A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

Bernardi, 1999, Mitochondrial transport of cations, Physiol. Rev., 79, 1127, 10.1152/physrev.1999.79.4.1127 Bernardi, 1981, Cytochrome c as an electron shuttle between the outer and inner mitochondrial membranes, J. Biol. Chem., 256, 7187, 10.1016/S0021-9258(19)68946-5 Bernardi, 1999, Mitochondria and cell death. Mechanistic aspects and methodological issues, Eur. J. Biochem., 264, 687, 10.1046/j.1432-1327.1999.00725.x Cheng, 2001, BCL-2, BCL-XL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis Mol, Cell, 8, 705 Clipstone, 1992, Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation, Nature, 357, 695, 10.1038/357695a0 Eskes, 1998, Bax-induced cytochrome c release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions, J. Cell Biol., 143, 217, 10.1083/jcb.143.1.217 Frank, 2001, The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis, Dev. Cell, 1, 515, 10.1016/S1534-5807(01)00055-7 Frey, 2000, The internal structure of mitochondria, Trends Biochem. Sci., 25, 319, 10.1016/S0968-0004(00)01609-1 Goldstein, 2000, The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant, Nat. Cell Biol., 2, 156, 10.1038/35004029 Green, 1998, Mitochondria and apoptosis, Science, 281, 1309, 10.1126/science.281.5381.1309 Hackenbrock, 1966, Ultrastructural bases for metabolically linked mechanical activity in mitochondria. I. Reversible ultrastructural changes with change in metabolic steady state in isolated liver mitochondria, J. Cell Biol., 30, 269, 10.1083/jcb.30.2.269 Hajek, 2001, Rate-limiting step preceding cytochrome c release in cells primed for Fas-mediated apoptosis revealed by analysis of cellular mosaicism of respiratory changes, J. Biol. Chem., 276, 606, 10.1074/jbc.M007871200 Hoppel, 1968, The action of digitonin on rat liver mitochondria. The effects on enzyme content, Biochem. J., 107, 367, 10.1042/bj1070367 Huser, 1998, Imaging the permeability pore transition in single mitochondria, Biophys. J., 74, 2129, 10.1016/S0006-3495(98)77920-2 Kluck, 1999, The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol, J. Cell Biol., 147, 809, 10.1083/jcb.147.4.809 Kroemer, 1998, The mitochondrial death/life regulator in apoptosis and necrosis, Annu. Rev. Physiol., 60, 619, 10.1146/annurev.physiol.60.1.619 Lehninger, 1951, Phosphorylation coupled to oxidation of dihydrodiphosphopyridine nucleotide, J. Biol. Chem., 190, 345, 10.1016/S0021-9258(18)56077-4 Lemasters, 1998, The mitochondrial permeability transition in cell death, Biochim. Biophys. Acta, 1366, 177, 10.1016/S0005-2728(98)00112-1 Li, 1997, Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade, Cell, 91, 479, 10.1016/S0092-8674(00)80434-1 Luo, 1998, Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors, Cell, 94, 481, 10.1016/S0092-8674(00)81589-5 Mancini, 1997, Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line, J. Cell Biol., 138, 449, 10.1083/jcb.138.2.449 Mannella, 2002, Topology of the mitochondrial inner membrane, IUBMB Life, 52, 1 Margolin, 2000, Organelle division, Curr. Biol., 10, R328, 10.1016/S0960-9822(00)00458-9 Marko, 1996, Sterecon—three-dimensional reconstructions from stereoscopic contouring, J. Struct. Biol., 116, 93, 10.1006/jsbi.1996.0016 Mootha, 2001, A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c, EMBO J., 20, 661, 10.1093/emboj/20.4.661 Nicholls, 1980, Pathways of cytochrome c oxidation by soluble and membrane-bound cytochrome aa3, Can. J. Biochem., 58, 969, 10.1139/o80-132 Nicolli, 1996, Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin A-sensitive channel, J. Biol. Chem., 271, 2185, 10.1074/jbc.271.4.2185 Penczek, 1995, Double-tilt electron tomography, Ultramicroscopy, 60, 393, 10.1016/0304-3991(95)00078-X Perotti, 1983, Quantitative cytochemistry of the diaminobenzidine cytochrome oxidase reaction product in mitochondria of cardiac muscle and pancreas, J. Histochem. Cytochem., 31, 351, 10.1177/31.3.6186730 Petronilli, 1989, The inner mitochondrial membrane contains ion-conducting channels similar to those found in bacteria, FEBS Lett., 259, 137, 10.1016/0014-5793(89)81513-3 Petronilli, 1999, Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes of mitochondrial calcein fluorescence, Biophys. J., 76, 725, 10.1016/S0006-3495(99)77239-5 Radermacher, 1992, Weighted back-projection methods Sanchez-Alcazar, 2001, Tumor necrosis factor-alpha increases the steady-state reduction of cytochrome b of the mitochondrial respiratory chain in metabolically inhibited L929 cells, J. Biol. Chem., 275, 13353, 10.1074/jbc.275.18.13353 Sheridan, 1981, Biophysical and morphological correlates of kinetic change and death in a starved human melanoma cell line, J. Cell Sci., 49, 119, 10.1242/jcs.49.1.119 Shimizu, 2000, Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity, Proc. Natl. Acad. Sci. USA, 97, 577, 10.1073/pnas.97.2.577 Single, 1998, Simultaneous release of adenylate kinase and cytochrome c in cell death, Cell Death Differ., 5, 1001, 10.1038/sj.cdd.4400462 von Ahsen, 2000, Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release, J. Cell Biol., 150, 1027, 10.1083/jcb.150.5.1027 Wei, 2000, tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c, Genes Dev., 14, 2060, 10.1101/gad.14.16.2060 Wei, 2001, Proapoptotic BAX and BAK, Science, 292, 727, 10.1126/science.1059108 Yin, 1999, Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis, Nature, 400, 886, 10.1038/23730 Zha, 2000, Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis, Science, 290, 1761, 10.1126/science.290.5497.1761 Zong, 2001, BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak, Genes Dev., 15, 1481, 10.1101/gad.897601 Zoratti, 1995, The mitochondrial permeability transition, Biochim. Biophys. Acta, 1241, 139, 10.1016/0304-4157(95)00003-A