A Phase II Study of Sorafenib in Malignant Mesothelioma: Results of Cancer and Leukemia Group B 30307

Journal of Thoracic Oncology - Tập 5 Số 10 - Trang 1655-1661 - 2010
Sarita Dubey1, Pasi A. Jänne2, Lee M. Krug3, Herbert Pang4, Xiaofei Wang4, Robin Heinze4, Colleen Watt5, Jeff Crawford6, Robert A. Kratzke7, Everett E. Vokes8, Hedy L. Kindler8
1University of California,#R#San Francisco, California
2Dana Farber Cancer Institute, Boston, Massachusetts
3Memorial Sloan Kettering Cancer Center, New York, New York
4Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, North Carolina
5Cancer and Leukemia Group B Central Office, Chicago, Illinois
6Duke Medical Center, Durham, North Carolina
7Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota
8Department of Medicine, University of Chicago Medical Center, Chicago, Illinois

Tóm tắt

Từ khóa


Tài liệu tham khảo

Vogelzang, 2003, Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma, J Clin Oncol, 21, 2636, 10.1200/JCO.2003.11.136

Dvorak, 2002, Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy, J Clin Oncol, 20, 4368, 10.1200/JCO.2002.10.088

Strizzi, 2001, Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma, J Pathol, 193, 468, 10.1002/path.824

Ohta, 1999, VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours, Br J Cancer, 81, 54, 10.1038/sj.bjc.6690650

Takahashi, 1999, VEGF activates protein kinase C-dependent, but ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells, Oncogene, 18, 2221, 10.1038/sj.onc.1202527

Versnel, 1991, Human malignant mesothelioma cell lines express PDGF beta-receptors whereas cultured normal mesothelial cells express predominantly PDGF alpha-receptors, Oncogene, 6, 2005

Whitson, 2006, Molecular pathways in malignant pleural mesothelioma, Cancer Lett, 239, 183, 10.1016/j.canlet.2005.08.010

Klominek, 1998, Platelet-derived growth factor (PDGF) BB acts as a chemoattractant for human malignant mesothelioma cells via PDGF receptor beta-integrin alpha3beta1 interaction, Clin Exp Metastasis, 16, 529, 10.1023/A:1006542301794

Wilhelm, 2004, BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis, Cancer Res, 64, 7099, 10.1158/0008-5472.CAN-04-1443

Escudier, 2007, Sorafenib in advanced clear-cell renal-cell carcinoma, N Engl J Med, 356, 125, 10.1056/NEJMoa060655

Llovet, 2008, Sorafenib in advanced hepatocellular carcinoma, N Engl J Med, 359, 378, 10.1056/NEJMoa0708857

Byrne, 2004, Modified RECIST criteria for assessment of response in malignant pleural mesothelioma, Ann Oncol, 15, 257, 10.1093/annonc/mdh059

Steele, 2000, Phase II study of vinorelbine in patients with malignant pleural mesothelioma, J Clin Oncol, 18, 3912, 10.1200/JCO.2000.18.23.3912

Kindler, 2001, Gemcitabine for malignant mesothelioma: a phase II trial by the Cancer and Leukemia Group B, Lung Cancer, 31, 311, 10.1016/S0169-5002(00)00166-5

Stebbing, 2009, The efficacy and safety of weekly vinorelbine in relapsed malignant pleural mesothelioma, Lung Cancer, 63, 94, 10.1016/j.lungcan.2008.04.001

van Meerbeeck, 2005, J Clin Oncol, 23, 6881, 10.1200/JCO.20005.14.589

Abou-Alfa, 2006, Phase II study of sorafenib in patients with advanced hepatocellular carcinoma, J Clin Oncol, 24, 4293, 10.1200/JCO.2005.01.3441

Hayat, 2007, Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program, Oncologist, 12, 20, 10.1634/theoncologist.12-1-20

Karrison, 2007, Final analysis of a multi-center, double-blind, placebo-controlled, randomized phase II trial of gemcitabine/cisplatin (GC) plus bevacizumab (B) or placebo (P) in patients (pts) with malignant mesothelioma (MM), J Clin Oncol, 18s

Francart, 2009, A prognostic index for progression-free survival in malignant mesothelioma with application to the design of phase II trials: a combined analysis of 10 EORTC trials, Eur J Cancer, 45, 2304, 10.1016/j.ejca.2009.04.028

Krug, 2006, Potential role of histone deacetylase inhibitors in mesothelioma: clinical experience with suberoylanilide hydroxamic acid, Clin Lung Cancer, 7, 257, 10.3816/CLC.2006.n.003

Tsao, 2009, Malignant pleural mesothelioma, J Clin Oncol, 27, 2081, 10.1200/JCO.2008.19.8523

Tsao, 2007, Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion, Mol Cancer Ther, 6, 1962, 10.1158/1535-7163.MCT-07-0052

Jahan, 2005, Vatalanib in patients with previously untreated advanced malignant mesothelioma: preliminary analysis of a phase II study by the Cancer and Leukemia Group B (CALGB 30107), Lung Cancer, 49

Baas, 2005, Thalidomide in patients with malignant pleural mesothelioma, Lung Cancer, 48, 291, 10.1016/j.lungcan.2004.10.005

Kindler, 2001, SU5416 in malignant mesothelioma: a University of Chicago phase II consortium study, Proc Am Soc Clin Oncol, 20

Pavlakis, 2003, Thalidomide alone or in combination with cisplatin/gemcitabine in malignant pleural mesothelioma: interim results from two parallel non randomized phase II studies, Lung cancer, 41, S11, 10.1016/S0169-5002(03)91684-9

Nowak, 2008, Phase II study of sunitinib as second-line therapy in malignant pleural mesothelioma (MM), J Clin Oncol, 26, 10.1200/jco.2008.26.15_suppl.8063

Garland, 2009, A phase II study of novel oral antiangiogenic agent AZD2171 (NSC-732208) in malignant pleural mesothelioma, J Clin Oncol, 27