de Veerdonk, 2011, Inflammasome activation and IL-1β and IL-18 processing during infection, Trends Immunol., 32, 110, 10.1016/j.it.2011.01.003 Van Rooijen, 1994, Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications, J. Immunol. Methods, 174, 83, 10.1016/0022-1759(94)90012-4 Wakim, 2010, Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence, Proc. Natl. Acad. Sci. USA, 107, 17872, 10.1073/pnas.1010201107 Weinreich, 2010, T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells, Nat. Immunol., 11, 709, 10.1038/ni.1898 Wu, 2005, Recognition of host immune activation by Pseudomonas aeruginosa, Science, 309, 774, 10.1126/science.1112422 Wyatt, 2009, Elucidating and minimizing the loss by recombinant vaccinia virus of human immunodeficiency virus gene expression resulting from spontaneous mutations and positive selection, J. Virol., 83, 7176, 10.1128/JVI.00687-09 Yang, 2001, IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-gamma production, Nat. Immunol., 2, 157, 10.1038/84264 Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., and Akira, S. (1998). Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143–150. Faust, N., Varas, F., Kelly, L.M., Heck, S., and Graf, T. (2000). Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages. Blood 96, 719–726. Glaccum, M.B., Stocking, K.L., Charrier, K., Smith, J.L., Willis, C.R., Maliszewski, C., Livingston, D.J., Peschon, J.J., and Morrissey, P.J. (1997). Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J. Immunol. 159, 3364–3371. Hu-Li, J., Pannetier, C., Guo, L., Löhning, M., Gu, H., Watson, C., Assenmacher, M., Radbruch, A., and Paul, W.E. (2001). Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene. Immunity 14, 1–11. Koller, B.H., Marrack, P., Kappler, J.W., and Smithies, O. (1990). Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science 248, 1227–1230. Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., and Köhler, G. (1994). Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368, 339–342. Kuida, K., Lippke, J.A., Ku, G., Harding, M.W., Livingston, D.J., Su, M.S., and Flavell, R.A. (1995). Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267, 2000–2003. Lindquist, R.L., Shakhar, G., Dudziak, D., Wardemann, H., Eisenreich, T., Dustin, M.L., and Nussenzweig, M.C. (2004). Visualizing dendritic cell networks in vivo. Nat. Immunol. 5, 1243–1250. Müller, U., Steinhoff, U., Reis, L.F., Hemmi, S., Pavlovic, J., Zinkernagel, R.M., and Aguet, M. (1994). Functional role of type I and type II interferons in antiviral defense. Science 264, 1918–1921. Pérarnau, B., Saron, M.F., Reina San Martin, B., Bervas, N., Ong, H., Soloski, M.J., Smith, A.G., Ure, J.M., Gairin, J.E., and Lemonnier, F.A. (1999). Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses. Eur. J. Immunol. 29, 1243–1252. Sonoda, K.H., Exley, M., Snapper, S., Balk, S.P., and Stein-Streilein, J. (1999). CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J. Exp. Med. 190, 1215–1226. Takeda, K., Tsutsui, H., Yoshimoto, T., Adachi, O., Yoshida, N., Kishimoto, T., Okamura, H., Nakanishi, K., and Akira, S. (1998). Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8, 383–390. Unutmaz, D., Xiang, W., Sunshine, M.J., Campbell, J., Butcher, E., and Littman, D.R. (2000). The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse. J. Immunol. 165, 3284–3292. Wu, C., Wang, X., Gadina, M., O’Shea, J.J., Presky, D.H., and Magram, J. (2000). IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J. Immunol. 165, 6221–6228.