A Node-Expressed Transporter OsCCX2 Is Involved in Grain Cadmium Accumulation of Rice

Buha, 2017, Cadmium exposure as a putative risk factor for the development of pancreatic cancer: three different lines of evidence., Biomed. Res. Int., 8, 10.1155/2017/1981837

Cai, 2004, The cation/Ca(2+) exchanger superfamily: phylogenetic analysis and structural implications., Mol. Biol. Evol., 21, 1692, 10.1093/molbev/msh177

Clemens, 2013, Plant science: the key to preventing slow cadmium poisoning., Trends Plant Sci., 18, 92, 10.1016/j.tplants.2012.08.003

Emery, 2012, Protein phylogenetic analysis of Ca2+/cation antiporters and insights into their evolution in plants., Front. Plant Sci., 3, 10.3389/fpls.2012.00001

Feki-Tounsi, 2014, Cadmium as a possible cause of bladder cancer: a review of accumulated evidence., Environ. Sci. Pollut. Res., 21, 10561, 10.1007/s11356-014-2970-0

Garg, 2012, Microarray analysis reveals overlapping and specific transcriptional responses to different plant hormones in rice., Plant Signal. Behav., 7, 951, 10.4161/psb.20910

Goyer, 2004, Cadmium and cancer of prostate and testis., Biometals, 17, 555, 10.1023/b:biom.0000045738.59708.20

Guthrie, 2002, Guide to yeast genetics and molecular and cell biology., Methods Enzymol., 350, 18

Haruta, 2018, Environmental and genetic factors regulating localization of the plant plasma membrane H+-ATPase., Plant Physiol., 176, 364, 10.1104/pp.17.01126

Horiguchi, 1994, Hypoproduction of erythropoietin contributes to anemia in chronic cadmium intoxication: clinical study on Itai-itai disease in Japan., Arch. Toxicol., 68, 632, 10.1007/bf03208342

Huff, 2007, Hyperthermic effects of gold nanorods on tumor cells., Nanomedicine, 2, 125, 10.2217/17435889.2.1.125

Il’yasova, 2005, Cadmium and renal cancer., Toxicol. Appl. Pharmacol., 207, 179, 10.1016/j.taap.2004.12.005

Ishimaru, , OsNRAMP5, a major player for constitutive iron and manganese uptake in rice., Plant Signal. Behav., 7, 763, 10.4161/psb.20510

Ishimaru, , Characterizing the role of rice NRAMP5 in manganese, iron and cadmium transport., Sci. Rep., 2, 10.1038/srep00286

Jefferson, 1987, GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants., EMBO J., 6, 3901, 10.1002/j.1460-2075.1987.tb02730.x

Jin, 2003, Cadmium is a mutagen that acts by inhibiting mismatch repair., Nat. Genet., 34, 326, 10.1038/ng1172

Kobayashi, 2014, Iron deficiency responses in rice roots., Rice, 7, 10.1186/s12284-014-0027-0

Kuramata, 2009, Novel cysteine-rich peptides from Digitaria ciliaris and Oryza sativa enhance tolerance to cadmium by limiting its cellular accumulation., Plant Cell Physiol., 50, 106, 10.1093/pcp/pcn175

Lancilli, 2014, Cadmium exposure and sulfate limitation reveal differences in the transcriptional control of three sulfate transporter (Sultr1;2) genes in Brassica juncea., BMC Plant Biol., 14, 10.1186/1471-2229-14-132

Lee, 2009, Over-expression of OsIRT1 leads to increased iron and zinc accumulations in rice., Plant Cell Environ., 32, 408, 10.1111/j.1365-3040.2009.01935.x

Li, 2015, An endoplasmic reticulum magnesium transporter is essential for pollen development in Arabidopsis., Plant Sci., 231, 212, 10.1016/j.plantsci.2014.12.008

Li, 2016, CCX1, a putative Cation/Ca2+ exchanger, participates in regulation of reactive oxygen species homeostasis and leaf senescence., Plant Cell Physiol., 57, 2611, 10.1093/pcp/pcw175

Li, 1996, The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump., J. Biol. Chem., 271, 6509, 10.1074/jbc.271.11.6509

Lutzen, 2004, Cadmium inhibits human DNA mismatch repair in vivo., Biochem. Biophys. Res. Commun., 321, 21, 10.1016/j.bbrc.2004.06.102

Matovic, 2011, Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium., Arh. Hig. Rada Toksikol., 62, 65, 10.2478/10004-1254-62-2011-2075

Matovic, 2015, Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys., Food Chem. Toxicol., 78, 130, 10.1016/jict.2015.02.011

Matsuda, 2009, A novel plant cysteine-rich peptide family conferring cadmium tolerance to yeast and plants., Plant Signal. Behav., 4, 419, 10.4161/psb.4.5.8272

Miao, 2013, Targeted mutagenesis in rice using CRISPR-Cas system., Cell Res., 23, 1233, 10.1038/cr.2013.123

Misra, 2003, Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+., Cell. Signal., 15, 1059, 10.1016/s0898-6568(03)00117-7

Miyadate, 2011, OsHMA3, a P-1B-type of ATPase affects root-to-shoot cadmium translocation in rice by mediating efflux into vacuoles., New Phytol., 189, 190, 10.1111/j.1469-8137.2010.03459.x

Moon, 2013, Rice GLYCOSYLTRANSFERASE1 encodes a glycosyltransferase essential for pollen wall formation., Plant Physiol., 161, 663, 10.1104/pp.112.210948

Morris, 2008, AtCCX3 is an Arabidopsis endomembrane H+-dependent K+ transporter., Plant Physiol., 148, 1474, 10.1104/pp.108.118810

Nakanishi, 2006, Iron deficiency enhances cadmium uptake and translocation mediated by the Fe2+ transporters OsIRT1 and OsIRT2 in rice., Soil Sci. Plant Nutr., 52, 464, 10.1111/j.1747-0765.2006.00055.x

Rapisarda, 2018, Cadmium exposure and prostate cancer: insights, mechanisms and perspectives., Front. Biosci. (Landmark Ed.), 23, 1687, 10.2741/4667

Rodda, 2011, The timing of grain Cd accumulation in rice plants: the relative importance of remobilisation within the plant and root Cd uptake post-flowering., Plant Soil, 347, 105, 10.1007/s11104-011-0829-4

Sasaki, 2014, Overexpression of OsHMA3 enhances Cd tolerance and expression of Zn transporter genes in rice., J. Exp. Bot., 65, 6013, 10.1093/jxb/eru340

Sasaki, 2015, A node-localized transporter OsZIP3 is responsible for the preferential distribution of Zn to developing tissues in rice., Plant J., 84, 374, 10.1111/tpj.13005

Sasaki, 2012, Nramp5 is a major transporter responsible for manganese and cadmium uptake in rice., Plant Cell, 24, 2155, 10.1105/tpc.112.096925

Satoh-Nagasawa, 2012, Mutations in Rice (Oryza sativa) heavy metal ATPase 2 (OsHMA2) restrict the translocation of zinc and cadmium., Plant Cell Physiol., 53, 213, 10.1093/pcp/pcr166

Simon, 2016, PIN6 auxin transporter at endoplasmic reticulum and plasma membrane mediates auxin homeostasis and organogenesis in Arabidopsis., New Phytol., 211, 65, 10.1111/nph.14019

Singh, 2014, Genome-wide expressional and functional analysis of calcium transport elements during abiotic stress and development in rice., FEBS J., 281, 894, 10.1111/febs.12656

Song, 2015, Association between cadmium exposure and renal cancer risk: a meta-analysis of observational studies., Sci. Rep., 5, 10.1038/srep17976

Su, 2014, Effects of iron deficiency on subcellular distribution and chemical forms of cadmium in peanut roots in relation to its translocation., Environ. Exp. Bot., 97, 40, 10.1016/j.envexpbot.2013.10.001

Takahashi, , The role of heavy-metal ATPases, HMAs, in zinc and cadmium transport in rice., Plant Signal. Behav., 7, 1605, 10.4161/psb.22454

Takahashi, , The OsHMA2 transporter is involved in root-to-shoot translocation of Zn and Cd in rice., Plant Cell Environ., 35, 1948, 10.1111/j.1365-3040.2012.02527.x

Takahashi, , Role of the iron transporter OsNRAMP1 in cadmium uptake and accumulation in rice., Plant Signal. Behav., 6, 1813, 10.4161/psb.6.11.17587

Takahashi, , The OsNRAMP1 iron transporter is involved in Cd accumulation in rice., J. Exp. Bot., 62, 4843, 10.1093/jxb/err136

Takahashi, 2014, From laboratory to field: OsNRAMP5-knockdown rice is a promising candidate for Cd phytoremediation in paddy fields., PLoS One, 9, 10.1371/journal.pone.0098816

Tang, 2017, Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield., Sci. Rep., 7, 10.1038/s41598-017-14832-9

Tezuka, 2010, A single recessive gene controls cadmium translocation in the cadmium hyperaccumulating rice cultivar Cho-Ko-Koku., Theor. Appl. Genet., 120, 1175, 10.1007/s00122-009-1244-6

Toki, 2006, Early infection of scutellum tissue with Agrobacterium allows high-speed transformation of rice., Plant J., 47, 969, 10.1111/j.1365-313X.2006.02836.x

Ueno, 2011, Physiological, genetic, and molecular characterization of a high-Cd-accumulating rice cultivar, Jarjan., J. Exp. Bot., 62, 2265, 10.1093/jxb/erq383

Ueno, 2010, Gene limiting cadmium accumulation in rice., Proc. Natl. Acad. Sci. U.S.A., 107, 16500, 10.1073/pnas.1005396107

Uraguchi, 2011, Low-affinity cation transporter (OsLCT1) regulates cadmium transport into rice grains., Proc. Natl. Acad. Sci. U.S.A., 108, 20959, 10.1073/pnas.1116531109

Uraguchi, 2017, Identification of C-terminal regions in Arabidopsis thaliana phytochelatin synthase 1 specifically involved in activation by arsenite., Plant Cell Physiol., 59, 500, 10.1093/pcp/pcx204

Van Maele-Fabry, 2016, Dietary exposure to cadmium and risk of breast cancer in postmenopausal women: a systematic review and meta-analysis., Environ. Int., 86, 1, 10.1016/j.envint.2015.10.003

Vinceti, 2007, Case-control study of toenail cadmium and prostate cancer risk in Italy., Sci. Total Environ., 373, 77, 10.1016/j.scitotenv.2006.11.005

von Zglinicki, 1992, Very low cadmium concentrations stimulate DNA synthesis and cell growth., J. Cell Sci., 103, 1073, 10.1242/jcs.103.4.1073

Waisberg, 2003, Molecular and cellular mechanisms of cadmium carcinogenesis., Toxicology, 192, 95, 10.1016/s0300-483x(03)00305-6

Wang, 2008, Subcellular distribution and chemical forms of cadmium in Bechmeria nivea (L.) Gaud., Environ. Exp. Bot., 62, 389, 10.1016/j.envexpbot.2007.10.014

Watanabe, 2004, Food safety and epidemiology: new database of functional food factors., Biofactors, 22, 213, 10.1002/biof.5520220144

Weigel, 1980, Subcellular distribution and chemical form of cadmium in bean plants., Plant Physiol., 65, 480, 10.1104/pp.65.3.480

Wu, 2015, Genome-wide association mapping of cadmium accumulation in different organs of barley., New Phytol., 208, 817, 10.1111/nph.13512

Xu, 2017, Cadmium adsorption, chelation and compartmentalization limit root-to-shoot translocation of cadmium in rice (Oryza sativa L.)., Environ. Sci. Pollut. Res., 24, 11319, 10.1007/s11356-017-8775-1

Yadav, 2015, A rice tonoplastic calcium exchanger, OsCCX2 mediates Ca2+/cation transport in yeast., Sci. Rep., 5, 10.1038/srep17117

Yamaji, 2014, The node, a hub for mineral nutrient distribution in graminaceous plants., Trends Plant Sci., 19, 556, 10.1016/j.tplants.2014.05.007

Yamaji, 2017, Node-controlled allocation of mineral elements in Poaceae., Curr. Opin. Plant Biol., 39, 18, 10.1016/j.pbi.2017.05.002

Yamaji, 2017, Reducing phosphorus accumulation in rice grains with an impaired transporter in the node., Nature, 541, 10.1038/nature21404

Yamaji, 2013, Preferential delivery of zinc to developing tissues in rice is mediated by P-type heavy metal ATPase OsHMA2., Plant Physiol., 162, 927, 10.1104/pp.113.216564

Yan, 2016, A loss-of-function allele of OsHMA3 associated with high cadmium accumulation in shoots and grain of Japonica rice cultivars., Plant Cell Environ., 39, 1941, 10.1111/pce.12747

Yang, 2016, A small GTPase, OsRab6a, is involved in the regulation of iron homeostasis in rice., Plant Cell Physiol., 57, 1271, 10.1093/pcp/pcw073

Yang, 2014, OsNRAMP5 contributes to manganese translocation and distribution in rice shoots., J. Exp. Bot., 65, 4849, 10.1093/jxb/eru259

Yang, 2016, Excessive nitrate enhances cadmium (Cd) uptake by up-regulating the expression of OsIRT1 in rice (Oryza sativa)., Environ. Exp. Bot., 122, 141, 10.1016/j.envexpbot.2015.10.001

Yokosho, 2016, OsFRDL1 expressed in nodes is required for distribution of iron to grains in rice., J. Exp. Bot., 67, 5485, 10.1093/jxb/erw314

Yuan, 2012, Molecular characterization of a rice metal tolerance protein, OsMTP1., Plant Cell Rep., 31, 67, 10.1007/s00299-011-1140-9

Zhang, 2011, Characterization of an AtCCX5 gene from Arabidopsis thaliana that involves in high-affinity K+ uptake and Na+ transport in yeast., Biochem. Biophys. Res. Commun., 414, 96, 10.1016/j.bbrc.2011.09.030