A Modified Controlled Cortical Impact Technique to Model Mild Traumatic Brain Injury Mechanics in Mice

2003, Report to Congress on Mild Traumatic Brain Injury in the United States: Steps to Prevent a Serious Public Health Problem

Dikmen, 2001, Mild head injury: facts and artifacts, J Clin Exp Neuropsychol, 23, 729, 10.1076/jcen.23.6.729.1019

Signoretti, 2010, Biochemical and neurochemical sequelae following mild traumatic brain injury: summary of experimental data and clinical implications, Neurosurg Focus, 29, E1, 10.3171/2010.9.FOCUS10183

Hamilton, 2010, Mild traumatic brain injury in children, Semin Pediatr Surg, 19, 271, 10.1053/j.sempedsurg.2010.06.005

Teasdale, 1974, Assessment of coma and impaired consciousness: a practical scale, Lancet, 304, 81, 10.1016/S0140-6736(74)91639-0

Malec, 2007, The mayo classification system for traumatic brain injury severity, J Neurotrauma, 24, 1417, 10.1089/neu.2006.0245

Saatman, 2008, Classification of traumatic brain injury for targeted therapies, J Neurotrauma, 25, 719, 10.1089/neu.2008.0586

Lee, 2005, Neuroimaging in traumatic brain imaging, NeuroRx, 2, 372, 10.1602/neurorx.2.2.372

Le, 2009, Neuroimaging of traumatic brain injury, Mt Sinai J Med J Transl Pers Med, 76, 145, 10.1002/msj.20102

Bigler, 2012, Neuropathology of mild traumatic brain injury: relationship to neuroimaging findings, Brain Imaging Behav, 6, 108, 10.1007/s11682-011-9145-0

Powell, 2008, Accuracy of mild traumatic brain injury diagnosis, Arch Phys Med Rehabil, 89, 1550, 10.1016/j.apmr.2007.12.035

Ruff, 2009, Recommendations for diagnosing a mild traumatic brain injury: a national academy of neuropsychology education paper, Arch Clin Neuropsychol, 24, 3, 10.1093/arclin/acp006

McKinlay, 2010, Controversies and outcomes associated with mild traumatic brain injury in childhood and adolescences, Child Care Health Dev, 36, 3, 10.1111/j.1365-2214.2009.01006.x

Yeates, 2010, Mild traumatic brain injury and postconcussive symptoms in children and adolescents, J Int Neuropsychol Soc, 16, 953, 10.1017/S1355617710000986

Beauchamp, 2008, Pharmacology of traumatic brain injury: where is the “golden bullet”?, Mol Med, 14, 731, 10.2119/2008-00050.Beauchamp

Ward, 1975, The Development of a Detailed Finite Element Brain Model, 10.4271/751163

Willinger, 1999, Three-dimensional human head finite-element model validation against two experimental impacts, Ann Biomed Eng, 27, 403, 10.1114/1.165

Ruan, 1994, Dynamic response of the human head to impact by three-dimensional finite element analysis, J Biomech Eng, 116, 44, 10.1115/1.2895703

Levchakov, 2006, Computational studies of strain exposures in neonate and mature rat brains during closed head impact, J Neurotrauma, 23, 1570, 10.1089/neu.2006.23.1570

Viano, 2005, Concussion in professional football: brain responses by finite element analysis: part 9, Neurosurgery, 57, 891, 10.1227/01.NEU.0000186950.54075.3B

Viano, 2005, Concussion in professional football: biomechanics of the striking player – part 8, Neurosurgery, 56, 266, 10.1227/01.NEU.0000150035.54230.3C

Viano, 2007, Concussion in professional football, Neurosurgery, 61, 313, 10.1227/01.NEU.0000279969.02685.D0

Meaney, 1990, Physical Model Studies of Cortical Brain Deformation in Response to High Strain Rate Inertial Loading, 215

Margulies, 1990, Physical model simulations of brain injury in the primate, J Biomech, 23, 823, 10.1016/0021-9290(90)90029-3

Margulies, 1992, A proposed tolerance criterion for diffuse axonal injury in man, J Biomech, 25, 917, 10.1016/0021-9290(92)90231-O

Shreiber, 1997, In vivo Thresholds for Mechanical Injury to the Blood-Brain Barrier, 10.4271/973335

Bain, 1999, Thresholds for Mechanical Injury to the in vivo White Matter, 10.4271/99SC19

Bain, 2000, Tissue-level thresholds for axonal damage in an experimental model of central nervous system white matter injury, J Biomech Eng, 122, 615, 10.1115/1.1324667

Morrison, 2000, Dynamic mechanical stretch of organotypic brain slice cultures induces differential genomic expression: relationship to mechanical parameters, J Biomech Eng, 122, 224, 10.1115/1.429650

Morrison, 2003, A tissue level tolerance criterion for living brain developed with an in vitro model of traumatic mechanical loading, Stapp Car Crash J, 47, 93

Morrison, 2006, An in vitro model of traumatic brain injury utilising two-dimensional stretch of organotypic hippocampal slice cultures, J Neurosci Methods, 150, 192, 10.1016/j.jneumeth.2005.06.014

Singh, 2006, A new model of traumatic axonal injury to determine the effects of strain and displacement rates, Stapp Car Crash J, 50, 601

Elkin, 2007, Region-specific tolerance criteria for the living brain, Stapp Car Crash J, 51, 127

Bayly, 2006, In vivo imaging of rapid deformation and strain in an animal model of traumatic brain injury, J Biomech, 39, 1086, 10.1016/j.jbiomech.2005.02.014

Pfister, 2003, An in vitro uniaxial stretch model for axonal injury, Ann Biomed Eng, 31, 589, 10.1114/1.1566445

Rashid, 2012, Mechanical characterization of brain tissue in tension at dynamic strain rates, J Mech Behav Biomed Mater, 33, 43, 10.1016/j.jmbbm.2012.07.015

Zhang, 2004, A proposed injury threshold for mild traumatic brain injury, J Biomech Eng, 126, 226, 10.1115/1.1691446

Ruan, 1993, Finite Element Modeling of Direct Head Impact, 10.4271/933114

McAllister, 2012, Maximum principal strain and strain rate associated with concussion diagnosis correlates with changes in corpus callosum white matter indices, Ann Biomed Eng, 40, 127, 10.1007/s10439-011-0402-6

Kleiven, 2007, Predictors for traumatic brain injuries evaluated through accident reconstructions, Stapp Car Crash J, 51, 81

Kimpara, 2012, Mild traumatic brain injury predictors based on angular accelerations during impacts, Ann Biomed Eng, 40, 114, 10.1007/s10439-011-0414-2

Dokko, 2003, Validation of the human head FE model against pedestrian accident and its tentative application to the examination of the existing tolerance curve, 19

Meaney, 1995, Biomechanical analysis of experimental diffuse axonal injury, J Neurotrauma, 12, 689, 10.1089/neu.1995.12.689

Shreiber, 1999, Experimental investigation of cerebral contusion: histopathological and immunohistochemical evaluation of dynamic cortical deformation, J Neuropathol Exp Neurol, 58, 153, 10.1097/00005072-199902000-00005

Thibault, 1992, Biomechanical aspects of a fluid percussion model of brain injury, J Neurotrauma, 9, 311, 10.1089/neu.1992.9.311

Feeney, 1981, Responses to cortical injury: I. Methodology and local effects of contusions in the rat, Brain Res, 211, 67, 10.1016/0006-8993(81)90067-6

Shohami, 1988, Experimental closed head injury in rats: prostaglandin production in a noninjured zone, Neurosurgery, 22, 859, 10.1227/00006123-198805000-00009

Chen, 1996, An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits, J Neurotrauma, 13, 557, 10.1089/neu.1996.13.557

Marmarou, 1994, A new model of diffuse brain injury in rats. Part I: pathophysiology and biomechanics, J Neurosurg, 80, 291, 10.3171/jns.1994.80.2.0291

Longhi, 2005, Temporal window of vulnerability to repetitive experimental concussive brain injury, Neurosurgery, 56, 364, 10.1227/01.NEU.0000149008.73513.44

Ellingson, 2005, New mechanism for inducing closed head injury in the rat, Biomed Sci Instrum, 41, 86

Fijalkowski, 2007, New rat model for diffuse brain injury using coronal plane angular acceleration, J Neurotrauma, 24, 1387, 10.1089/neu.2007.0268

Kilbourne, 2009, Novel model of frontal impact closed head injury in the rat, J Neurotrauma, 26, 2233, 10.1089/neu.2009.0968

Creed, 2011, Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function, J Neurotrauma, 28, 547, 10.1089/neu.2010.1729

Albert-Weissenberger, 2012, An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice, Exp Transl Stroke Med, 4, 1, 10.1186/2040-7378-4-1

Fijalkowski, 2009, A finite element model of region-specific response for mild diffuse brain injury, Stapp Car Crash J, 53, 193

Blumbergs, 1994, Staining of amyloid percursor protein to study axonal damage in mild head injury, Lancet, 344, 1055, 10.1016/S0140-6736(94)91712-4

Blumbergs, 1995, Topography of axonal injury as defined by amyloid precursor protein and the sector scoring method in mild and severe closed head injury, J Neurotrauma, 12, 565, 10.1089/neu.1995.12.565

Cloots, 2013, Multi-scale mechanics of traumatic brain injury: predicting axonal strains from head loads, Biomech Model Mechanobiol, 12, 137, 10.1007/s10237-012-0387-6

Ho, 2007, Dynamic response of the brain with vasculature: a three-dimensional computational study, J Biomech, 40, 3006, 10.1016/j.jbiomech.2007.02.011

Kleiven, 2002, Correlation of an FE model of the human head with local brain motion–consequences for injury prediction, Stapp Car Crash J, 46, 123

Zhang, 2001, Recent advances in brain injury research: a new human head model development and validation, Stapp Car Crash J, 45, 369

Zhang, 2002, Computational study of the contribution of the vasculature on the dynamic response of the brain, Stapp Car Crash J, 46, 145

Zhang, 2003, A new biomechanical predictor for mild traumatic brain injury–A preliminary finding, 137

Yoganandan, 2008, Influence of angular acceleration–deceleration pulse shapes on regional brain strains, J Biomech, 41, 2253, 10.1016/j.jbiomech.2008.04.019

Miller, 1998, Finite Element Modeling Approaches for Predicting Injury in an Experimental Model of Severe Diffuse Axonal Injury, 10.4271/983154

Mao, 2010, Finite element analysis of controlled cortical impact-induced cell loss, J Neurotrauma, 27, 877, 10.1089/neu.2008.0616

Mao, 2006, Application of a finite element model of the brain to study traumatic brain injury mechanisms in the rat, Stapp Car Crash J, 50, 583

Meaney, 1994, Modification of the cortical impact model to produce axonal injury in the rat cerebral cortex, J Neurotrauma, 11, 599, 10.1089/neu.1994.11.599

Peña, 2005, Brain tissue biomechanics in cortical contusion injury: a finite element analysis, Acta Neurochir Suppl, 95, 333, 10.1007/3-211-32318-X_68

Mao, 2010, Computational neurotrauma – design, simulation, and analysis of controlled cortical impact model, Biomech Model Mechanobiol, 9, 763, 10.1007/s10237-010-0212-z

Smith, 1995, A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects, J Neurotrauma, 12, 169, 10.1089/neu.1995.12.169

Pleasant, 2011, Rate of neurodegeneration in the mouse controlled cortical impact model is influenced by impactor tip shape: implications for mechanistic and therapeutic studies, J Neurotrauma, 28, 2245, 10.1089/neu.2010.1499

Lusardi, 2004, A device to study the initiation and propagation of calcium transients in cultured neurons after mechanical stretch, Ann Biomed Eng, 32, 1546, 10.1114/B:ABME.0000049038.75368.75

Cernak, 2005, Animal models of head trauma, NeuroRx, 2, 410, 10.1602/neurorx.2.3.410

Oliveira, 2011, Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments, Learn Mem, 18, 161, 10.1101/lm.1939811

Oliveira, 2010, Post-training reversible inactivation of the hippocampus enhances novel object recognition memory, Learn Mem, 17, 155, 10.1101/lm.1625310

Anderson, 2003, Fluoro-Jade B stains quiescent and reactive astrocytes in the rodent spinal cord, J Neurotrauma, 20, 1223, 10.1089/089771503770802899

Dixon, 1988, Physiologic, histopathologic, and cineradiographic characterization of a new fluid-percussion model of experimental brain injury in the rat, J Neurotrauma, 5, 91, 10.1089/neu.1988.5.91

Thompson, 2005, Lateral fluid percussion brain injury: a 15-year review and evaluation, J Neurotrauma, 22, 42, 10.1089/neu.2005.22.42

Dixon, 1987, A fluid percussion model of experimental brain injury in the rat, J Neurosurg, 67, 110, 10.3171/jns.1987.67.1.0110

McIntosh, 1987, Traumatic brain injury in the rat: characterization of a midline fluid-percussion model, Cent Nerv Syst Trauma, 4, 119, 10.1089/cns.1987.4.119

Farkas, 2006, Mechanoporation induced by diffuse traumatic brain injury: an irreversible or reversible response to injury?, J Neurosci, 26, 3130, 10.1523/JNEUROSCI.5119-05.2006

Goforth, 1999, Enhancement of AMPA-mediated current after traumatic injury in cortical neurons, J Neurosci, 19, 7367, 10.1523/JNEUROSCI.19-17-07367.1999

Patel, 2014, Single-neuron NMDA receptor phenotype influences neuronal rewiring and reintegration following traumatic injury, J Neurosci, 34, 4200, 10.1523/JNEUROSCI.4172-13.2014

Singh, 2012, N-methyl-d-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit, J Biol Chem, 287, 4348, 10.1074/jbc.M111.253740

Laurer, 2001, Mild head injury increasing the brain’s vulnerability to a second concussive impact, J Neurosurg, 95, 859, 10.3171/jns.2001.95.5.0859

Bennett, 2012, Diffusion tensor imaging detects axonal injury in a mouse model of repetitive closed-skull traumatic brain injury, Neurosci Lett, 513, 160, 10.1016/j.neulet.2012.02.024

Shitaka, 2011, Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity, J Neuropathol Exp Neurol, 70, 551, 10.1097/NEN.0b013e31821f891f

Shultz, 2011, A single mild fluid percussion injury induces short-term behavioral and neuropathological changes in the Long-Evans rat: support for an animal model of concussion, Behav Brain Res, 224, 326, 10.1016/j.bbr.2011.06.012