A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate

Structure - Tập 16 - Trang 1588-1597 - 2008
Jorge E. Zuniga1, James J. Schmidt2, Timothy Fenn1, James C. Burnett3, Demet Araç1, Rick Gussio4, Robert G. Stafford2, Shirin S. Badie2, Sina Bavari2, Axel T. Brunger1
1Howard Hughes Medical Institute and Departments of Molecular and Cellular Physiology, Neurology and Neurological Science, Structural Biology, and Photon Science, Stanford University, Stanford, CA 94305, USA
2United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
3Target Structure-Based Drug Discovery Group, SAIC-Frederick, Inc., National Cancer Institute, Frederick, MD 21702, USA
4Developmental Therapeutics Program, National Cancer Institute, Frederick, MD 21702, USA

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