A New Chemical Trick to Prevent House from Collapsing by Bacterial Pathogens

Chemical Research in Chinese Universities - 2022
Jiazhang Qiu1, Zhao-Qing Luo2
1State Key Laboratory for Zoonotic Diseases, College of Veterinary Medicine, Jilin University, Changchun, P. R. China
2Purdue Institute for Inflammation, Immunology and Infectious Disease and Department of Biological Sciences, Purdue University, West Lafayette, USA

Tóm tắt

Metazoans often induce cell death as an ultimate strategy to prevent disastrous damage to the body under circumstances when insults, such as infection are impossible to clear. Inflammatory cell death or pyroptosis not only eliminates the replicative niche for the pathogen but also stimulates effective immune protection. A recent study by Shao, Liu and colleagues found that the Shigella flexneri effector OspC3 inactivates an inflammasome by a novel posttranslational modification termed ADP-riboxanation. This finding has greatly expanded the chemical tool box of pathogens in their manipulation of host function, which may be used to probe unrecognized signaling mechanisms.

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Chemical Research in Chinese Universities

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