A Single Administration of Synthetic Artificial Stem Cells (SASC) Attenuates Osteoarthritis Progression

Bhattacharjee M, et al. Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment. Proc Natl Acad Sci USA. 2022;119(4):e2120968119. https://doi.org/10.1073/pnas.2120968119.

Shah S, Otsuka T, Bhattacharjee M, Laurencin CT. Minimally Invasive Cellular Therapies for Osteoarthritis Treatment. Regen Eng Transl Med. 2021;7(1):76–90. https://doi.org/10.1007/s40883-020-00184-w.

Daneshmandi L, et al. Emergence of the Stem Cell Secretome in Regenerative Engineering. Trends Biotechnol. 2020;38(12):1373–84. https://doi.org/10.1016/j.tibtech.2020.04.013.

Richardson SM, et al. Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration. Methods. 2016;99:69–80. https://doi.org/10.1016/j.ymeth.2015.09.015.

Mei L, et al. Culture-expanded allogenic adipose tissue-derived stem cells attenuate cartilage degeneration in an experimental rat osteoarthritis model. PLoS ONE. 2017;12(4):e0176107. https://doi.org/10.1371/journal.pone.0176107.

Katagiri W, Sakaguchi K, Kawai T, Wakayama Y, Osugi M, Hibi H. A defined mix of cytokines mimics conditioned medium from cultures of bone marrow-derived mesenchymal stem cells and elicits bone regeneration. Cell Prolif. 2017;50(3):e12333. https://doi.org/10.1111/cpr.12333.

Shah S, Esdaille CJ, Bhattacharjee M, Kan H-M, Laurencin CT. The synthetic artificial stem cell (SASC): Shifting the paradigm of cell therapy in regenerative engineering. Proc Natl Acad Sci USA. 2022;119(2):e2116865118. https://doi.org/10.1073/pnas.2116865118.

Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthr Cartil. 2013;21(1):16–21. https://doi.org/10.1016/j.joca.2012.11.012.

Lawrence T. The Nuclear Factor NF- B Pathway in Inflammation. Cold Spring Harb Perspect Biol. 2009;1(6):a001651–a001651. https://doi.org/10.1101/cshperspect.a001651.

Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling in inflammation. Sig Transduct Target Ther. 2017;2(1):17023. https://doi.org/10.1038/sigtrans.2017.23.

Man GS, Mologhianu G. Osteoarthritis pathogenesis - a complex process that involves the entire joint. J Med Life. 2014;7(1):37–41.

ter Huurne M, et al. Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis. Arthritis Rheum. 2012;64(11):3604–13. https://doi.org/10.1002/art.34626.

Murphy JM, Fink DJ, Hunziker EB, Barry FP. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum. 2003;48(12):3464–74. https://doi.org/10.1002/art.11365.

Ude CC, et al. Cartilage Regeneration by Chondrogenic Induced Adult Stem Cells in Osteoarthritic Sheep Model. PLoS ONE. 2014;9(6):e98770. https://doi.org/10.1371/journal.pone.0098770.

Saito T, Tanaka S. Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB. Arthritis Res Ther. 2017;19(1):94. https://doi.org/10.1186/s13075-017-1296-y.

Mariani E, Pulsatelli L, Facchini A. Signaling Pathways in Cartilage Repair. IJMS. 2014;15(5):8667–98. https://doi.org/10.3390/ijms15058667.

Marcu KB, Otero M, Olivotto E, Maria Borzi R, Goldring MB. NF-κB Signaling: Multiple Angles to Target OA. CDT. 2010;11(5):599–613. https://doi.org/10.2174/138945010791011938.

Burguera EF, Vela-Anero Á, Magalhães J, Meijide-Faílde R, Blanco FJ. Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes. Osteoarthr Cartil. 2014;22(7):1026–35. https://doi.org/10.1016/j.joca.2014.04.031.

Kobayashi M, et al. Role of interleukin-1 and tumor necrosis factor ? in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum. 2005;52(1):128–35. https://doi.org/10.1002/art.20776.

Kojima F, Naraba H, Miyamoto S, Beppu M, Aoki H, Kawai S. Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis. Arthritis Res Ther. 2004;6(4):R355. https://doi.org/10.1186/ar1195.

Olivotto E, Otero M, Marcu KB, Goldring MB. Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation. RMD Open. 2015;1(Suppl 1):e000061. https://doi.org/10.1136/rmdopen-2015-000061.

Montaseri A, et al. IGF-1 and PDGF-bb Suppress IL-1β-Induced Cartilage Degradation through Down-Regulation of NF-κB Signaling: Involvement of Src/PI-3K/AKT Pathway. PLoS ONE. 2011;6(12):e28663. https://doi.org/10.1371/journal.pone.0028663.

Choi Jo. Park, Kang, and Park, “NF-B Signaling Pathways in Osteoarthritic Cartilage Destruction.” Cells. 2019;8(7):734. https://doi.org/10.3390/cells8070734.

Li T, et al. TGF-β type 2 receptor–mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. Sci Transl Med. 2019;11(491):eaan2585. https://doi.org/10.1126/scitranslmed.aan2585.

Li X-G, et al. Fibroblast growth factor 18 alleviates hyperoxia-induced lung injury in mice by adjusting oxidative stress and inflammation. Eur Rev Med Pharmacol Sci. 2021;25(3):1485–94. https://doi.org/10.26355/eurrev_202102_24856.

Bhattacharjee M, et al. Preparation and characterization of amnion hydrogel and its synergistic effect with adipose derived stem cells towards IL1β activated chondrocytes. Sci Rep. 2020;10(1):18751. https://doi.org/10.1038/s41598-020-75921-w.

Sun Z, Nair LS, Laurencin CT. The Paracrine Effect of Adipose-Derived Stem Cells Inhibits IL-1β-induced Inflammation in Chondrogenic Cells through the Wnt/β-Catenin Signaling Pathway. Regen Eng Transl Med. 2018;4(1):35–41. https://doi.org/10.1007/s40883-018-0047-1.

Yang W-T, et al. Stromal-vascular fraction and adipose-derived stem cell therapies improve cartilage regeneration in osteoarthritis-induced rats. Sci Rep. 2022;12(1):2828. https://doi.org/10.1038/s41598-022-06892-3.

Wang RM, et al. Humanized mouse model for assessing the human immune response to xenogeneic and allogeneic decellularized biomaterials. Biomaterials. 2017;129:98–110. https://doi.org/10.1016/j.biomaterials.2017.03.016.

Jenei-Lanzl Z, Meurer A, Zaucke F. Interleukin-1β signaling in osteoarthritis – chondrocytes in focus. Cell Signal. 2019;53:212–23. https://doi.org/10.1016/j.cellsig.2018.10.005.

Ahmad N, Ansari MY, Haqqi TM. Role of iNOS in osteoarthritis: Pathological and therapeutic aspects. J Cell Physiol. 2020;235(10):6366–76. https://doi.org/10.1002/jcp.29607.

Paik J, Duggan ST, Keam SJ. Triamcinolone Acetonide Extended-Release: A Review in Osteoarthritis Pain of the Knee. Drugs. 2019;79(4):455–62. https://doi.org/10.1007/s40265-019-01083-3.

Zhang Z, Huang G. Intra-articular lornoxicam loaded PLGA microspheres: enhanced therapeutic efficiency and decreased systemic toxicity in the treatment of osteoarthritis. Drug Delivery. 2012;19(5):255–63. https://doi.org/10.3109/10717544.2012.700962.

Woods PS et al. Automated Indentation Demonstrates Structural Stiffness of Femoral Articular Cartilage and Temporomandibular Joint Mandibular Condylar Cartilage Is Altered in FgF2KO Mice. CARTILAGE. 2020; 194760352096256. https://doi.org/10.1177/1947603520962565