A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila

Nature Neuroscience - Tập 4 Số 12 - Trang 1182-1186 - 2001
Anupama Dahanukar1, Kara Foster1, Wynand Marinus van der Goes van Naters1, John R. Carlson1
1Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, USA

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Nayak, S. & Singh, R. N. Sensilla on the tarsal segments and mouthparts of adult Drosophila melanogaster Meigen (Diptera: Drosophilidae). Int. J. Insect Morphol. & Embryol. 12, 273–291 (1983).

Stocker, R. The organization of the chemosensory system in Drosophila melanogaster: a review. Cell Tissue Res. 275, 3–26 (1994).

Singh, R. N. Neurobiology of the gustatory systems of Drosophila and some terrestrial insects. Microsc. Res. Tech. 39, 547–563 (1997).

Dethier, V. The Hungry Fly (Harvard Press, Cambridge, Massachusetts, 1976).

Stocker, R. F. & Schorderet, M. Cobalt filling of sensory projections from internal and external mouthparts in Drosophila. Cell Tissue Res. 216, 513–523 (1981).

Shanbag, S. R. & Singh, R. N. Functional implications of the projections of neurons from individual labellar sensillum of Drosophila melanogaster as revealed by neuronal marker horseradish peroxidase. Cell Tissue Res. 267, 273–282 (1992).

Chaudhari, N., Landin, A. & Roper, S. A metabotropic glutamate receptor variant functions as a taste receptor. Nature Neurosci. 3, 113–119 (2000).

Adler, E. et al. A novel family of mammalian taste receptors. Cell 100, 693–702 (2000).

Matsunami, H., Montmayeur, J. & Buck, L. A family of candidate taste receptors in human and mouse. Nature 404, 601–604 (2000).

Chandrashekar, J. et al. T2Rs function as bitter taste receptors. Cell 100, 703–711 (2000).

Nelson, G. et al. Mammalian sweet taste receptors. Cell 106, 381–390 (2001).

Montmayeur, J. P., Liberles, S. D., Matsunami, H. & Buck, L. B. A candidate taste receptor gene near a sweet taste locus. Nature Neurosci. 4, 492–498 (2001).

Max, M. et al. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nature Genetics 28, 58–63 (2001).

Sainz, E., Korley, J. N., Battey, J. F. & Sullivan, S. L. Identification of a novel member of the T1R family of putative taste receptors. J. Neurochemistry 77, 896–903 (2001).

Clyne, P., Warr, C. & Carlson, J. Candidate taste receptors in Drosophila. Science 287, 1830–1834 (2000).

Dambly-Chaudiere, C. et al. The paired box gene pox neuro: a determinant of poly-innervated sense organs in Drosophila. Cell 69, 159–172 (1992).

Scott, K. et al. A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell 104, 661–673 (2001).

Dunipace, L., Meister, S., McNealy, C. & Amrein, H. Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system. Curr. Biol. 11, 822–835 (2001).

Tanimura, T., Isono, K., Takamura, T. & Shimada, I. Genetic dimorphism in the taste sensitivity to trehalose in Drosophila melanogaster. J. Comp. Physiol. 147, 433–437 (1982).

Tanimura, T., Isono, K. & Yamamoto, M. Taste sensitivity to trehalose and its alteration by gene dosage in Drosophila melanogaster. Genetics 119, 399–406 (1988).

Ishimoto, H., Matsumoto, A. & Tanimura, T. Molecular identification of a taste receptor gene for trehalose in Drosophila. Science 289, 116–119 (2000).

Ray, K., Hartenstein, V. & Rodrigues, V. Development of the taste bristles on the labellum of Drosophila melanogaster. Dev. Biol. 155, 26–37 (1993).

Hodgson, E., Lettvin, J. & Roeder, K. Physiology of a primary chemoreceptor unit. Science 122, 417–418 (1955).

Rodrigues, V. & Siddiqi, O. A gustatory mutant of Drosophila defective in pyranose receptors. Mol. Gen. Genet. 181, 406–408 (1981).

Tanimura, T. & Shimada, I. Multiple receptor proteins for sweet taste in Drosophila discriminated by papain treatment. J. Comp. Physiol. 141, 265–269 (1981).

Wieczorek, H. & Wolff, G. The labellar sugar receptor of Drosophila. J. Comp. Physiol. A 164, 825–834 (1989).

Ueno, K. et al. Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a. Curr. Biol. 11, 1451–1455 (2001).

L'Etoile, N. & Bargmann, C. Olfaction and odor discrimination are mediated by the C. elegans guanylyl cyclase ODR-1. Neuron 25, 575–586 (2000).

Glendinning, J., Chaudhari, N. & Kinnamon, S. Transduction and molecular biology. in Neurobiology of Taste and Smell II (eds. Finger, T. & Restrepo, D.) 315–351 (Academic Press, New York, 2000).

Amakawa, T., Ozaki, M. & Kawata, K. Effects of cyclic GMP on the sugar taste receptor cell of the fly Phormia regina. J. Insect Physiol. 36, 281–286 (1990).

Murikami, M. & Kijima, H. Transduction ion channels directly gated by sugars on the insect taste cell. J. Gen. Physiol. 115, 455–466 (2000).