A Review of Interspecies Toxicity Extrapolation in Birds and Mammals and a Proposal for Long-term Toxicity Data
Tóm tắt
Terrestrial risk assessments for pesticide exposure is generally based on a limited number of toxicity data. The protection target for these assessments requires an extrapolation from species for which toxicity data are available to other species with unknown sensitivity to be able to protect these as well. Our ability to extrapolate toxicity endpoints between species is a major source of uncertainty in risk assessment. Most analyses of interspecies extrapolation in avian risk assessments have dealt with acute toxicity data. It was suggested that, in the absence of a strong rationale to the contrary, we should assume that reproductive data is at least as variable as acute data and that strategies developed for acute data could be applied to long term toxicity data as well. Considering only the two main bird test species for which reproduction data are available (Mallard and Northern Bobwhite), a comparison of the interspecies standard deviation for both acute and reproduction data suggests that the two are equally variable. Analysis of a very limited data set also suggests that this conclusion holds regardless of which endpoint is triggered in the reproduction study. However, the relative sensitivity of the two species established from acute test data appears to be reversed in the case of reproductive data. In addition there seems to be no reason to believe that bodyweight is a factor in helping birds cope with the rigours of chronic dosing, which is in contrast with the acute dosing situation. This suggests that the best extrapolation technique for reproduction test data should be independent of phylogeny and independent of bodyweight scaling. The simplest such method is the one that was proposed by Luttik and Aldenberg (1995, 1997) for both birds and mammals.
Tài liệu tham khảo
Aldenberg, T. (1993). ETX 1.3a, A program to calculate confidence limits for hazardous concentrations based on small samples of toxicity data. RIVM report 719102015. National Institute of Public health and Environment, Bilthoven, The Netherlands
Aldenberg T., Slob W., (1993) Confidence limits for hazardous concentrations based on logistically distributed NOEC toxicity data Ecotoxicol. Environ. Saf. 25:48–63
Aldenberg T., Luttik R., (2002) Extrapolation factors for tiny toxicity data sets from species sensitivity distributions with known standard deviation In: Posthuma L., Suter II G.W., Traas T.P., (eds). Species Sensitivity Distributions in Ecotoxicology. Lewis Publishers, New York, USA, 103–118
Baril, A., Jobin, B., Mineau, P. and Collins, B.T. (1994). A consideration of inter-species variability in the use of the median lethal dose (LD50) in avian risk assessment. Technical Report Series No. 216, Canadian Wildlife Service, Ottawa, Canada
Blus L.J., (2003). Organochlorine pesticides. In Hoffman D.J., Rattner B.A., Burton G.A. Jr., Carlisle J.C., (eds.) Handbook of Ecotoxicology. Lewis Publishers, Boca Raton, 313–39
D’Agostino R.B., Stephens M.A., (1986) Goodness-of-fit Techniques. Statistics: Textbooks and Monographs, (volume 68), Marcel Dekker Inc, New York, United States
Ecofram (Ecological Committee on FIFRA Risk Assessment Methods) (1999). Ecofram terrestrial draft report. http://www.epa.gov/oppefed1/ecorisk/terrreport.pdf
European Union (EU) (2001). Guidance document on Risk Assessment for Birds and Mammals SANCO4145/2000) November 2001, DG Health & Consumer Protection, Brussels, 16 November 2001
European Commission (EC) (2002). Opinion of the Scientific Committee on Plants on the Draft Guidance Document on risk assessment for birds and mammals under Directive 91/414/EEC. SCP/GUIDEB&M/002-Final, Health and Consumer Protection Directorate, Brussels
Fischer, D.L. and Hancock, G.A. (1997). Interspecies extrapolation of acute toxicity in birds: body size scaling vs. phylogeny (abstract) 18th Annual SETAC. San Francisco, CA, USA
Forbes V.E., Calow P., (2002). Species sensitivity distributions revisited: a critical appraisal Hum. Ecol. Risk Assessment 8:473–92
Hart A., Balluff D., Barfknecht R., Chapman P.F., Hawkes T., Joermann G., Leopold A., Luttik R., (2001) Avian Effects Assessment: A Framework for Contaminants Studies. Society of Environmental Toxicology and Chemistry (SETAC), Pensacola, FL, 193
Hart, A. (ed.) (2001). Probabilistic Risk Assessment for Pesticides in Europe: Implementation and Research Needs. Report of the European workshop on Probabilistic Risk Assessment for the Environmental Impacts of Plant Protection Products (EUPRA). Central Science Laboratory, Sand Hutton, UK. 109 pp
Luttik, R. and Aldenberg, T. (1995). Extrapolation factors to be used in case of small samples of toxicity data (with a special focus on LD50 values for birds and mammals). Report No. 679102029. National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
Luttik R., Aldenberg T., (1997) Extrapolation factors for small samples of pesticide toxicity data: special focus on LD50 values for birds and mammals Environ. Toxicol. Chem. 16:1785–88
Mineau P., Boersma D.C., Collins B., (1994). An analysis of avian reproduction studies submitted for pesticide registration Ecotox. Environ. Safe. 29:304–29
Mineau P., Collins B.T., Baril A., (1996) On the use of scaling factors to improve interspecies extrapolation of acute toxicity in birds Regul. Toxicol. Pharm. 24:24–9
Mineau P., Baril A., Collins B.T., Duffe J.A., Joermann G., Luttik R., (2001a) Pesticide acute toxicity reference values for birds Rev. Env. Contam. Toxicol. 170:13–74
Mineau P., Hooper M., Elmegaard N., Grau R., Luttik R., Ringer R., (2001b) Case Study 5: Foliar Insecticide II, Chapter 8. In: Hart A., Balluff D., Barfknecht R., Chapman P., Hawkes A., Joermann G., Leopold A., Luttik R., (eds.) Avian Effects Assessment: A Framework for Contaminant Studies. SETAC Press, Pensacola, Florida. 111–36
Posthuma, L., Suter II, G.W. and Traas, T.P. (eds) (2002). Species Sensitivity Distributions in Ecotoxicology. New York, USA: Lewis Publishers
Sample B.E., Arenal C.A., (1999) Allometric models for interspecies extrapolation of wildlife toxicity data Bull. Environ. Contam. Toxicol. 62:653–63
Schafer, E.W.,Bowles, W.A. and Hurlbut, J. (1983) The acute oral toxicity, repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Arch. Environ. Contam. Toxicol. 12, 355-382
Traas T.P., Luttik R., Jongbloed R.H., (1996) A probabilistic model for deriving soil quality criteria based on secondary poisoning of top predators. I. Model description and uncertainty analysis Ecotox. Environ. Safe. 34:264–78
Van den Brink P.J., Brock T.C.M., Posthuma L., (2002) The value of the species sensitivity distribution concept for predicting field effects: (non-)confirmation of the concept using semifield experiments. In: Posthuma L., Suter II G.W., Traas T.P., (eds), Species Sensitivity Distributions in Ecotoxicology, Lewis Publishers, New York, USA, 103–18