A Meta-Analysis of Observational Studies of the Association Between Chronic Occupational Exposure to Lead and Amyotrophic Lateral Sclerosis

Byrne, 2011, Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis., J Neurol Neurosurg Psychiatry, 82, 623, 10.1136/jnnp.2010.224501

Sato, 2014, Seven amyotrophic lateral sclerosis patients diagnosed only after development of respiratory failure., J Clin Neurosci, 21, 1341, 10.1016/j.jocn.2013.11.021

Wijesekera, 2009, Amyotrophic lateral sclerosis., Orphanet J Rare Dis, 4, 3, 10.1186/1750-1172-4-3

Chio, 2012, Extensive genetics of ALS: a population-based study in Italy., Neurology, 79, 1983, 10.1212/WNL.0b013e3182735d36

Chen, 2013, Genetics of amyotrophic lateral sclerosis: an update., Molecular Neurodegeneration, 8, 28, 10.1186/1750-1326-8-28

Al-Chalabi, 2012, The genetics and neuropathology of amyotrophic lateral sclerosis., Acta Neuropathol, 124, 339, 10.1007/s00401-012-1022-4

Abel, 2012, ALSoD: a user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics., Hum Mutat, 33, 1345, 10.1002/humu.22157

Pfister, 2013, Familial amyotrophic lateral sclerosis in Alberta, Canada., Amyotroph Lateral Scler Frontotemporal Degener, 14, 273, 10.3109/21678421.2012.754044

Robberecht, 2000, Genetics of amyotrophic lateral sclerosis., J Neurol, 247, VI2

van Blitterswijk, 2012, How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia: can we learn from other noncoding repeat expansion disorders Curr Opin Neurol., , 25, 689

Smith, 2013, The C9ORF72 expansion mutation is a common cause of ALS-FTD in Europe and has a single founder., Eur J Hum Genet, 21, 102, 10.1038/ejhg.2012.98

Ratti, 2012, C9ORF72 repeat expansion in a large Italian ALS cohort: evidence of a founder effect., Neurobiol Aging, 33, 2528.e7, 10.1016/j.neurobiolaging.2012.06.008

Soong, 2014, Extensive molecular genetic survey of Taiwanese patients with amyotrophic lateral sclerosis., Neurobiol Aging, 35, 2423.e1, 10.1016/j.neurobiolaging.2014.05.008

Vinceti, 2012, Environmental risk factors for amyotrophic lateral sclerosis: methodological issues in epidemiologic studies., Ann Ig, 24, 407

Al-Chalabi, 2010, An estimate of amyotrophic lateral sclerosis heritability using twin data., J Neurol Neurosurg Psychiatry, PMC2988617, 1324, 10.1136/jnnp.2010.207464

Wingo, 2011, The heritability of amyotrophic lateral sclerosis in a clinically ascertained united states research registry., PLoS One, 6, e27985, 10.1371/journal.pone.0027985

Meireles, 2009, Genetic studies of amyotrophic lateral sclerosis: controversies and perspectives., Amyotrophic Lat Scler, 10, 1, 10.1080/17482960802585469

Johnson, 2009, The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis., Neurotoxicology, 30, 761, 10.1016/j.neuro.2009.07.010

Sutedja, 2009, Exposure to chemicals and metals and risk of amyotrophic lateral sclerosis: a systematic review., Amyotroph Lateral Scler, 10, 302, 10.3109/17482960802455416

Sutedja, 2009, What we truly know about occupation as a risk factor for ALS: a critical and systematic review., Amyotroph Lateral Scler, 10, 295, 10.3109/17482960802430799

Ahmed, 2011, Amyotrophic lateral sclerosis: what role does environment play Neurol Clin., , 29, 689

Migliore, 2009, Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases., Mutat Res, 667, 82, 10.1016/j.mrfmmm.2008.10.011

Oh, 2007, A case of amyotrophic lateral sclerosis in electronic parts manufacturing worker exposed to lead., Neurotoxicology, 28, 324, 10.1016/j.neuro.2006.12.004

Livesley, 1968, Chronic lead intoxication mimicking motor neurone disease., Br Med J, 4, 387, 10.1136/bmj.4.5627.387-d

Campbell, 1970, Motor neurone disease and exposure to lead., J Neurol Neurosurg Psychiatry, 33, 877, 10.1136/jnnp.33.6.877

Chancellor, 1993, Risk factors for motor neuron disease: a case-control study based on patients from the Scottish motor neuron disease register., J Neurol Neurosurg Psychiatry, 56, 1200, 10.1136/jnnp.56.11.1200

Deapen, 1986, A case-control study of amyotrophic lateral sclerosis., Am J Epidemiol, 123, 790, 10.1093/oxfordjournals.aje.a114308

Gresham, 1986, Amyotrophic lateral sclerosis and occupational heavy metal exposure: a case-control study., Neuroepidemiology, 5, 29, 10.1159/000110810

Gresham, 1987, Amyotrophic lateral sclerosis and history of skeletal fracture: a case-control study., Neurology, 37, 717, 10.1212/WNL.37.4.717

Gresham, 1992, Lead exposure and ALS., Neurology, 42, 2228, 10.1212/WNL.42.11.2228-a

Kamel, 2002, Lead exposure and amyotrophic lateral sclerosis., Epidemiology, 13, 311, 10.1097/00001648-200205000-00012

Kamel, 2005, Lead exposure as a risk factor for amyotrophic lateral sclerosis., Neurodegener Dis, 2, 195, 10.1159/000089625

McGuire, 1997, Occupational exposures and amyotrophic lateral sclerosis. A population-based case-control study., Am J Epidemiol, 145, 1076, 10.1093/oxfordjournals.aje.a009070

Pierce-Ruhland, 1981, Repeat study of antecedent events in motor neuron disease., Ann Clin Res, 13, 102

Binazzi, 2009, An exploratory case-control study on spinal and bulbar forms of amyotrophic lateral sclerosis in the province of Rome., Amyotroph Lateral Scler, 10, 361, 10.3109/17482960802382313

Gunnarsson, 1992, A case-control study of motor neurone disease: Its relation to heritability, and occupational exposures, particularly to solvents., Br J Ind Med, 49, 791

Malek, 2014, Environmental and occupational risk factors for amyotrophic lateral sclerosis: a case-control study., Neurodegener Dis, 14, 31, 10.1159/000355344

Morahan, 2006, Amyotrophic lateral sclerosis and exposure to environmental toxins: An Australian case-control study., Neuroepidemiology, 27, 130, 10.1159/000095552

Provinciali, 1990, Antecedent events in amyotrophic lateral sclerosis: Do they influence clinical onset and progression Neuroepidemiology., , 9, 255

Qureshi, 2006, Analysis of factors that modify susceptibility and rate of progression in amyotrophic lateral sclerosis (ALS)., Amyotroph Lateral Scler, 7, 173, 10.1080/14660820600640596

Park, 2005, Potential occupational risks for neurodegenerative diseases., Am J Ind Med, 48, 63, 10.1002/ajim.20178

Fang, 2009, Workplace exposures and the risk of amyotrophic lateral sclerosis., Environ Health Perspect, 117, 1387, 10.1289/ehp.0900580

Fang, 2010, Association between blood lead and the risk of amyotrophic lateral sclerosis., Am J Epidemiol, 171, 1126, 10.1093/aje/kwq063

Scarpa, 1988, Epidemiology of amyotrophic lateral sclerosis in the province of Modena, Italy. influence of environmental exposure to lead., Acta Neurol Scand, 77, 456, 10.1111/j.1600-0404.1988.tb05940.x

Turabelidze, 2008, An epidemiologic investigation of amyotrophic lateral sclerosis in Jefferson county, Missouri, 1998-2002., Neurotoxicology, 29, 81, 10.1016/j.neuro.2007.09.003

Turner, 2011, Residential pesticides and childhood leukemia: a systematic review and meta-analysis., Cien Saude Colet, 16, 1915, 10.1590/S1413-81232011000300026

Stroup, 2000, Meta-analysis of observational studies in epidemiology: a proposal for reporting. meta-analysis of observational studies in epidemiology (MOOSE) group., JAMA, 283, 2008, 10.1001/jama.283.15.2008

Downs, 1998, The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions., J Epidemiol Community Health, 52, 377, 10.1136/jech.52.6.377

Lu, 2014, Diabetes and risk of Parkinsons disease: an updated meta-analysis of case-control studies., PLoS One, 9, e85781, 10.1371/journal.pone.0085781

Breslow, 1980, Satatistical methods in cancer research., IARC Sci Publ, 32, 5

Wartenberg, 2001, Residential EMF exposure and childhood leukemia: meta-analysis and population attributable risk., Bioelectromagnetics, 5, S86, 10.1002/1521-186X(2001)22:5+<::AID-BEM1026>3.0.CO;2-3

Liberati, 2009, The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration., J Clin Epidemiol, 62, e1, 10.1016/j.jclinepi.2009.06.006

Yu, 2014, Environmental risk factors and amyotrophic lateral sclerosis (ALS): a case-control study of ALS in Michigan., PLoS One, 9, e101186, 10.1371/journal.pone.0101186

Thomson, 2006, Neuropathies associated with excessive exposure to lead., Muscle Nerve, 33, 732, 10.1002/mus.20510

Bachmeyer, 2012, Lead poisoning mimicking amyotrophic lateral sclerosis: an adverse effect of rituals., Am J Med, 125, e5, 10.1016/j.amjmed.2011.11.030

Fluri, 2007, Lead poisoning from the beauty case: neurologic manifestations in an elderly woman., Neurology, 69, 929, 10.1212/01.wnl.0000267846.97398.e2

Boothby, 1974, Reversible forms of motor neuron disease lead neuritis., Arch Neurol, 31, 18, 10.1001/archneur.1974.00490370044005

Felmus, 1976, Antecedent events in amyotrophic lateral sclerosis., Neurology, 26, 167, 10.1212/WNL.26.2.167

Mandybur, 1979, Increased spinal cord lead content in amyotrophic lateral sclerosispossibly a secondary phenomenon., Med Hypotheses, 5, 1313, 10.1016/0306-9877(79)90099-9

Petkau, 1974, Lead content of neuromuscular tissue in amyotrophic lateral sclerosis: Case report and other considerations., Br J Ind Med, 31, 275

Conradi, 1976, Abnormal tissue distribution of lead in amyotrophic lateral sclerosis., J Neurol Sci, 29, 259, 10.1016/0022-510X(76)90175-1

Conradi, 1978, Increased plasma levels of lead in patients with amyotrophic lateral sclerosis compared with control subjects as determined by flameless atomic absorption spectrophotometry., J Neurol Neurosurg Psychiatry, 41, 389, 10.1136/jnnp.41.5.389

Kurlander, 1979, Metals in spinal cord tissue of patients dying of motor neuron disease., Ann Neurol, 6, 21, 10.1002/ana.410060105

Roos, 2013, Metal concentrations in cerebrospinal fluid and blood plasma from patients with amyotrophic lateral sclerosis., Biol Trace Elem Res, 151, 159, 10.1007/s12011-012-9547-x

Conradi, 1978, Lead concentration in skeletal muscle in amyotrophic lateral sclerosis patients and control subjects., J Neurol Neurosurg Psychiatry, 41, 1001, 10.1136/jnnp.41.11.1001

Vinceti, 1997, Lead, cadmium, and selenium in the blood of patients with sporadic amyotrophic lateral sclerosis., Ital J Neurol Sci, 18, 87, 10.1007/BF01999568

Kapaki, 1989, Determination of cerebrospinal fluid and serum lead levels in patients with amyotrophic lateral sclerosis and other neurological diseases., Experientia, 45, 1108, 10.1007/BF01950171

Cavalleri, 1984, Lead in cerebrospinal fluid and its relationship to plasma lead in humans., J Appl Toxicol, 4, 63, 10.1002/jat.2550040202

Stober, 1983, Lead concentrations in blood, plasma, erythrocytes, and cerebrospinal fluid in amyotrophic lateral sclerosis., J Neurol Sci, 61, 21, 10.1016/0022-510X(83)90051-5

Conradi, 1980, Abnormal distribution of lead in amyotrophic lateral sclerosis-reestimation of lead in the cerebrospinal fluid., J Neurol Sci, 48, 413, 10.1016/0022-510X(80)90112-4

Damstra, 1977, Toxicological properties of lead., Environ Health Perspect, 19, 297, 10.1289/ehp.7719297

Mazliah, 1989, The effects of long-term lead intoxication on the nervous system of the chicken., Neurosci Lett, 101, 253, 10.1016/0304-3940(89)90541-7

Mulligan, 2013, Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis., Proteins, 81, 1285, 10.1002/prot.24285

Kim, 2011, Effects of lead exposure on nitric oxide-associated gene expression in the olfactory bulb of mice., Biol Trace Elem Res, 142, 683, 10.1007/s12011-010-8791-1

Baranowska-Bosiacka, 2012, Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead., Brain Res, 1435, 56, 10.1016/j.brainres.2011.11.062

Rotunno, 2013, An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis., Front Cell Neurosci, 7, 253, 10.3389/fncel.2013.00253

Goering, 1993, Lead-protein interactions as a basis for lead toxicity., Neurotoxicology, 14, 45

Grad, 2014, Prion-like activity of CuZn superoxide dismutase: Implications for amyotrophic lateral sclerosis., Prion, 8, 33, 10.4161/pri.27602

Grad, 2011, Intermolecular transmission of superoxide dismutase 1 misfolding in living cells., Proc Natl Acad Sci U S A, 108, 16398, 10.1073/pnas.1102645108