A NEWAPPROACH TODECODINGLIFE: Systems Biology

Annual Review of Genomics and Human Genetics - Tập 2 Số 1 - Trang 343-372 - 2001
Trey Ideker1,2,3,4,5, Timothy Galitski1,2,3,4,6, Leroy Hood1,2,3,4,6
1Departments of Bioengineering4, University of Washington, Seattle, Washington 98195;
2Departments of Computer Science and Engineering5, University of Washington, Seattle, Washington 98195;
3Departments of Immunology3, University of Washington, Seattle, Washington 98195;
4Departments of Molecular Biotechnology2, University of Washington, Seattle, Washington 98195;
5Institute for Systems Biology, Seattle, Washington 98105, USA. [email protected]
6Institute for Systems Biology1, Seattle, Washington 98105;

Tóm tắt

▪ Abstract  Systems biology studies biological systems by systematically perturbing them (biologically, genetically, or chemically); monitoring the gene, protein, and informational pathway responses; integrating these data; and ultimately, formulating mathematical models that describe the structure of the system and its response to individual perturbations. The emergence of systems biology is described, as are several examples of specific systems approaches.

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Annual Review of Genomics and Human Genetics

Tập 2 Số 1

343-372

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