A Genome-Wide Overexpression Screen in Yeast for Small-Molecule Target Identification

Chemistry & Biology - Tập 12 - Trang 55-63 - 2005
Hendrik Luesch1, Tom Y.H. Wu1, Pingda Ren2, Nathanael S. Gray2, Peter G. Schultz1,2, Frantisek Supek2
1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037
2Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121

Tài liệu tham khảo

Bjornsti, 2002, Cancer therapeutics in yeast, Cancer Cell, 2, 267, 10.1016/S1535-6108(02)00160-5 Forsburg, 2001, The art and design of genetic screens: yeast, Nat. Rev. Genet., 2, 659, 10.1038/35088500 Foury, 1997, Human genetic diseases: a cross-talk between man and yeast, Gene, 195, 1, 10.1016/S0378-1119(97)00140-6 Hartwell, 1997, Integrating genetic approaches into the discovery of anticancer drugs, Science, 278, 1064, 10.1126/science.278.5340.1064 Hughes, 2002, Yeast and drug discovery, Funct. Integr. Genomics, 2, 199, 10.1007/s10142-002-0059-1 Parsons, 2003, Yeast genomics and proteomics in drug discovery and target validation, Prog. Cell Cycle Res., 5, 159 Winzeler, E.A., Shoemaker, D.D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J.D., Bussey, H., et al. (1999). Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285, 901–906. Giaever, 2002, Functional profiling of the Saccharomyces cerevisiae genome, Nature, 418, 387, 10.1038/nature00935 Giaever, 1999, Genomic profiling of drug sensitivities via induced haploinsufficiency, Nat. Genet., 21, 278, 10.1038/6791 Lum, 2004, Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes, Cell, 116, 121, 10.1016/S0092-8674(03)01035-3 Giaever, 2004, Chemogenomic profiling: identifying the functional interactions of small molecules in yeast, Proc. Natl. Acad. Sci. USA, 101, 793, 10.1073/pnas.0307490100 Hughes, 2000, Functional discovery via a compendium of expression profiles, Cell, 102, 109, 10.1016/S0092-8674(00)00015-5 Tong, 2001, Systematic genetic analysis with ordered arrays of yeast deletion mutants, Science, 294, 2364, 10.1126/science.1065810 Ooi, 2003, DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray, Nat. Genet., 35, 277, 10.1038/ng1258 Parsons, 2004, Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways, Nat. Biotechnol., 22, 62, 10.1038/nbt919 Rine, 1983, Targeted selection of recombinant clones through gene dosage effects, Proc. Natl. Acad. Sci. USA, 80, 6750, 10.1073/pnas.80.22.6750 Launhardt, 1998, Drug-induced phenotypes provide a tool for the functional analysis of yeast genes, Yeast, 14, 935, 10.1002/(SICI)1097-0061(199807)14:10<935::AID-YEA289>3.0.CO;2-9 Vahlensieck, 1994, Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A, Curr. Genet., 25, 95, 10.1007/BF00309532 Ding, 2002, A combinatorial scaffold approach toward kinase-directed heterocycle libraries, J. Am. Chem. Soc., 124, 1594, 10.1021/ja0170302 Sridhar, 2000, Protein kinases as therapeutic targets, Pharm. Res., 17, 1345, 10.1023/A:1007507224529 Garrett, 1999, CDK inhibition and cancer therapy, Curr. Opin. Genet. Dev., 9, 104, 10.1016/S0959-437X(99)80015-X Zimmermann, J. (1995). Preparation of 2-anilinopyrimidines as protein kinase C inhibitors. PCT Int. Appl. WO 9509851. Schindler, 2000, Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase, Science, 289, 1938, 10.1126/science.289.5486.1938 Ruetz, 2003, Chemical and biological profile of dual Cdk1 and Cdk2 inhibitors. Curr. Med. Chem, Anti-Canc. Agents, 3, 1, 10.2174/1568011033353605 Guthrie, 1991 Heinisch, 1999, The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae, Mol. Microbiol., 32, 671, 10.1046/j.1365-2958.1999.01375.x Measday, 1997, A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, Mol. Cell. Biol., 17, 1212, 10.1128/MCB.17.3.1212 Lenburg, 2001, Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase, Genetics, 157, 39, 10.1093/genetics/157.1.39 Espinoza, 1994, Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85, Science, 266, 1388, 10.1126/science.7973730 Measday, 1994, The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast, Science, 266, 1391, 10.1126/science.7973731 Roberts, 1994, Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth, Genes Dev., 8, 2974, 10.1101/gad.8.24.2974 Cook, 1997, Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway, Nature, 390, 85, 10.1038/36355 Madhani, 1999, Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants, Proc. Natl. Acad. Sci. USA, 96, 12530, 10.1073/pnas.96.22.12530 Cherkasova, 1999, Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p, Genetics, 151, 989, 10.1093/genetics/151.3.989 Marini, 1996, A pathway in the yeast cell division cycle linking protein kinase C (Pkc1) to activation of Cdc28 at START, EMBO J., 15, 3040, 10.1002/j.1460-2075.1996.tb00667.x Levin, 1992, Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect, J. Cell Biol., 116, 1221, 10.1083/jcb.116.5.1221 Madden, 1997, SBF cell cycle regulator as a target of the yeast PKC-MAP kinase pathway, Science, 275, 1781, 10.1126/science.275.5307.1781 Igual, 1996, Coordinated regulation of gene expression by the cell cycle transcription factor SWI4 and the protein kinase C MAP kinase pathway for yeast cell integrity, EMBO J., 15, 5001, 10.1002/j.1460-2075.1996.tb00880.x Gray, 1997, A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator, EMBO J., 16, 4924, 10.1093/emboj/16.16.4924 Baetz, 2001, Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4, Mol. Cell. Biol., 21, 6515, 10.1128/MCB.21.19.6515-6528.2001 Irie, 1993, MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C, Mol. Cell. Biol., 13, 3076, 10.1128/MCB.13.5.3076 Valdivia, 2003, The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane, Proc. Natl. Acad. Sci. USA, 100, 10287, 10.1073/pnas.1834246100 Knockaert, 2000, Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilized inhibitors, Chem. Biol., 7, 411, 10.1016/S1074-5521(00)00124-1 Wijnen, 2002, The G1 cyclin Cln3 promotes cell cycle entry via the transcription factor Swi6, Mol. Cell. Biol., 22, 4402, 10.1128/MCB.22.12.4402-4418.2002 White, 1998, Clinical, cellular, and molecular factors that contribute to antifungal drug resistance, Clin. Microbiol. Rev., 11, 382, 10.1128/CMR.11.2.382