A Paradoxical Role for Myeloid-Derived Suppressor Cells in Sepsis and Trauma

Molecular Medicine - Tập 17 Số 3-4 - Trang 281-292 - 2011
Alex G. Cuenca1, Matthew J. Delano1, Kindra M. Kelly-Scumpia1, Cláudia Roberta de Castro Moreno1, Philip O. Scumpia1, Drake LaFace2, Paul G. Heyworth2, Philip A. Efron1, Lyle L. Moldawer1
1Department of Surgery, University of Florida College of Medicine, Room 6116, Shands Hospital, 1600 SW Archer Rd, Gainesville, Florida, 32610-0286, USA
2Merck Research Laboratories (formerly DNAX Research Institute), Palo Alto, California, USA

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Bronte V. (2009) Myeloid-derived suppressor cells in inflammation: uncovering cell subsets with enhanced immunosuppressive functions. Eur. J. Immunol. 39:2670–2.

Gabrilovich DI, Nagaraj S. (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9:162–74.

Ostrand-Rosenberg S, Sinha P. (2009) Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol. 182:4499–506.

Murphey ED, et al. (2004) Diminished bacterial clearance is associated with decreased IL-12 and interferon-gamma production but a sustained proinflammatory response in a murine model of postseptic immunosuppression. Shock. 21:415–25.

Young MR, Newby M, Wepsic HT. (1987) Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors. Cancer Res. 47:100–5.

Peranzoni E, et al. (2010) Myeloid-derived suppressor cell heterogeneity and subset definition. Curr. Opin. Immunol. 22:238–44.

Nagaraj S, et al. (2009) Regulatory myeloid suppressor cells in health and disease. Cancer Res. 69:7503–6.

Kusmartsev S, Gabrilovich DI. (2005) STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J. Immunol. 174:4880–91.

Gallina G, et al. (2006) Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J. Clin. Invest. 116:2777–90.

Angulo I, et al. (2000) Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosup-pressed mice. Blood. 95:212–20.

Rossner S, et al. (2005) Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro. Eur. J. Immunol. 35:3533–44.

Delano MJ, et al. (2007) MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J. Exp. Med. 204:1463–74.

Movahedi K, et al. (2008) Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood. 111:4233–44.

Youn JI, Nagaraj S, Collazo M, Gabrilovich DI. (2008) Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J. Immunol. 181:5791–802.

Zea AH, et al. (2005) Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res. 65:3044–8.

Filipazzi P, et al. (2007) Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine. J. Clin. Oncol. 25:2546–53.

Ochoa AC, Zea AH, Hernandez C, Rodriguez PC. (2007) Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. Clin. Cancer Res. 13:721s–6s.

Rodriguez PC, et al. (2009) Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res. 69:1553–60.

Nagaraj S, Gabrilovich DI. (2007) Myeloid-derived suppressor cells. Adv. Exp. Med. Biol. 601:213–23.

Corzo CA, et al. (2009) Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J. Immunol. 182(9):5693–701.

Kusmartsev S, Nefedova Y, Yoder D, Gabrilovich DI. (2004) Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. J. Immunol. 172:989–99.

Popovic PJ, Zeh HJ 3rd, Ochoa JB. (2007) Arginine and immunity. J.Nutr. 137:1681S–6S.

Marigo I, Dolcetti L, Serafini P, Zanovello P, Bronte V. (2008) Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol. Rev. 222:162–79.

Bronte V, Zanovello P. (2005) Regulation of immune responses by L-arginine metabolism. Nat. Rev. Immunol. 5:641–54.

Nagaraj S, et al. (2007) Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat. Med. 13(7):828–35.

Bunt SK, Sinha P, Clements VK, Leips J, Ostrand Rosenberg S. (2006) Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression. J. Immunol. 176(1):284–90.

Pande K, et al. (2009) Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactions. Mol. Ther. 17:508–15.

Sander LE, et al. (2010) Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J. Exp. Med. 207:1453–64.

Noel G, et al. (2007) Postburn monocytes are the major producers of TNF-alpha in the heterogeneous splenic macrophage population. Shock. 27:312–9.

Noel G, et al. (2010) A ribonucleotide reductase inhibitor reverses burn induced inflammatory defects. Shock. 34:535–44.

Noel JG, et al. (2005) Effect of thermal injury on splenic myelopoiesis. Shock. 23:115–22.

Noel JG, et al. (2007) Thermal injury elevates the inflammatory monocyte subpopulation in multiple compartments. Shock. 28:684–93.

Eruslanov E, Daurkin I, Ortiz J, Vieweg J, Kusmartsev S. (2010) Pivotal advance: tumormediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells. J. Leukoc. Biol. 88:839–48.

Vuk-Pavlovic S, et al. (2010) Immunosuppressive CD14+HLA-DRlow/-monocytes in prostate cancer. Prostate. 70:443–55.

Cheng P, et al. (2008) Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J. Exp. Med. 205:2235–49.

Ueda Y, Cain DW, Kuraoka M, Kondo M, Kelsoe G. (2009) IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia. J. Immunol. 182:6477–84.

Ueda Y, Kondo M, Kelsoe G. (2005) Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. J. Exp. Med. 201(11):1771–80.

Fearon DT, Locksley RM. (1996) The instructive role of innate immunity in the acquired immune response. Science. 272:50–3.

Scumpia PO, et al. (2010) Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling. J. Immunol. 184:2247–51.

Kusmartsev S, et al. (2003) All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. Cancer Res. 63:4441–9.

Kusmartsev S, et al. (2008) Reversal of myeloid cell-mediated immunosuppression in patients with metastatic renal cell carcinoma. Clin. Cancer Res. 14:8270–8.

Greifenberg V, Ribechini E, Rossner S, Lutz MB. (2009) Myeloid-derived suppressor cell activation by combined LPS and IFN-gamma treatment impairs DC development. Eur. J. Immunol. 39:2865–76.

Fricke I, et al. (2007) Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses. Clin Cancer Res. 13:4840–8.

Gabrilovich D, et al. (1998) Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood. 92:4150–66.

Khan SY, et al. (2006) Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood. 108:2455–62.

Ozao-Choy J, et al. (2009) The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res. 69:2514–22.

Laudanski K, De A, Miller-Graziano C. (2007) Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells. Eur. J. Immunol. 37:2812–24.

Makarenkova VP, Bansal V, Matta BM, Perez LA, Ochoa JB. (2006) CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J. Immunol. 176:2085–94.

Scumpia PO, et al. (2007) Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood. 110:3673–81.

Scumpia PO, et al. (2005) CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J. Immunol. 175:3282–6.

Opal SM, et al. (1999) Additive effects of human recombinant interleukin-11 and granulocyte colony-stimulating factor in experimental gramnegative sepsis. Blood. 93:3467–72.

Hotchkiss RS, et al. (1999) Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit. Care Med. 27:1230–51.

Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL. (1999) Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc. Nat. Acad. Sci. U. S. A. 96:9792–6.

Joyce-Shaikh B, et al. (2010) Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. J. Exp. Med. 207:579–89.

Pan PY, et al. (2008) Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood. 111:219–28.

Zhu B, et al. (2007) CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J. Immunol. 179:5228–37.

Gabrilovich DI, Velders MP, Sotomayor EM, Kast WM. (2001) Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells. J. Immunol. 166:5398–406.

Sinha P, Clements VK, Ostrand-Rosenberg S. (2005) Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease. J. Immunol. 174:636–45.

Dolcetti L, et al. (2010) Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF. Eur. J. Immunol. 40:22–35.

Huang B, et al. (2006) Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res. 66:1123–31.

Umemura N, et al. (2008) Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1-and M2-type characteristics. Journal of leukocyte biology. 83:1136–44.

Pan PY, et al. (2010) Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer. Cancer Res. 70(1):99–108.

Zhou Z, et al. (2010) Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells. Stem Cells. 28:620–32.