A LIFE COURSE APPROACH TO CHRONIC DISEASE EPIDEMIOLOGY

Annual Review of Public Health - Tập 26 Số 1 - Trang 1-35 - 2005
John Lynch1, George Davey Smith2
11Center for Social Epidemiology and Population Health, Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48104-2548;
22Department of Social Medicine, University of Bristol, BS8 2PR, Bristol, United Kingdom;

Tóm tắt

▪ Abstract  A life course approach to chronic disease epidemiology uses a multidisciplinary framework to understand the importance of time and timing in associations between exposures and outcomes at the individual and population levels. Such an approach to chronic diseases is enriched by specification of the particular way that time and timing in relation to physical growth, reproduction, infection, social mobility, and behavioral transitions, etc., influence various adult chronic diseases in different ways, and more ambitiously, by how these temporal processes are interconnected and manifested in population-level disease trends. In this review, we discuss some historical background to life course epidemiology and theoretical models of life course processes, and we review some of the empirical evidence linking life course processes to coronary heart disease, hemorrhagic stroke, type II diabetes, breast cancer, and chronic obstructive pulmonary disease. We also underscore that a life course approach offers a way to conceptualize how underlying socio-environmental determinants of health, experienced at different life course stages, can differentially influence the development of chronic diseases, as mediated through proximal specific biological processes.

Từ khóa


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Annual Review of Public Health

Tập 26 Số 1

1-35

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