A Molecular Switch for the Orientation of Epithelial Cell Polarization

Akhtar, 2013, An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium, Nat. Cell Biol., 15, 17, 10.1038/ncb2646 Apodaca, 2012, Role of membrane traffic in the generation of epithelial cell asymmetry, Nat. Cell Biol., 14, 1235, 10.1038/ncb2635 Bigorgne, 2014, TTC7A mutations disrupt intestinal epithelial apicobasal polarity, J. Clin. Invest., 124, 328, 10.1172/JCI71471 Boratkó, 2012, Cell cycle dependent association of EBP50 with protein phosphatase 2A in endothelial cells, PLoS ONE, 7, e35595, 10.1371/journal.pone.0035595 Bryant, 2008, From cells to organs: building polarized tissue, Nat. Rev. Mol. Cell Biol., 9, 887, 10.1038/nrm2523 Bryant, 2010, A molecular network for de novo generation of the apical surface and lumen, Nat. Cell Biol., 12, 1035, 10.1038/ncb2106 Cameron, 2009, PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity, Nat. Struct. Mol. Biol., 16, 624, 10.1038/nsmb.1606 Chen, 2012, Phosphorylation of EBP50 negatively regulates β-PIX-dependent Rac1 activity in anoikis, Cell Death Differ., 19, 1027, 10.1038/cdd.2012.4 Datta, 2011, Molecular regulation of lumen morphogenesis, Curr. Biol., 21, R126, 10.1016/j.cub.2010.12.003 deLeon, 2012, Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways, PLoS ONE, 7, e41039, 10.1371/journal.pone.0041039 Doyonnas, 2001, Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin, J. Exp. Med., 194, 13, 10.1084/jem.194.1.13 Fehon, 2010, Organizing the cell cortex: the role of ERM proteins, Nat. Rev. Mol. Cell Biol., 11, 276, 10.1038/nrm2866 Ferrari, 2008, ROCK-mediated contractility, tight junctions and channels contribute to the conversion of a preapical patch into apical surface during isochoric lumen initiation, J. Cell Sci., 121, 3649, 10.1242/jcs.018648 Fievet, 2004, Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin, J. Cell Biol., 164, 653, 10.1083/jcb.200307032 Fukasawa, 2011, Phosphorylation of podocalyxin (Ser415) Prevents RhoA and ezrin activation and disrupts its interaction with the actin cytoskeleton, Am. J. Pathol., 179, 2254, 10.1016/j.ajpath.2011.07.046 Gálvez-Santisteban, 2012, Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells, Nat. Cell Biol., 14, 838, 10.1038/ncb2541 Garbett, 2010, The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner, J. Cell Biol., 191, 397, 10.1083/jcb.201004115 Georgescu, 2014, NHERF1/EBP50 Controls Morphogenesis of 3D Colonic Glands by Stabilizing PTEN and Ezrin-Radixin-Moesin Proteins at the Apical Membrane, Neoplasia, 16, 365, 10.1016/j.neo.2014.04.004 Ichimura, 2013, Podocalyxin regulates pronephric glomerular development in zebrafish, Physiological reports, 1, 10.1002/phy2.74 Jou, 1998, Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity, J. Cell Biol., 142, 85, 10.1083/jcb.142.1.85 Lämmermann, 2008, Rapid leukocyte migration by integrin-independent flowing and squeezing, Nature, 453, 51, 10.1038/nature06887 Li, 2002, PDZ domain-mediated interaction of rabbit podocalyxin and Na(+)/H(+) exchange regulatory factor-2, Am. J. Physiol. Renal Physiol., 282, F1129, 10.1152/ajprenal.00131.2001 Murakoshi, 2011, Local, persistent activation of Rho GTPases during plasticity of single dendritic spines, Nature, 472, 100, 10.1038/nature09823 O’Brien, 2001, Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly, Nat. Cell Biol., 3, 831, 10.1038/ncb0901-831 Paszek, 2005, Tensional homeostasis and the malignant phenotype, Cancer Cell, 8, 241, 10.1016/j.ccr.2005.08.010 Renkawitz, 2009, Adaptive force transmission in amoeboid cell migration, Nat. Cell Biol., 11, 1438, 10.1038/ncb1992 Roland, 2011, Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization, Proc. Natl. Acad. Sci. USA, 108, 2789, 10.1073/pnas.1010754108 Rosse, 2010, PKC and the control of localized signal dynamics, Nat. Rev. Mol. Cell Biol., 11, 103, 10.1038/nrm2847 Sanz-Moreno, 2010, The plasticity of cytoskeletal dynamics underlying neoplastic cell migration, Curr. Opin. Cell Biol., 22, 690, 10.1016/j.ceb.2010.08.020 Schmieder, 2004, Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and Ezrin in MDCK cells, J. Am. Soc. Nephrol., 15, 2289, 10.1097/01.ASN.0000135968.49899.E8 Strilić, 2009, The molecular basis of vascular lumen formation in the developing mouse aorta, Dev. Cell, 17, 505, 10.1016/j.devcel.2009.08.011 Strilić, 2010, Electrostatic cell-surface repulsion initiates lumen formation in developing blood vessels, Curr. Biol., 20, 2003, 10.1016/j.cub.2010.09.061 Takeda, 2000, Expression of podocalyxin inhibits cell-cell adhesion and modifies junctional properties in Madin-Darby canine kidney cells, Mol. Biol. Cell, 11, 3219, 10.1091/mbc.11.9.3219 Takeda, 2001, Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton, J. Clin. Invest., 108, 289, 10.1172/JCI12539 Tomar, 2009, A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells, J. Cell Sci., 122, 1852, 10.1242/jcs.046870 Tozluoğlu, 2013, Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions, Nat. Cell Biol., 15, 751, 10.1038/ncb2775 Wyckoff, 2006, ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo, Curr. Biol., 16, 1515, 10.1016/j.cub.2006.05.065 Yu, 2005, Beta1-integrin orients epithelial polarity via Rac1 and laminin, Mol. Biol. Cell, 16, 433, 10.1091/mbc.E04-05-0435 Yu, 2007, Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis, Mol. Biol. Cell, 18, 1693, 10.1091/mbc.E06-11-1052 Yu, 2008, Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity, EMBO Rep., 9, 923, 10.1038/embor.2008.135