A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis
Tóm tắt
Từ khóa
Tài liệu tham khảo
Machado, 2006, Hepatic histology in obese patients undergoing bariatric surgery, J Hepatol, 45, 600, 10.1016/j.jhep.2006.06.013
Wanless, 1990, Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors, Hepatology, 12, 1106, 10.1002/hep.1840120505
Harrison, 2004, Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, Clin Liver Dis, 8, 861, 10.1016/j.cld.2004.06.008
Defronso, 1991, Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease, Diabetes Care, 14, 173, 10.2337/diacare.14.3.173
Day, 1998, Steatohepatitis: a tale of two “hits”? [editorial], Gastroenterology, 114, 842, 10.1016/S0016-5085(98)70599-2
Kaplan, 1998, Leptin, obesity, and liver disease, Gastroenterology, 115, 997, 10.1016/S0016-5085(98)70272-0
Harrison, 2002, Nonalcoholic Steatohepatitis: what we know in the new millennium, Am J Gastroenterol, 97, 2714
Adams, 2005, The natural history of nonalcoholic fatty liver, Gastroenteroloy, 129, 113, 10.1053/j.gastro.2005.04.014
Hussein, 2007, Orlistat reverse fatty infiltration and improves hepatic fibrosis in obese patients with nonalcoholic steatohepatitis (NASH), Dig Dis Sci, 52, 2512, 10.1007/s10620-006-9631-1
Harrison, 2003, Vitamin E and C treatment improves fibrosis in patients with nonalcoholic steatohepatitis, Am J Gastroenterol, 98, 2485, 10.1111/j.1572-0241.2003.08699.x
Sanyal, 2004, A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis, Clin Gastroenterol Hepatol, 2, 1107, 10.1016/S1542-3565(04)00457-4
Lindor, 2004, Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial, Hepatology, 39, 770, 10.1002/hep.20092
Merat, 2003, Probucol in the treatment of nonalcoholic steatohepatitis: an open-labeled study, J Clin Gastroenterol, 36, 266, 10.1097/00004836-200303000-00015
Deushi, 2007, Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome, FEBS Lett, 581, 5664, 10.1016/j.febslet.2007.11.023
Yokohama, 2004, Therapeutic efficacy of an antiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis, Hepatology, 40, 1222, 10.1002/hep.20420
Bugianesi, 2005, A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease, Am J Gastroenterol, 100, 1082, 10.1111/j.1572-0241.2005.41583.x
Belfort, 2006, A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis, N Engl J Med, 355, 2297, 10.1056/NEJMoa060326
Ding, 2006, Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice, Hepatology, 43, 173, 10.1002/hep.21006
Georgescu, 2007, Therapeutic options in non-alcoholic steatohepatitis (NASH). Are all agents alike? Results of a Preliminary Study, J Gastrointestinal Liver Dis, 16, 39
Gomez-Dominguez, 2006, A pilot study of atorvastatin treatment in dyslipdemidic, non-alcoholic fatty liver patients, Aliment Pharmacol Ther, 23, 1643, 10.1111/j.1365-2036.2006.02926.x
Rallidis, 2004, Pravastatin in patients with nonalcoholic steatohepatitis: results of a pilot study. Letter to the Editor, Artherosclerosis, 174, 193, 10.1016/j.atherosclerosis.2004.01.008
Brunt, 1999, Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions, Am J Gastroenterol, 94, 2467, 10.1111/j.1572-0241.1999.01377.x
Sridevi, 2007, Simvastatin (40 mg/d), adiponectin levels, and insulin sensitivity in subjects with metabolic syndrome, Am J Cardiol, 100, 1397, 10.1016/j.amjcard.2007.06.028
Leclercq, 2000, CYP2E1 and CYP4A as microsomal catalyst of lipid peroxides in murine nonalcoholic steatohepatitis, J Clin Invest, 105, 1067, 10.1172/JCI8814
Kern, 1995, The expression of tumor necrosis factor in human adipose tissue. Regulation of obesity, weight loss, and relationship to lipoprotein lipase, J Clin Invest, 95, 2111, 10.1172/JCI117899
Klover, 2003, Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice, Diabetes, 52, 2784, 10.2337/diabetes.52.11.2784
Tsochatzis, 2006, The evolving role of leptin and adiponectin in chronic liver diseases, Am J Gastroenterol, 101, 2629, 10.1111/j.1572-0241.2006.00848.x
Anania, 2007, Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease, Gastroenterol, 132, 2191, 10.1053/j.gastro.2007.03.055
Chitturi, 2002, Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity?, Hepatology, 36, 403, 10.1053/jhep.2002.34738
Nakao, 2002, Association between nonalcoholic fatty liver, markers of obesity, and serum leptin levels in young adults, Am J Gastroenterol, 97, 1796, 10.1111/j.1572-0241.2002.05846.x
Hui, 2004, Beyond insulin resistance in NASH: TNF-alpha or adiponectin?, Hepatology, 40, 46, 10.1002/hep.20280
Targher, 2006, Associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease, Clin Endocrinology, 64, 679, 10.1111/j.1365-2265.2006.02527.x
Shepherd, 1995, For the West of Scotland Coronary Prevention Study Group: prevention of coronary heart disease with pravastatin in men with hypercholesterolemia, N Engl J Med, 333, 1301, 10.1056/NEJM199511163332001
Devaraj, 2006, Direct demonstration of an anti-inflammatory effect of simvastatin in subjects with the metabolic syndrome, J Clin Endocrinol Metab, 91, 4489, 10.1210/jc.2006-0299
Zhao, 2005, Atorvastatin reduces serum leptin concentration in hypercholesterolemic rabbits, Clin Chim Acta, 360, 133, 10.1016/j.cccn.2005.04.021
Blanco-Colio, 2008, Adiponectin plasma levels are increased by atorvastatin treatment in subjects at high cardiovascular risk, Eur J Pharmacol, 586, 259, 10.1016/j.ejphar.2008.02.042
Chu, 2008, Atorvastatin does not affect insulin sensitivity and the adiponectin or leptin levels in hyperlipidemic Type 2 diabetes, J Endocrinol Invest, 31, 42, 10.1007/BF03345565